Protein Alignment AHR and tgo

DIOPT Version :10

• Sequence 1: NP_001612.1
• Gene: AHR / 196
• HGNCID: 348
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_731308.1
• Gene: tgo / 41084
• FlyBaseID: FBgn0264075
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 712
• Identity: 155/712 - (21%)
• Similarity: 251/712 - (35%)
• Gaps: 225/712 - (31%)

Human     6 ANI----TYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDK 66
            |||    .:|||:....::                :|.|:::...:..|:.::|....:..|.||
  Fly     4 ANIQDKERFASRENHCEIE----------------RRRRNKMTAYITELSDMVPTCSALARKPDK 52

Human    67 LSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTT 131
            |::||::|::::       ||:.:   .|...|.....:|.....|:  ..:|:|.:||:.||:.
  Fly    53 LTILRMAVAHMK-------ALRGT---GNTSSDGTYKPSFLTDQELK--HLILEAADGFLFVVSC 105

Human   132 DA-LVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATG 195
            |: .|.|.|.::...|.:.|||....|:||.||.:||.:.:.||        .|:..|.......
  Fly   106 DSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQL--------STQESQNAGRILD 162

Human   196 LPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLH--GQKKKGKDGSI 258
            |....|.....|.....|....|.||||:|....|....::.:. .:||..:  |..:.|.:.::
  Fly   163 LKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMVSGHL-NRLKQRNSLGPSRDGTNYAV 226

Human   259 L---------PP------------------QLALFAIATPLQPPSI----LEIRTKNFIFRTKHK 292
            :         ||                  ...|.||.. ||..|.    :........|.|:|.
  Fly   227 VHCTGYIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGR-LQVTSTAANDMSGSNNQSEFITRHA 290

Human   293 LD--FTPIGCDAKGRIVLGYTEAEL----CTRGSGYQFIHAADMLYCAESHIRMIK-TGESGMIV 350
            :|  ||.:  |.:...:||||..||    |     |.|.|..|..:..||..:::| .|:...::
  Fly   291 MDGKFTFV--DQRVLNILGYTPTELLGKIC-----YDFFHPEDQSHMKESFDQVLKQKGQMFSLL 348

Human   351 FRLLTKNNRWTWVQSNARLLYKNGRP-----DYIIVTQ--------RPL------TDEE------ 390
            :|...||:.:.|:::.|   |....|     :||:.|.        .||      |.|:
  Fly   349 YRARAKNSEYVWLRTQA---YAFLNPYTDEVEYIVCTNSSGKTMHGAPLDAAAAHTPEQVQQQQQ 410

Human   391 -----------GTEHLRKRNTKL-----PFMF--------------------------TTGEAVL 413
                       |.::.|:..|.:     ..|:                          ||.....
  Fly   411 QEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYT 475

Human   414 YEAT-NPFPAIMDPLPLR--TKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESI---YLY-- 470
            |:.| :|:.| ..|.||.  .|:|||....|..|..   :|.|..    ..||.:.:   |.|
  Fly   476 YDTTHSPYSA-GGPSPLAKIPKSGTSPTPVAPNSWA---ALRPQQ----QQQQQQPVTEGYQYQQ 532

Human   471 --PASSTSSTAPFENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQPQDVNS-------FAGG 526
              ||.|.|.....:.:..|.:..:.:.......|              |...|:       .|||
  Fly   533 TSPARSPSGPTYTQLSAGNGNRQQAQPGAYQAGP--------------PPPPNAPGMWDWQQAGG 583

Human   527 HP----------------------GLFQDSKNSDLYSIMKNLGIDFEDIRHMQNEKFFRNDF 566
            ||                      |..|..:.||:..::.:....|||:    |...|...|
  Fly   584 HPHPPHPTAHPHHPHAHPGGPAGAGQPQGQEFSDMLQMLDHTPTTFEDL----NINMFSTPF 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AHR	NP_001612.1	bHLH-PAS_AhR	28..88	CDD:381442	12/59 (20%)
		PAS	113..226	CDD:395786	34/113 (30%)
		PAS_3	297..382	CDD:430001	25/94 (27%)
tgo	NP_731308.1	bHLH-PAS_ARNT	9..74	CDD:381517	17/90 (19%)
		PAS	90..154	CDD:214512	24/71 (34%)
		PAS_11	282..384	CDD:464214	32/111 (29%)