Protein Alignment AHR and sima

DIOPT Version :10

• Sequence 1: NP_001612.1
• Gene: AHR / 196
• HGNCID: 348
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_001287599.1
• Gene: sima / 43580
• FlyBaseID: FBgn0266411
• Length: 1593
• Species: Drosophila melanogaster
• Alignment Length: 982
• Identity: 209/982 - (21%)
• Similarity: 348/982 - (35%)
• Gaps: 288/982 - (29%)

Human    32 KSNPSKRHRDRLNTEL-DRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERN 95
            ||..:.|.|....||: ..|::.||...|.:|:|||.||:|:::::|:.:..    |:..|:.|:
  Fly   162 KSRDAARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREM----LQFVPSLRD 222

Human    96 GGQD---NCRAANFREGL--NLQEG-----------EFLLQALNGFVLVVTTDALVFYASSTIQD 144
            ...|   :...|..::.:  .|:.|           |.|.|.::||:||::.:..:.|.|..:.:
  Fly   223 CNDDIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVE 287

Human   145 YLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIP 209
            |||..:.|.:.|.::|..|..|.||                    |:||..|.:.:.....|: |
  Fly   288 YLGITKIDTLGQQIWEYSHQCDHAE--------------------IKEALSLKRELAQKVKDE-P 331

Human   210 PENSPLM--ERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLA 264
            .:||.:.  .|....||:|.|.:        |:.:..::..|.|..    ..||        :..
  Fly   332 QQNSGVSTHHRDLFVRLKCTLTSRGRSINIKSASYKVIHITGHLVV----NAKG--------ERL 384

Human   265 LFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAAD 329
            |.||..|:..||.:||......|.|||.||......|.|...:|||:..:|... |.:...|.||
  Fly   385 LMAIGRPIPHPSNIEIPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDT-SLFSCQHGAD 448

Human   330 MLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKNGRP------DYII-------- 380
            ......:...::..|:.....:|.|.|...:.|:.|.|.::|...:|      :|:|
  Fly   449 SERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKLKPQSVVCVNYVISNLENKHE 513

Human   381 ---VTQRPLTDEEGTEHLRKRNT-KLPFMFTTGEAVLYEA------------------------- 416
               :.|:....|:..:|.:...| |.|......|.:..|.
  Fly   514 IYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQAKPLQLESEKA 578

Human   417 ------------------------------TNPFPAIMD-PLPLRTKNGTSGKDSATTSTLSKDS 450
                                          :||:..|:. .|.::.:|.:.|..:.|...||..|
  Fly   579 EKTIEETKTIATIPPVTATSTADQIKQLPESNPYKQILQAELLIKRENHSPGPRTITAQLLSGSS 643

Human   451 -------LNPSSLLAAMMQQDESIYLYP------------------ASSTSSTAPFENNFFNESM 490
                   ..|.|:.|::::...:..|.|                  ..:|::||...:: .|:.:
  Fly   644 SGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKTPLGVEPNLPPTTTATAAIISS-SNQQL 707

Human   491 NECRNWQDNTAPMGNDTILKHEQIDQPQD-VNSFAGGHPGLFQDSKNSDLYSIMKNLGIDFEDIR 554
            .                |.:..|:..||. ....:.|...||.|....  .:::|....|..  .
  Fly   708 Q----------------IAQQTQLQNPQQPAQDMSKGFCSLFADDGRG--LTMLKEEPDDLS--H 752

Human   555 HMQNEKFFRND----FSGEV-----------DFRDIDLTDEILT----YVQDSLSKSPFIPSDYQ 600
            |:.:....:.|    ||..:           |...:|.|....|    :.|...|.|...||:..
  Fly   753 HLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTSAPSNTS 817

Human   601 QQQS---------LALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNS 656
            ...:         |..||:.......| :||||||.:|     |||..|:..|.|.:   :|.||
  Fly   818 SSNNSYANSPLSPLTPNSTATASNPSH-QQQQQHHNQQ-----QQQQQQQQHHPQHH---DNSNS 873

Human   657 NQFVP--FNCPQQDPQQYNVFTDLH--GISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTEL 717
            :..:.  ||. :::....:....||  .|:.:.|..|.:.|:        |:...|.|     |.
  Fly   874 SSNIDPLFNY-REESNDTSCSQHLHSPSITSKSPEDSSLPSL--------CSPNSLTQ-----ED 924

Human   718 DYPMGSFEP----SPY-PTTSSL-----EDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMY 772
            |:   |||.    :|| |....:     .|.:.|  .||:.:        .:.|:...|....:.
  Fly   925 DF---SFEAFAMRAPYIPIDDDMPLLTETDLMWC--PPEDLQ--------TMVPKEIDAIQQQLQ 976

Human   773 QCQPEPQHTHVG-----QMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQP--- 829
            |.|.:....:.|     |.|..|.|..|.     |.|.:.:.  ||        .|.:.|.|
  Fly   977 QLQQQHHQQYAGNTGYQQQQQQPQLQQQH-----FSNSLCSS--PA--------STVSSLSPSPV 1026

Human   830 -LHHPSE 835
             .||..:
  Fly  1027 QQHHQQQ 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AHR	NP_001612.1	bHLH-PAS_AhR	28..88	CDD:381442	18/56 (32%)
		PAS	113..226	CDD:395786	31/125 (25%)
		PAS_3	297..382	CDD:430001	21/101 (21%)
sima	NP_001287599.1	bHLH-PAS_HIF	159..216	CDD:381439	19/57 (33%)
		PAS	256..392	CDD:395786	40/168 (24%)
		PAS	265..>317	CDD:238075	18/71 (25%)
		PAS	404..505	CDD:238075	26/101 (26%)