DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment EGR1 and odd

DIOPT Version :9

Sequence 1:NP_001955.1 Gene:EGR1 / 1958 HGNCID:3238 Length:543 Species:Homo sapiens
Sequence 2:NP_722922.1 Gene:odd / 33583 FlyBaseID:FBgn0002985 Length:392 Species:Drosophila melanogaster


Alignment Length:303 Identity:72/303 - (23%)
Similarity:105/303 - (34%) Gaps:93/303 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   259 QQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSGSQDL-------KALNTSYQSQLI 316
            |||..|.|....|   |......||..:.|.::....|..   |.|       .|:....|.|..
  Fly    91 QQQHRLWLQMQQQ---QQQHQAPQQYPVYPTASADPVAVH---QQLMNHWIRNAAIYQQQQQQQQ 149

Human   317 KPSRMRK--YPNRPSKTPPHERPYACPVES----------------------------------- 344
            .|.....  :|:.|...|.|.|||...:.|                                   
  Fly   150 HPHHHHHHGHPHHPHPHPHHVRPYPAGLHSLHAAVMGRHFGAMPTLKLGGAGGASGVPSGATGSS 214

Human   345 ----------CDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACD 399
                      |:|:|::|..|..|.|.||.::|:.|.||.:.|.|.|||..|...|:.:|||.|.
  Fly   215 RPKKQFICKYCNRQFTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKDKPFKCS 279

Human   400 ICGRKFA------------------------RSDERKRHTKIHLRQKDKKADKSVVASSATSSLS 440
            .||:.|.                        ||..::.:.|.||:...:::.|.||.:::.::..
  Fly   280 DCGKGFCQSRTLAVHKVTHLEEGPHKCPICQRSFNQRANLKSHLQSHSEQSTKEVVVTTSPATSH 344

Human   441 SYPSPVATSYPSPVTTSYPSPATTSYPSPVPTSFSSPGSSTYP 483
            |.|:...:|         |.|...:...||....||..||..|
  Fly   345 SVPNQALSS---------PQPENLAQHLPVLDLSSSSSSSEKP 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EGR1NP_001955.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..105
DUF3446 135..209 CDD:314753
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 165..213
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..284 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 318..339 7/22 (32%)
zf-C2H2 338..362 CDD:306579 9/68 (13%)
C2H2 Zn finger 340..362 CDD:275368 8/66 (12%)
zf-H2C2_2 354..379 CDD:316026 10/24 (42%)
C2H2 Zn finger 370..390 CDD:275368 9/19 (47%)
zf-H2C2_2 382..407 CDD:316026 11/48 (23%)
C2H2 Zn finger 398..418 CDD:275368 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 409..487 18/75 (24%)
DUF3432 447..530 CDD:288743 10/37 (27%)
oddNP_722922.1 COG5048 <203..334 CDD:227381 33/130 (25%)
C2H2 Zn finger 222..242 CDD:275368 7/19 (37%)
zf-H2C2_2 234..259 CDD:290200 10/24 (42%)
C2H2 Zn finger 250..270 CDD:275368 9/19 (47%)
zf-H2C2_2 262..285 CDD:290200 10/22 (45%)
C2H2 Zn finger 278..298 CDD:275368 4/19 (21%)
zf-C2H2 304..326 CDD:278523 5/21 (24%)
C2H2 Zn finger 306..326 CDD:275368 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2698
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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