DRSC/TRiP Functional Genomics Resources

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Protein Alignment EGR2 and hkb

DIOPT Version :10

Sequence 1:NP_001397860.1 Gene:EGR2 / 1959 HGNCID:3239 Length:489 Species:Homo sapiens
Sequence 2:NP_524221.1 Gene:hkb / 40549 FlyBaseID:FBgn0261434 Length:297 Species:Drosophila melanogaster


Alignment Length:336 Identity:98/336 - (29%)
Similarity:131/336 - (38%) Gaps:97/336 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   144 TASSSVTSASPNPLATGPLGVCTMSQ-TQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATT 207
            |...:.|||:|..:...|..:...:: ......|            .|.||.   .||..||:::
  Fly    21 TQRQAATSAAPRTVKQEPEAITIKTELASSSFGH------------DCDGDF---SSASSSASSS 70

Human   208 STSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVP 272
            |.||...|....::.|....:.| |....| :|.|                ..|...||||    
  Fly    71 SNSSKSCYEEALNHSSYTRTSTP-LLDAAP-HPVF----------------SHPQSSPLDT---- 113

Human   273 PPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSS---AAAAAAAAAAYNPHHLP---LR 331
                             .|..|...|......|.|..:|.   ||||||||||..|..:|   :.
  Fly   114 -----------------HAAATASLAPPNQHAPFLSAASDLYYAAAAAAAAAASTPTAVPGFGMD 161

Human   332 PI---------------------LRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIR 375
            |.                     |..||  .||.|       :.||  .||..||.:.:|..|||
  Fly   162 PFTMGLMEQEYARVMAEDAQLKALNSRK--QRPKK-------FKCP--NCDVAFSNNGQLKGHIR 215

Human   376 IHTGHKPFQCRI--CMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKE 438
            ||||.:||:|.:  |.:.|:|::.||.|.|.|||.:|:.|..||:||.|.|..|:|.|.|:.|: 
  Fly   216 IHTGERPFKCDVNTCGKTFTRNEELTRHKRIHTGLRPYPCSACGKKFGRRDHLKKHMKTHMPQE- 279

Human   439 RKSSAPSASVP 449
             :...||..||
  Fly   280 -RQLGPSIFVP 289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EGR2NP_001397860.1 DUF3446 107..201 CDD:463400 11/57 (19%)
zf-C2H2 353..377 CDD:395048 10/23 (43%)
C2H2 Zn finger 355..377 CDD:275368 10/21 (48%)
COG5048 381..>449 CDD:227381 28/69 (41%)
C2H2 Zn finger 385..405 CDD:275368 8/21 (38%)
C2H2 Zn finger 413..433 CDD:275368 10/19 (53%)
hkbNP_524221.1 COG5048 195..>261 CDD:227381 31/67 (46%)
C2H2 Zn finger 197..217 CDD:275368 10/21 (48%)
C2H2 Zn finger 225..247 CDD:275368 8/21 (38%)
zf-C2H2 253..275 CDD:395048 10/21 (48%)
C2H2 Zn finger 255..275 CDD:275368 10/19 (53%)

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