Protein Alignment EGR1 and hsr1

DIOPT Version :10

• Sequence 1: NP_001955.1
• Gene: EGR1 / 1958
• HGNCID: 3238
• Length: 543
• Species: Homo sapiens
• Sequence 2: NP_593553.1
• Gene: hsr1 / 2543251
• PomBaseID: SPAC3H1.11
• Length: 582
• Species: Schizosaccharomyces pombe
• Alignment Length: 590
• Identity: 132/590 - (22%)
• Similarity: 193/590 - (32%)
• Gaps: 217/590 - (36%)

Human    82 SSSTFNPQADTGEQPYEHLTAESFPD-ISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEP--AP 143
            ::|.|.|...:...|.......|.|. .|.:|..|    :|.......||:..|..|||.|  :|
pombe    22 NTSPFAPAQSSSPLPSNSCREYSLPSHPSTHNSSV----AYVDSQDNKPPLVSTLHFSLAPSLSP 82

Human   144 NSG---NT-LWPEPLFSLVSGLVSMTNPPASSSSAPSPAASSASASQSPPLSCAVPSNDSSPIYS 204
            :|.   || |..|||.|.:.|          :|..||   :|.|.||.|    :...||.|.:.|
pombe    83 SSAQSHNTALITEPLTSFIGG----------TSQYPS---ASFSTSQHP----SQVYNDGSTLNS 130

Human   205 AAPTFPTPNTDIF-PEPQSQAFPG-SAGTALQYPPPA-----------YPAAKGGFQVPMIP--- 253
            ...|....|.:.| |.||:   || |.....||..|:           |...|.|.|..:.|
pombe   131 NNTTQQLNNNNGFQPPPQN---PGISKSRIAQYHQPSQTYDDTVDSSFYDWYKAGAQHNLAPPQS 192

Human   254 -------DYLF---------------------------PQQ---------------QGDLGLGTP 269
                   .|::                           ||:               |.:|....|
pombe   193 SHTEASQGYMYSTNTAHDATDIPSSFNFYNTQASTAPNPQEINYQWSHEYRPHTQYQNNLLRAQP 257

Human   270 D-----------QKPFQG---------------LESRTQQPSLT----PLSTIKAFATQSGSQDL 304
            :           ..|||.               :......|.||    ||||..:..:......:
pombe   258 NVNCENFPTTVPNYPFQQPSYNPNALVPSYTTLVSQLPPSPCLTVSSGPLSTASSIPSNCSCPSV 322

Human   305 KALNTSYQS-----------------------QLIKPS-----RMRKYPNR-------PSKTPPH 334
            |:...||.:                       |.:..|     .|..|.|:       |:.....
pombe   323 KSSGPSYHAEQEVNVNSYNGGIPSTSYNDTPQQSVTGSYNSGETMSTYLNQTNTSGRSPNSMEAT 387

Human   335 ERPYACPVESCDRRFSRSDELTRHIRI--HTGQKPFQCRICMRNFSRSDHLTTHIRT-HTGEKPF 396
            |:......:...:|..|.....|...:  ..|.|.|.|..|.:.|.||:||..|||: ||.||||
pombe   388 EQIGTIGTDGSMKRRKRRQPSNRKTSVPRSPGGKSFVCPECSKKFKRSEHLRRHIRSLHTSEKPF 452

Human   397 ACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSP 461
            .| |||::|:|.|..::|.::|:              :|:..|:.:..|  :.|       |.|.
pombe   453 VC-ICGKRFSRRDNLRQHERLHV--------------NASPRLACFFQP--SGY-------YSSG 493

Human   462 ATTSYPSPVPTSFSSPGSSTYPS---------PVHSGFPSPSVATT---YSSVPP---AFPAQVS 511
            |              ||:...|.         |::.|..|..:..|   .||..|   ....:::
pombe   494 A--------------PGAPVQPQKPIEDLNKIPINQGMDSSQIENTNLMLSSQRPLSQQIVPEIA 544

Human   512 SFPSS 516
            ::|:|
pombe   545 AYPNS 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EGR1	NP_001955.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		4/22 (18%)
		DUF3446	135..237	CDD:463400	37/109 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..213		13/47 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..284		5/45 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..339		6/32 (19%)
		zf-C2H2	338..362	CDD:395048	3/25 (12%)
		C2H2 Zn finger	340..362	CDD:275368	3/23 (13%)
		zf-H2C2_2	354..379	CDD:463886	7/26 (27%)
		C2H2 Zn finger	370..390	CDD:275368	10/20 (50%)
		zf-H2C2_2	382..407	CDD:463886	16/25 (64%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..487		14/86 (16%)
		DUF3432	447..530	CDD:403204	16/85 (19%)
hsr1	NP_593553.1	COG5048	103..582	CDD:227381	106/505 (21%)
		C2H2 Zn finger	425..446	CDD:275368	10/20 (50%)
		C2H2 Zn finger	454..473	CDD:275368	8/19 (42%)