Protein Alignment EIF2S1 and eif-2alpha

DIOPT Version :10

• Sequence 1: NP_004085.1
• Gene: EIF2S1 / 1965
• HGNCID: 3265
• Length: 315
• Species: Homo sapiens
• Sequence 2: NP_001368001.1
• Gene: eif-2alpha / 171769
• WormBaseID: WBGene00021351
• Length: 342
• Species: Caenorhabditis elegans
• Alignment Length: 312
• Identity: 172/312 - (55%)
• Similarity: 229/312 - (73%)
• Gaps: 13/312 - (4%)

Human     4 LSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRN 68
            :.||||:::||:||:.|:.||:.||:|||||.|.|||:.||||||||||||||||:|||||:||:
 Worm     1 MKCRFYENQFPDVEETVVANVKMIADMGAYVRLSEYNDKEGMILLSELSRRRIRSVNKLIRVGRS 65

Human    69 ECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQR 133
            |.||||||||:|||||||||||..::..:|:::|..:|.|.||||||||.:.||.||:||.|:|:
 Worm    66 ESVVVIRVDKDKGYIDLSKRRVYQKDLKQCDERFANAKMVNSILRHVAEQVGYTTDEELEDLYQK 130

Human   134 TAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVA 198
            |||.||.|.||.. .:|||||.|:::|:|||..|::.|.:|.|:.:|.::||||||||||||||:
 Worm   131 TAWHFDRKEKRKA-ASYDAFKKAITEPTILDECDISADIKEKLLEDIRKKLTPQAVKIRADIEVS 194

Human   199 CYGYEGIDAVKEALRAGLNCSTENMPIKINLIAPPRYVMTTTTLERTEGLSVLSQAMAVIKEKIE 263
            |:.|:||||||.||.||.|||....||||||||.|.:|:||.||:|..|:..::..:..||..||
 Worm   195 CFDYDGIDAVKAALIAGKNCSNGTFPIKINLIAAPHFVVTTQTLDREGGIEAVNSILDTIKNAIE 259

Human   264 EKRGVFNVQMEPKVVTDTDETELARQMERLERENAEVDGDDDAEEMEAKAED 315
            ..:|.|.::.|.::|||.|:            |..:.|||:|.||.|...::
 Worm   260 GFKGKFTIKEEARIVTDIDD------------EKKKGDGDEDEEESEEDEDE 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EIF2S1	NP_004085.1	PTZ00248	4..315	CDD:240329	172/310 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..315		8/21 (38%)
eif-2alpha	NP_001368001.1	PTZ00248	3..276	CDD:240329	161/273 (59%)