Protein Alignment PLPP4 and laza

DIOPT Version :10

• Sequence 1: NP_001025230.1
• Gene: PLPP4 / 196051
• HGNCID: 23531
• Length: 271
• Species: Homo sapiens
• Sequence 2: NP_649391.1
• Gene: laza / 40468
• FlyBaseID: FBgn0037163
• Length: 334
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 81/286 - (28%)
• Similarity: 116/286 - (40%)
• Gaps: 71/286 - (24%)

Human    39 YKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIR---------------RTDKTEIKEAFLAVS 88
            ||:..:   .:|..|:..:  |.|:..:.||:|:|               |.:.| ....|:|..
  Fly    19 YKDCTI---TVPMLLLMML--LLPMLFVAVVEIMRICKRFRTRLYFRNLWRAEAT-FSFGFIATY 77

Human    89 LALALNGVCTNTIKLIVGRPRPDFFYRCFP---DG-----VMNSEM-----HCTGD---PDLVSE 137
            |.       |...|..|||.||.||:.|.|   ||     :.|:|:     |||.:   ...:.|
  Fly    78 LT-------TELAKHAVGRLRPHFFHGCQPRLDDGSSCSDLQNAELYVEQFHCTNNNLSTRQIRE 135

Human   138 GRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRG--KSWRLCAAILPLYCAMMIALSRMCDY 200
            ...||||.|||.:|..:.....|:.|     ...|||  :..|.....|.|..|:.::|||:.||
  Fly   136 LHVSFPSAHSSLSFYSMVLLALYVHG-----VWRGRGGVRVLRHVLQFLLLMAALCVSLSRVADY 195

Human   201 KHHWQDSFVGGVIGLIFAYI--CY------RQ-----HYPPLANTACHKPYVSL----RVPASLK 248
            .|||.|...|.::|:.:|.|  .|      ||     ..||..|.:.|..:..:    ...||.|
  Fly   196 WHHWSDVLAGALLGVTYAAITAAYVGNLLRRQTSSTGRIPPSLNYSHHLHHQLMADNNNSTASAK 260

Human   249 KEERPTADSA---PSLPLEGITEGPV 271
            ......|.||   .:.||:.|.:..|
  Fly   261 VHFLAAAASASMTTTTPLDDIQDSDV 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLPP4	NP_001025230.1	PAP2_containing_1_like	37..225	CDD:239484	67/231 (29%)
		Phosphatase sequence motif I. /evidence=ECO:0000269|PubMed:17590538	102..110		4/7 (57%)
		Phosphatase sequence motif II. /evidence=ECO:0000269|PubMed:17590538	143..146		2/2 (100%)
		Phosphatase sequence motif III. /evidence=ECO:0000269|PubMed:17590538	195..205		6/9 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..271		6/23 (26%)
laza	NP_649391.1	PAP2_wunen	62..217	CDD:239479	54/167 (32%)