Protein Alignment EHHADH and Srlp

DIOPT Version :10

• Sequence 1: NP_001957.2
• Gene: EHHADH / 1962
• HGNCID: 3247
• Length: 723
• Species: Homo sapiens
• Sequence 2: NP_650199.1
• Gene: Srlp / 41533
• FlyBaseID: FBgn0038049
• Length: 378
• Species: Drosophila melanogaster
• Alignment Length: 336
• Identity: 82/336 - (24%)
• Similarity: 128/336 - (38%)
• Gaps: 71/336 - (21%)

Human    11 LALIRLRNPPV-NAISTTLLRDIKEGLQKAVIDHTIKAIVICGAEGKFSAGADIRGFSAPRTFGL 74
            :.||.:..|.. |||.:.....:.:.......|.|....|:.|..|.|.:|.||...|......:
  Fly    57 ITLIGINRPQQRNAIDSLTASQLCDAFANFEADDTSPVAVLYGVGGSFCSGFDILEISTDEKEEI 121

Human    75 TLGHVVDEIQRNE-----------KPVVAAIQGMAFGGGLELALGCHYRIAHAEAQVGLPEVTLG 128
            :    ||.:.|.|           ||||..|.|.....||||||.|..|:....|.:|......|
  Fly   122 S----VDILMRPEGSVGPTRRQIKKPVVCGINGYCIANGLELALMCDLRVMEESAVLGFFNRRFG 182

Human   129 LLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKLGILDKVV-------------------- 173
            :.....||..||.:.|:..|||||.:||.:.:.||..:|:::::|
  Fly   183 VPMLDAGTIRLPAMIGLSRALDLILTGRPVGSQEAHDIGLVNRIVPTGTALGNALELATCLAKFP 247

Human   174 --------NS--DPVEEAIRFAQRVSDQPLESRRLCNKPIQSLPNMDSIFSEAL--------LKM 220
                    ||  ....|...|.|.|.::.:.:.|   :.|:.:.|....|::..        ||.
  Fly   248 QRALIHDRNSVYSSTFETSTFHQAVQNEVMFTSR---EIIEDMQNGIKWFNQTFKPDTTHSWLKR 309

Human   221 RRQHPGCLAQEACVRAVQAAVQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAERKANKWSTPS 285
            .|.    :|........:||.|   :..:|:|:|..|     .:|...:.|..|::::.|  |..
  Fly   310 DRS----MADWDDEEVAEAAAQ---KEKLKQEQEAAL-----AEAEKQKQAEKAQKRSKK--TEE 360

Human   286 GASWKTASARP 296
            .|:....|..|
  Fly   361 SAAESVDSKDP 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EHHADH	NP_001957.2	Enoyl-CoA hydratase / isomerase	1..282		78/320 (24%)
		fadJ	20..705	CDD:236864	79/327 (24%)
		3-hydroxyacyl-CoA dehydrogenase	283..572		4/14 (29%)
		Microbody targeting signal	721..723
Srlp	NP_650199.1	crotonase-like	49..259	CDD:474030	55/205 (27%)