DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Robo3 and robo2

DIOPT Version :9

Sequence 1:XP_006510170.1 Gene:Robo3 / 19649 MGIID:1343102 Length:1403 Species:Mus musculus
Sequence 2:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster


Alignment Length:1630 Identity:432/1630 - (26%)
Similarity:645/1630 - (39%) Gaps:425/1630 - (26%)


- Green bases have known domain annotations that are detailed below.


Mouse    21 RDISNSSELLFGFNSSLAALNPSLLPPGDPSLNG-SRVGP-EDAMPRIVEQPPDLVVSRGEPATL 83
            ||.......:...:.|..|:.|.||...  .||| ::||. :...|||:|.|.|..|.:.:|.|.
  Fly    48 RDFHGERLKIMPVDRSRRAVFPLLLLLA--GLNGLTQVGALKGENPRIIEHPMDTTVPKNDPFTF 110

Mouse    84 PCRAEGRPRPNIEWYKNGARVATAREDPRAHRLLLPSGALFFPRIVHGRRSRPDEGVYTCVARNY 148
            .|:|||.|.|.|:|:|:|..:.|   |..:||::||:|.|||.:::|.|| ..|.|.|.|.|:|.
  Fly   111 NCQAEGNPTPTIQWFKDGRELKT---DTGSHRIMLPAGGLFFLKVIHSRR-ESDAGTYWCEAKNE 171

Mouse   149 LGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVMECVPPKGHPEPLVTWKKGKIKLK---EE 210
            .|.|.||||:|:||.|||:||..|.|..||.||.|:|||..|:|.|||.::|:|....|.   .:
  Fly   172 FGVARSRNATLQVAFLRDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNK 236

Mouse   211 EGRITIRGGKLMMSHTFKSDAGMYMCVASNMAGERESGAAELVVLERPSFLRRPINQVVLADAPV 275
            ..|| :.||.|.:....:||.|.|.||..|:.|.|||..|.|.|..||..:|.|.||..:..:.|
  Fly   237 RIRI-VDGGNLAIQEARQSDDGRYQCVVKNVVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSSV 300

Mouse   276 NFLCEVQGDPQPNLHWRK--DDGELPAGRYEIRSDHSLWIDQVSSEDEGTYTCVAENSVGRAEAS 338
            .|.|.:.|||.|::.||:  ..|.:|..|..:..|.||.:|.|:.||.|.|||.|:|:||...|:
  Fly   301 VFQCRIGGDPLPDVLWRRTASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITAT 365

Mouse   339 GSLSVHVPPQFVTKPQNQTVAPGANVSFQCETKGNPPPAIFWQKEGSQVLLFPSQ-------SLQ 396
            |.|:||.||:||.:|:||.|..|..|.|:|:..|:|.|.::|..||:..||.|..       :|.
  Fly   366 GILTVHAPPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLT 430

Mouse   397 PMGRLLVSPRGQLNITEVKIGDGGYYV-CQAVSVAGSILAKALLEIKGASIDGLPPIILQGPANQ 460
            |.||.:      |:|......|.|..| |.|::..||:.::.::.: ....:..||||.|||.||
  Fly   431 PEGRSV------LSIARFAREDSGKVVTCNALNAVGSVSSRTVVSV-DTQFELPPPIIEQGPVNQ 488

Mouse   461 TLVLGSSVWLPCRVIGNPQPNIQWKKDERWLQG------DDSQFNLMDNGTLHIASIQ-EMDMGF 518
            ||.:.|.|.||||.:|.|.|.:.|     :|.|      :..:.||.|.|.|.|:.:| ..|.|.
  Fly   489 TLPVKSIVVLPCRTLGTPVPQVSW-----YLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGL 548

Mouse   519 YSCVAKSSIGEATWNSWLRKQEDWGASPGPATGPSNP-------------PGPPSQPIVTEVTAN 570
            |:|||.:..|:::|:.:||...           |:||             ||||.:|.:.|...|
  Fly   549 YTCVASNRNGKSSWSGYLRLDT-----------PTNPNIKFFRAPELSTYPGPPGKPQMVEKGEN 602

Mouse   571 SITLTW-KPNPQSGATATSYVIEAFSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGA 634
            |:||:| :.|...|::...||||.|.:...:.|..|...||..|:|.:||.|...|.||:||..:
  Fly   603 SVTLSWTRSNKVGGSSLVGYVIEMFGKNETDGWVAVGTRVQNTTFTQTGLLPGVNYFFLIRAENS 667

Mouse   635 WGLSEPSPVSEPVQ------------TQADSSLSRPAEDPWKGQRGLAEVAVRMQEPTVLGPRTL 687
            .|||.|||:|||:.            ::|.:||             |:...|.:...:|:...::
  Fly   668 HGLSLPSPMSEPITVGTRYFNSGLDLSEARASL-------------LSGDVVELSNASVVDSTSM 719

Mouse   688 QVSW-TVDGPVQLVQGFRVSWRIAGLDQGSWTMLDLQSP--HKQSTVLRGLPP------------ 737
            :::| .::|  :.|:||.|..|            .|.:|  :..:.|.....|            
  Fly   720 KLTWQIING--KYVEGFYVYAR------------QLPNPIVNNPAPVTSNTNPLLGSTSTSASAS 770

Mouse   738 ---GAQIQIKVQV---------QGQEGLGAESPFVTR---------------------------- 762
               .|.|..|..:         ..|.|.||.:|..|:                            
  Fly   771 ASASALISTKPNIAAAGKRDGETNQSGGGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYEF 835

Mouse   763 -SIP------------------EEAPSGPPQGVAVALGGDRNSSVTVSWEPPLPSQRNGVITEYQ 808
             .:|                  |:.||..|.|:...|  ..:|:|.:.|:.|....|:||:..|.
  Fly   836 FIVPFYKSVEGKPSNSRIARTLEDVPSEAPYGMEALL--LNSSAVFLKWKAPELKDRHGVLLNYH 898

Mouse   809 IWCLG-----NESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAATSAGVGVASAPVLVQLPFP 868
            :...|     |.||...|.:....:.::..:.|..|.:|...|||..:||||....|..::|. |
  Fly   899 VIVRGIDTAHNFSRILTNVTIDAASPTLVLANLTEGVMYTVGVAAGNNAGVGPYCVPATLRLD-P 962

Mouse   869 PAAEPGPEVSEGL---AERLAKVLRKPAFLAGSSAACGALLLGFCAALYRRQK----QRKELS-- 924
            ......|.:::..   .:.:..||.:|.|:....|....|:|.|.|.::.::|    ::..|:  
  Fly   963 ITKRLDPFINQRYPINQDHVNDVLTQPWFIILLGAILAVLMLSFGAMVFVKRKHMMMKQSALNTM 1027

Mouse   925 --HYTASFAYTPAVSFPHSEGLSGSSSRPPMGLGPAAYPWLADS-----WPHPPRSPSAQEPRGS 982
              ::|:.....|::|..:..|.                 ||..|     |...|...|.:..:..
  Fly  1028 RGNHTSDVLKMPSLSARNGNGY-----------------WLDSSTGGMVWRPSPGGDSLEMQKDH 1075

Mouse   983 -------C-CPSNPDPDDRYYNEAGISLYLAQTARGANASGEGPVYSTIDPVGEELQTFHGG--- 1036
                   | .|.:|.........:|        ..|:.|||           |:::...||.   
  Fly  1076 IADYAPVCGAPGSPAGGGTSSGGSG--------GAGSGASG-----------GDDIHGGHGSERN 1121

Mouse  1037 ---FPQHSSGDPSTWSQY-----APPEWSEGDSGARGGQGKLLGKPVQMPSLSWPEALPPPPPSC 1093
               :....|..|:.:::.     ||.|:     |..|                  .|.|.|..:.
  Fly  1122 QQRYVGEYSNIPTDYAEVSSFGKAPSEY-----GRHG------------------NASPAPYATS 1163

Mouse  1094 ELSCPEGPEEELKGSSDLEEWCPPVPEKSHLVGSSSSGACMVAPAPRDTPSPTSSYG-------- 1150
            .:..|...:::.:                                ||....|...||        
  Fly  1164 SILSPHQQQQQQQ--------------------------------PRYQQRPVPGYGLQRPMHPH 1196

Mouse  1151 ------QQSTATLTPSPPDPPQ-----PPTDIPHLHQMPRRVPL-----GPSSPLSVSQPALSSH 1199
                  ||..|..|.......|     ||::|  ..||.....:     |||..:...|......
  Fly  1197 YQQQQHQQQQAQQTHQQHQALQQHQQLPPSNI--YQQMSTTSEIYPTNTGPSRSVYSEQYYYPKD 1259

Mouse  1200 DGRPVGLGAGPVLSYHASPSPVPSTASSAPGRTRQVTGEMTPPLHGHRARIRKK--PKALPYRRE 1262
            ..|.:.:....:.:.|        |..:|||      .:.:.|:....|.:|::  |......||
  Fly  1260 KQRHIHITENKLSNCH--------TYEAAPG------AKQSSPISSQFASVRRQQLPPNCSIGRE 1310

Mouse  1263 HSP---------------------------------GDLPPPPLPPPEEETSWPLGLRAAGSMSS 1294
            .:.                                 |..|.|.......|....|...|.|.:..
  Fly  1311 SARFKVLNTDQGKNQQNLLDLDGSSMCYNGLADSGCGGSPSPMAMLMSHEDEHALYHTADGDLDD 1375

Mouse  1295 LER------ERSGERRVVQAVPLGAQPLGAQRGPHPDAALL----------------GCAAEEAW 1337
            :||      |:...::..|.:||..|        ||....|                .|..|.:.
  Fly  1376 MERLYVKVDEQQPPQQQQQLIPLVPQ--------HPAEGHLQSWRNQSTRSSRKNGQECIKEPSE 1432

Mouse  1338 LPYGRPSFLSHGQGTSTCSTAGSNSSRGSN-------SSRGSRGSRGPGRSRSRSRSQSQSQRPG 1395
            |.|...|..|.....|...:..|:...|.|       ||.|...|:...:|:|:|..|||.|...
  Fly  1433 LIYAPGSVASERSLLSNSGSGTSSQPAGHNVXPLLPGSSLGQSQSKSQSQSQSQSDLQSQEQLYA 1497

Mouse  1396 RNRRE 1400
            |..||
  Fly  1498 REVRE 1502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Robo3XP_006510170.1 Ig 64..162 CDD:386229 45/97 (46%)
Ig 170..254 CDD:386229 36/86 (42%)
Ig 275..343 CDD:386229 30/69 (43%)
Ig4_Robo 361..450 CDD:143203 26/96 (27%)
Ig 451..531 CDD:386229 36/86 (42%)
FN3 564..649 CDD:238020 36/97 (37%)
FN3 678..761 CDD:238020 20/109 (18%)
FN3 771..864 CDD:238020 27/97 (28%)
robo2NP_001259868.1 Ig1_Robo 90..185 CDD:143317 45/98 (46%)
I-set 91..184 CDD:254352 45/96 (47%)
I-set 190..279 CDD:254352 38/89 (43%)
Ig2_Robo 193..279 CDD:143201 36/86 (42%)
I-set 283..370 CDD:254352 35/86 (41%)
Ig 300..370 CDD:299845 30/69 (43%)
Ig 388..>457 CDD:299845 24/74 (32%)
I-set 479..561 CDD:254352 36/86 (42%)
Ig 496..561 CDD:143165 25/69 (36%)
FN3 588..681 CDD:238020 41/92 (45%)
FN3 <817..856 CDD:238020 1/38 (3%)
fn3 864..952 CDD:278470 26/89 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 104 1.000 Domainoid score I6680
eggNOG 1 0.900 - - E1_KOG4222
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101537
Panther 1 1.100 - - O PTHR12231
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X493
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
98.770

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