Protein Alignment AHR and Met

DIOPT Version :10

• Sequence 1: NP_001612.1
• Gene: AHR / 196
• HGNCID: 348
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_511126.2
• Gene: Met / 32114
• FlyBaseID: FBgn0002723
• Length: 716
• Species: Drosophila melanogaster
• Alignment Length: 630
• Identity: 129/630 - (20%)
• Similarity: 225/630 - (35%)
• Gaps: 191/630 - (30%)

Human    27 PAEG--IKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKS 89
            ||.|  .::...|:.||:||..:..||:::|...:...:|||.:|||.:...||.:..|.   ||
  Fly    34 PANGREARNLAEKQRRDKLNASIQELATMVPHAAESSRRLDKTAVLRFATHGLRLQYVFG---KS 95

Human    90 SPTERNGGQDNCRAANFREGL----------------NLQEGEFLLQALNGFVLVVTTDALVFYA 138
            :...|.           :.||                :|...:.|:|.|:...|.:|....:...
  Fly    96 ASRRRK-----------KTGLKGTGMSASPVGDLPNPSLHLTDTLMQLLDCCFLTLTCSGQIVLV 149

Human   139 SSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQL-------------------HWALNPSQ-- 182
            |::::..||..|||:..|::.::.|.:|:...::||                   |   ||.|
  Fly   150 STSVEQLLGHCQSDLYGQNLLQITHPDDQDLLRQQLIPRDIETLFYQHQHHQQQGH---NPQQHS 211

Human   183 ----CTESGQGIEE--------ATGLPQTVVCYNPDQIPPEN----SP--------------LME 217
                .:.||..:||        ..|..|...  :.|:..|.|    ||              :..
  Fly   212 TSTSASTSGSDLEEEEMETEEHRLGRQQGEA--DDDEDHPYNRRTPSPRRMAHLATIDDRLRMDR 274

Human   218 RCFICRL--------------RCLLD--------NSSGFLAMNFQGKLKYLHGQKKK-------- 252
            |||..||              |..:|        :.:|..|.|:....:.:...:..
  Fly   275 RCFTVRLARASTRAEATRHYERVKIDGCFRRSDSSLTGGAAANYPIVSQLIRRSRNNNMLAAAAA 339

Human   253 -GKDGSILPPQ----------------LALFAIATPL---QPPSILEIRTKNFIFR--------- 288
             ..:.:.:|||                :.|.|:|..|   :||...|......|:|
  Fly   340 VAAEAATVPPQHDAIAQAALHGISGNDIVLVAMARVLREERPPEETEGTVGLTIYRQPEPYQLEY 404

Human   289 -TKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIK-TGESGMIVF 351
             |:|.:|.:.|.||.:..:|.||.:.|: ...|.:.|:|..|:.:...:..:|.. ..:.|...:
  Fly   405 HTRHLIDGSIIDCDQRIGLVAGYMKDEV-RNLSPFCFMHLDDVRWVIVALRQMYDCNSDYGESCY 468

Human   352 RLLTKNNRWTWVQSNARLLYKNG--RPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTT---GEA 411
            |||::|.|:.::.:...|....|  :....:.....|.:|.|.:.:::...|    |:|   .|.
  Fly   469 RLLSRNGRFIYLHTKGFLEVDRGSNKVHSFLCVNTLLDEEAGRQKVQEMKEK----FSTIIKAEM 529

Human   412 VLYEATNPFPAIMDPLPLR------TKNGTSGKDSATT------------------STLSKDSLN 452
            ....::...||...|..|.      .:|.....|||.|                  :||:.:.|.
  Fly   530 PTQSSSPDLPASQAPQQLERIVLYLIENLQKSVDSAETVGGQGMESLMDDGYSSPANTLTLEELA 594

Human   453 PSSLLAAMMQQDESIYLYPASSTSSTAPFENNFFNESMNECRNWQ 497
            ||...|        :.|.|.:.:|..:....:....::...|.:|
  Fly   595 PSPTPA--------LALVPPAPSSVKSSISKSVSVVNVTAARKFQ 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AHR	NP_001612.1	bHLH-PAS_AhR	28..88	CDD:381442	19/61 (31%)
		PAS	113..226	CDD:395786	36/177 (20%)
		PAS_3	297..382	CDD:430001	20/87 (23%)
Met	NP_511126.2	bHLH_PAS	38..89	CDD:381397	16/50 (32%)
		PAS	137..>186	CDD:238075	12/48 (25%)
		PAS_11	401..510	CDD:464214	25/109 (23%)