DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EIF1AX and eIF1A

DIOPT Version :9

Sequence 1:	NP_001403.1	Gene:	EIF1AX / 1964	HGNCID:	3250	Length:	144	Species:	Homo sapiens
Sequence 2:	NP_001287386.1	Gene:	eIF1A / 44260	FlyBaseID:	FBgn0026250	Length:	148	Species:	Drosophila melanogaster

Alignment Length:	148	Identity:	115/148 - (77%)
Similarity:	126/148 - (85%)	Gaps:	4/148 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKL 65
            ||||||||||||||||||||.|||||:||||.||||||.||||||||||||||||||||||||||
  Fly     1 MPKNKGKGGKNRRRGKNENEFEKRELIFKEDQQEYAQVTKMLGNGRLEAMCFDGVKRLCHIRGKL 65

Human    66 RKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTF-GPGDDDEI 129
            |||||||..||||||||||||:||||||||..||||:||.|||.||..:||||.|| ..|.|::|
  Fly    66 RKKVWINQGDIILVGLRDYQDSKADVILKYTPDEARNLKTYGEFPESVRINETVTFVEDGFDEDI 130

Human   130 QF-DDIG--DDDEDIDDI 144
            :| |:|.  ||.:.:|:|
  Fly   131 EFGDEISSEDDADSVDNI 148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EIF1AX	NP_001403.1	PTZ00329	1..131	CDD:185558	108/130 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		23/24 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..144		15/33 (45%)
eIF1A	NP_001287386.1	PTZ00329	1..147	CDD:185558	113/145 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155205
Domainoid	1	1.000	119	1.000	Domainoid score	I5810
eggNOG	1	0.900	-	-		E1_COG0361
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3470
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54096
OrthoDB	1	1.010	-	-		D1426335at2759
OrthoFinder	1	1.000	-	-		FOG0000631
OrthoInspector	1	1.000	-	-		otm41457
orthoMCL	1	0.900	-	-		OOG6_100738
Panther	1	1.100	-	-	LDO	PTHR21668
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R590
SonicParanoid	1	1.000	-	-		X376
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800