Protein Alignment AHR and gce

DIOPT Version :10

• Sequence 1: NP_001612.1
• Gene: AHR / 196
• HGNCID: 348
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_511160.2
• Gene: gce / 32457
• FlyBaseID: FBgn0261703
• Length: 959
• Species: Drosophila melanogaster
• Alignment Length: 761
• Identity: 155/761 - (20%)
• Similarity: 275/761 - (36%)
• Gaps: 206/761 - (27%)

Human    32 KSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAK-SFFDVALKSSPTERN 95
            ::...|..||:||..:..|::::|...:...::||.:|||.:...||.| :|.:..::..|
  Fly   282 RNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAAHALRLKHAFGNSLMQQRP---- 342

Human    96 GGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYE 160
                             |..:.|:..|:.|.|.:|....:...|::|:.:||..|||:..||:.:
  Fly   343 -----------------QITDTLMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYGQSIMQ 390

Human   161 LIHTEDRAEFQRQLHWALNPSQCTE--SGQGIEEATGLPQTVVCYNPDQIP-------------- 209
            :.|.||    |..|...|.|::...  ...|..:|.|.|:.......|.|.
  Fly   391 ITHPED----QNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVRL 451

Human   210 ----PENSPL------MERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILP---- 260
                |.:.|.      ::.||    |...:...|..:.:|...|:.:  ::.:|:| .::|
  Fly   452 ARAGPRSEPTAYEVVKIDGCF----RRSDEAPRGVRSNHFSSNLQLI--RRTRGRD-DVIPLHTI 509

Human   261 --PQLALFAIATPLQPPSILE--IRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSG 321
              ..:.|...|..::||.|..  |......::|:|.:|...|.||.:..||.||...|: ...|.
  Fly   510 SGNDIILTGCARIIRPPKIASRLIDANTLEYKTRHLIDGRIIDCDQRIGIVAGYMTDEV-RNLSP 573

Human   322 YQFIHAADMLYCAESHIRMIKTGES-GMIVFRLLTKNNRWTWVQSNARLLY--KNGRPDYIIVTQ 383
            :.|:|..|:.:...:..:|.....| |...:||.|:|....::||...|..  :..:....:...
  Fly   574 FTFMHNDDVRWVIVALRQMYDCNSSYGESTYRLFTRNGNIIYLQSKGYLEIDKETNKVHSFVCVN 638

Human   384 RPLTDEEG---TEHLRKR-----NTKLPFMFTTGEAVLYEATNPFPAIMDPLPLR-----TKNG- 434
            ..|.:|||   .:.::|:     ||::|      ::.:....:..||:::...||     .|:|
  Fly   639 TLLGEEEGKRRVQEMKKKFSVIINTQIP------QSTIDVPASEHPALLEKAVLRLIQNLQKSGE 697

Human   435 TSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTA-PF-----ENNFFNESMNEC 493
            ..|.|.......::|..:..       :.|:......|.|.|... |:     .::..:.:::..
  Fly   698 NGGHDDGDEDDDAQDGDDDE-------EDDDDDQDDGARSMSEFGDPYGSHHGRSHHGSSALSSH 755

Human   494 RNWQDNTAPMG--------------------NDTILKH-------EQIDQPQDVNS--------- 522
            .:....|.|:.                    |.|..||       ..:..|..:.|
  Fly   756 GHGNAKTPPLALVPPEASSVKSAITKSISVVNVTAAKHLRGIHASTAVKSPSSLGSCTCSDSHSP 820

Human   523 --FAGGHPGLFQDSKNSDLYSIMKNL--GIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILT 583
              |..|.|       .:||.::..||  |    ...|::.|
  Fly   821 CDFCQGAP-------TTDLQAVGSNLKRG----STAHVETE------------------------ 850

Human   584 YVQDSLSKSPFIPS----------------DYQQQQSLALNSSCMVQ--EHLHLEQQ----QQHH 626
               :.|||..||||                :..||.::|.|.....|  |..|..|:    .|.|
  Fly   851 ---EKLSKRRFIPSTEIEHVLHTSLDQIGRNLTQQLNVARNLREQSQRYELPHANQRFDEIMQEH 912

Human   627 QKQ--VVVEPQQQLCQKMKHMQVNGMFENWNSNQFVPFNCPQQDPQ 670
            |||  :.|..:.:...:::|........:.:.||..|....|:|.|
  Fly   913 QKQSELYVNIKSEYEVQLQHKASTRKSSDSDRNQEQPPPPLQEDDQ 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AHR	NP_001612.1	bHLH-PAS_AhR	28..88	CDD:381442	16/56 (29%)
		PAS	113..226	CDD:395786	32/138 (23%)
		PAS_3	297..382	CDD:430001	22/87 (25%)
gce	NP_511160.2	bHLH_PAS	279..333	CDD:381397	15/50 (30%)
		PAS	352..>405	CDD:238075	18/56 (32%)
		PAS_11	537..646	CDD:464214	27/109 (25%)