Protein Alignment EGR4 and egr4

DIOPT Version :10

• Sequence 1: NP_001956.4
• Gene: EGR4 / 1961
• HGNCID: 3241
• Length: 486
• Species: Homo sapiens
• Sequence 2: NP_001107925.1
• Gene: egr4 / 795099
• ZFINID: ZDB-GENE-080204-90
• Length: 352
• Species: Danio rerio
• Alignment Length: 520
• Identity: 151/520 - (29%)
• Similarity: 199/520 - (38%)
• Gaps: 208/520 - (40%)

Human     1 MLHLSEFSEPDAL----LVKSTEGCCAEPSAELPRLPARDAPAATGYPGAGDFLSWALNSCGASG 61
            ||:..:||..|.|    |.:....|  :|.|....|..:..|...|:|           .|...|
Zfish     1 MLNTVDFSALDLLCAQTLPQPAPHC--QPDAACGLLKPKAEPVDAGFP-----------DCSCDG 52

Human    62 DLADSCFLEGPAPTPPPGLSYSGSFFIQAVPEHPHDPEALFNLMSGILGLAP-FPGPEAAASRSP 125
                         .||..|:|:|||:.::   .|...:||.|:::.|:|::. |.|...|.:.|.
Zfish    53 -------------FPPSPLTYTGSFYTES---GPCSTDALLNILTEIVGISDNFCGNSRAGALSR 101

Human   126 LDAPFPAGSDALLPGPPDLYSPDLGAAPFPEAFWEASPCAGAPSQCLYEPQLSPPDVKPGLRAPP 190
            .::....||
Zfish   102 QESLLSTGS-------------------------------------------------------- 110

Human   191 ASPALDAVSAFKGPYAPWELLSVGAPGN-CGSQGDYQAAPEARFPVIGTKIEDLLSISCPAELPA 254
                                 |:|:|.: |....|                          |...
Zfish   111 ---------------------SLGSPESLCNDSSD--------------------------EFAD 128

Human   255 VPANRLYPSGAYDAFPLAPGDLGEGAEGLPGLLTPPSGEGGSSGDGGEFLAST-QPQ-------- 310
            ..|.:|       |||....:.|.            |..||...||  |..|: :|.
Zfish   129 TSAQQL-------AFPAIKSEFGS------------SCSGGDLFDG--FCTSSHEPSDLDDIIDL 172

Human   311 LSPLGLRSAAAADF---PKPLVADIPGSSGVAAPPVPPPPP------TPFPQA------------ 354
            |||||..:.:..|.   .:||...:         ||.|.|.      ..||.|
Zfish   173 LSPLGPETDSVLDTWIKQEPLDFQL---------PVAPAPSHENSLYISFPNAFGLADALDSLLA 228

Human   355 ---KARRKGRRGGKCSTRCFCPRPHAKAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICL 416
               .|:|...|..|.:.|       .|.|:||||||.|.|:||||||||:||||||||||||:||
Zfish   229 TNTHAQRSKPRARKGAAR-------EKPFSCPVESCERRFSRSDELNRHVRIHTGHKPFQCRVCL 286

Human   417 RNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKGLGFYSLGL 481
            |.||||||||||:|||||||||:||||.||||||||:|||.:|||||:.|.:::.:.||..:..|
Zfish   287 RCFSRSDHLTTHMRTHTGEKPFSCDVCARRFARSDERKRHMRVHLKQRERMQQKTELLGACAFSL 351

Human   482  481
            Zfish   352  351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EGR4	NP_001956.4	PHA03247	<74..339	CDD:223021	47/278 (17%)
		zf-C2H2	380..404	CDD:395048	18/23 (78%)
		C2H2 Zn finger	382..404	CDD:275368	17/21 (81%)
		COG5048	408..>466	CDD:227381	48/57 (84%)
		C2H2 Zn finger	412..432	CDD:275368	16/19 (84%)
		C2H2 Zn finger	440..460	CDD:275368	15/19 (79%)
egr4	NP_001107925.1	C2H2 Zn finger	252..274	CDD:275368	17/21 (81%)
		COG5048	278..>344	CDD:227381	49/65 (75%)
		C2H2 Zn finger	282..302	CDD:275368	16/19 (84%)
		zf-H2C2_2	294..319	CDD:463886	21/24 (88%)
		C2H2 Zn finger	310..330	CDD:275368	15/19 (79%)