DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EGR2 and odd

DIOPT Version :9

Sequence 1:	XP_011537729.1	Gene:	EGR2 / 1959	HGNCID:	3239	Length:	489	Species:	Homo sapiens
Sequence 2:	NP_722922.1	Gene:	odd / 33583	FlyBaseID:	FBgn0002985	Length:	392	Species:	Drosophila melanogaster

Alignment Length:	240	Identity:	71/240 - (29%)
Similarity:	93/240 - (38%)	Gaps:	61/240 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   260 KPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYN 324
            :|:|..|.:|...........:....|||  ||    ||||...|  ..|||
  Fly   171 RPYPAGLHSLHAAVMGRHFGAMPTLKLGG--AG----GASGVPSG--ATGSS------------- 214

Human   325 PHHLPLRPILRPR-----KYPNRP----------SKTPVHERPYPCPAEGCDRRFSRSDELTRHI 374
                      ||:     ||.||.          .:|...||||.|  :.|.:.|.|.|.|..|.
  Fly   215 ----------RPKKQFICKYCNRQFTKSYNLLIHERTHTDERPYSC--DICGKAFRRQDHLRDHR 267

Human   375 RIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKER 439
            .||:..|||:|..|.:.|.:|..|..|..||..|.|..|..|.|.|.:....|.|.:.|..|..:
  Fly   268 YIHSKDKPFKCSDCGKGFCQSRTLAVHKVTHLEEGPHKCPICQRSFNQRANLKSHLQSHSEQSTK 332

Human   440 K---SSAPSASVPAPSTASCSGGVQPGG--------TLCSSNSSS 473
            :   :::|:.|...|:.|..|  .||..        .|.||:|||
  Fly   333 EVVVTTSPATSHSVPNQALSS--PQPENLAQHLPVLDLSSSSSSS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EGR2	XP_011537729.1	DUF3446	107..179	CDD:403215
		zf-C2H2	353..377	CDD:395048	8/23 (35%)
		C2H2 Zn finger	355..377	CDD:275368	7/21 (33%)
		COG5048	381..>449	CDD:227381	23/70 (33%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
odd	NP_722922.1	COG5048	<203..334	CDD:227381	48/157 (31%)
		C2H2 Zn finger	222..242	CDD:275368	4/19 (21%)
		zf-H2C2_2	234..259	CDD:290200	8/26 (31%)
		C2H2 Zn finger	250..270	CDD:275368	7/21 (33%)
		zf-H2C2_2	262..285	CDD:290200	9/22 (41%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		zf-C2H2	304..326	CDD:278523	6/21 (29%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030