Protein Alignment EIF2S1 and tif211

DIOPT Version :10

• Sequence 1: NP_004085.1
• Gene: EIF2S1 / 1965
• HGNCID: 3265
• Length: 315
• Species: Homo sapiens
• Sequence 2: NP_594081.1
• Gene: tif211 / 2543455
• PomBaseID: SPAC3G9.09C
• Length: 306
• Species: Schizosaccharomyces pombe
• Alignment Length: 315
• Identity: 166/315 - (52%)
• Similarity: 231/315 - (73%)
• Gaps: 20/315 - (6%)

Human     1 MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRI 65
            |...|||.|:::||||:::|:||||.|.||||||.||||:|||||:||||||||||||:.|.||:
pombe     1 MSTTSCRMYENRFPEVDELVVVNVRQIQEMGAYVKLLEYDNIEGMVLLSELSRRRIRSVQKHIRV 65

Human    66 GRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESL 130
            ||||.|||:|||||||||||||||||||:.:|||::|.|||.|:||:||:||    ..:..||::
pombe    66 GRNEVVVVLRVDKEKGYIDLSKRRVSPEDVVKCEERFNKSKAVHSIMRHIAE----KHNVPLETM 126

Human   131 FQRTAWVFDDKYKRPGYGAYDAFKHAVSDPS-ILDSLD------LNEDEREVLINNINRRLTPQA 188
            :....|..   |::.|: ||||||.|:|:|. :.:.|:      :|:     |:..|:||||||.
pombe   127 YTTIGWPL---YRKYGH-AYDAFKLAISNPDHVFEGLEPPKSGVIND-----LLAQISRRLTPQP 182

Human   189 VKIRADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQ 253
            :|||||:||.|:|||||:|:|.||:|..:..||.:|||:.|:|||.||:.|..|:::.||..|.:
pombe   183 IKIRADVEVTCFGYEGINAIKAALKAAEDVHTEEVPIKVKLVAPPLYVLLTNALDKSLGLKKLEE 247

Human   254 AMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEE 308
            |:..|::.|....|...|:|:||.|::|||.|||..|::.|:||||:.||::.::
pombe   248 AIGAIEKSITASNGTCTVKMKPKAVSETDELELADLMKKFEKENAEISGDEEDDQ 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF2S1	NP_004085.1	PTZ00248	4..315	CDD:240329	165/312 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..315		7/16 (44%)
tif211	NP_594081.1	PTZ00248	5..306	CDD:240329	165/311 (53%)