Protein Alignment Rb1 and Rbf2

DIOPT Version :10

• Sequence 1: NP_033055.2
• Gene: Rb1 / 19645
• MGIID: 97874
• Length: 921
• Species: Mus musculus
• Sequence 2: NP_524372.1
• Gene: Rbf2 / 41941
• FlyBaseID: FBgn0038390
• Length: 783
• Species: Drosophila melanogaster
• Alignment Length: 916
• Identity: 176/916 - (19%)
• Similarity: 345/916 - (37%)
• Gaps: 295/916 - (32%)

Mouse    41 LEFEEIE-EPE-----FIALCQKLKVPDHVRERAWLTWEKVSSVDGILEGYIQKKKELWGICIFI 99
            :|..|:| |.|     |...|::|::...:::.|..|:.::.:|:|:...  :...:.|..|.
  Fly     1 METCEVEGEAETLVRRFSVSCEQLELEARIQQSALSTYHRLDAVNGLSTS--EADAQEWLCCA-- 61

Mouse   100 AAVDLDEMPFTFTELQKSIETSVYKFFDLLKEIDTSTKVDN---------AMSRLLKKYNVLCAL 155
                      .::|||:|      |..|:.:.|:.:.  |:         :::|||:.:.:..:.
  Fly    62 ----------VYSELQRS------KMRDIRESINEAN--DSVAKNCCWNVSLTRLLRSFKMNVSQ 108

Mouse   156 YSKLERTCELIYLTQPSSALSTEINSM-------------------------------------- 182
            :  |.|.....:|||..:....|:..:
  Fly   109 F--LRRMEHWNWLTQNENTFQLEVEELRCRLGITSTLLRHYKHIFRSLFVHPGKGADPGAANHYQ 171

Mouse   183 LVLKISWITFLLAKGEVLQME-DDLVISFQLMLCVVDYF----IKFSPPALLREPYKTAAIPING 242
            .:.:..|:.||:.:.|:.... .:|:...|:::|.:|..    ::.....::|..:  :.:|.|.
  Fly   172 ALYEFGWLLFLVIRNELPGFAITNLINGCQVLVCTMDLLFVNALEVPRSVVIRREF--SGVPKNW 234

Mouse   243 S----------------------PRTPRRG--QNRSARIAKQL----------ENDTRIIEVLCK 273
            .                      |..|.:|  |.::|...|.|          .:||.:.|:: |
  Fly   235 DTEDFNPILLNKYSVLEALGELIPELPAKGVVQMKNAFFHKALIMLYMDHSLVGDDTHMREII-K 298

Mouse   274 EHECNIDEVKNVYFKNFIPFINSLGIVSSNGLPEVESLSKRYEEVYLKNKDLDARLFLDHDKTLQ 338
            |                       |::..|    :|:|:::|........::|.|:.|.....::
  Fly   299 E-----------------------GMLDIN----LENLNRKYTNQVADISEMDERVLLSVQGAIE 336

Mouse   339 T------DPIDSFETERTPRKNNPDEEANVVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISY 397
            |      .|..:|:|..:|      ....:.|...|....::.|:..      ...:.::.:::|
  Fly   337 TKGDSPKSPQLAFQTSSSP------SHRKLSTHDLPASLPLSIIKAF------PKKEDADKIVNY 389

Mouse   398 FNNCTVNPKENILKRVKDVGHIFKEKFANAVGQGCVDIGVQRYKLGVRLYYRVMESMLKSEEERL 462
            .:.............|||        |.:|      ::..:|::....|||:.::.:|..|..:.
  Fly   390 LDQTLEEMNRTFTMAVKD--------FLDA------ELSGKRFRQARGLYYKYLQKILGPELVQK 440

Mouse   463 SIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTLQHLDSGTDLSFPWILNVLNLKAFDFYKVIE 527
            ......:|:.......:||||.||:.:..:.:     |..|  |.||::|:..:|.|:||.|::|
  Fly   441 PQLKIGQLMKQRKLTAALLACCLELALHVHHK-----LVEG--LRFPFVLHCFSLDAYDFQKILE 498

Mouse   528 SFIKVEAN-LTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGPDNLEPACPLSLPLQG 591
            ..::.:.. |.||:||||:..|...::||.:...|.|:..:.|
  Fly   499 LVVRYDHGFLGRELIKHLDVVEEMCLDSLIFRKSSQLWWELNQ---------------------- 541

Mouse   592 NHTAADMYLSPLRSPKKRTSTTRVNSAANTETQAASAFHTQKPLKSTSLALFYKKVYRLAYLRLN 656
                        |.|:.:        ..:.||:....|       ||..::..:|.|.||..||.
  Fly   542 ------------RLPRYK--------EVDAETEDKENF-------STGSSICLRKFYGLANRRLL 579

Mouse   657 TLCAR--LLSDHPELEHIIWTLFQH--TLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKII 717
            .||..  |:...|:    ||.|.:|  ||::. .|:|:|||||:::|:::...:::.:.|.|.:|
  Fly   580 LLCKSLCLVDSFPQ----IWHLAEHSFTLESS-RLLRNRHLDQLLLCAIHLHVRLEKLHLTFSMI 639

Mouse   718 VTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRL-------------------KTNI-- 761
            :..|:..||..:..::.|.:...:...||.|||||::|.:                   ::|:
  Fly   640 IQHYRRQPHFRRSAYREVSLGNGQTADIITFYNSVYVQSMGNYGRHLECAQTRKSLEESQSNVGI 704

Mouse   762 --------------LQYASTRPPTL----SPIPHIPRSPYKFSSSPL---------RIPGGNIYI 799
                          :..:|..||.:    |...|.|.||   ::|||         |....|..:
  Fly   705 LTETTSNELSMRANISISSPPPPRVCQSGSCSSHPPSSP---AASPLSLQSSPNVKRAASSNDLM 766

Mouse   800 SPLKSP 805
            ..:|.|
  Fly   767 REIKRP 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rb1	NP_033055.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		DUF3452	112..221	CDD:463402	25/160 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..360		4/18 (22%)
		Pocket, binds T and E1A. /evidence=ECO:0000250	367..764		93/436 (21%)
		Domain A. /evidence=ECO:0000250	367..573		46/206 (22%)
		RB_A	367..567	CDD:460364	45/200 (23%)
		Spacer. /evidence=ECO:0000250	574..632		5/57 (9%)
		Domain B. /evidence=ECO:0000250	633..764		42/169 (25%)
		CYCLIN_RB	638..764	CDD:410302	41/164 (25%)
		Interaction with LIMD1. /evidence=ECO:0000250	756..921		16/98 (16%)
		Rb_C	761..918	CDD:462639	15/74 (20%)
		Domain, mediates interaction with E4F1. /evidence=ECO:0000250	764..921		15/55 (27%)
		Bipartite nuclear localization signal. /evidence=ECO:0000269|PubMed:8336704	853..869
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	872..921
Rbf2	NP_524372.1	DUF3452	83..213	CDD:463402	18/131 (14%)
		RB_A	<384..536	CDD:460364	42/172 (24%)
		RB_B	<593..679	CDD:460363	29/90 (32%)