Protein Alignment EGR1 and egr1

DIOPT Version :10

• Sequence 1: NP_001955.1
• Gene: EGR1 / 1958
• HGNCID: 3238
• Length: 543
• Species: Homo sapiens
• Sequence 2: NP_001090830.1
• Gene: egr1 / 100038164
• XenbaseID: XB-GENE-853412
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 546
• Identity: 378/546 - (69%)
• Similarity: 430/546 - (78%)
• Gaps: 50/546 - (9%)

Human     1 MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNGAPQFLGAAGAPEGSGSNSSSS 65
            |||||.:| |:|||||||||.||||||||||||||||||||:.||||||||| .|||||.||...
 Frog     1 MAAAKTDM-LVSPLQISDPFSSFPHSPTMDNYPKLEEMMLLNPGAPQFLGAA-VPEGSGFNSPVE 63

Human    66 SSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEKVLVETSYPSQTTRLPP 130
                                       |.:.::||.|::|.|:||:.||.::|:||.:|:.|||.
 Frog    64 ---------------------------GSEQFDHLAADAFSDMSLSGEKAVIESSYANQSARLPS 101

Human   131 ITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAASSASASQSPPLSCAVP 195
            :||||||||||||||.||||||||||||||||.|.|...||:.:.||::||:|:||||||||:|.
 Frog   102 LTYTGRFSLEPAPNSSNTLWPEPLFSLVSGLVGMANASPSSAPSSSPSSSSSSSSQSPPLSCSVQ 166

Human   196 SNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPAAKGGFQVPMIPDYLFPQQ 260
            |||||||||||||||..:.::||:...|.|..::..::.|||||||.:|..||||||||||||||
 Frog   167 SNDSSPIYSAAPTFPNSSPELFPDQSPQPFQNASTASIPYPPPAYPVSKTTFQVPMIPDYLFPQQ 231

Human   261 QGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYP 325
            |||:.|.:.||||||.:|||||||||||||||||||||: |||||.:|::||||:||||||||||
 Frog   232 QGDVSLVSADQKPFQAMESRTQQPSLTPLSTIKAFATQT-SQDLKTINSTYQSQIIKPSRMRKYP 295

Human   326 NRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTH 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   296 NRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTH 360

Human   391 TGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSLSSYPSPVATSYPSPVT 455
            ||||||||||||||||||||||||||||||||||||||:              :||  |..|||
 Frog   361 TGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKA--------------TPV--SVASPV- 408

Human   456 TSYPSPATTSYPSPVPTSFSSPGSSTYPSPVHSGFPSPSVATTYSSVPPAFPAQ-VSSFPSSAVT 519
            :||...|:||||||||||:|||.||.|||||||.||||:.|.||.||...|... ::|||||.||
 Frog   409 SSYSPSASTSYPSPVPTSYSSPVSSAYPSPVHSSFPSPTTAVTYPSVTSTFQTHGITSFPSSIVT 473

Human   520 NSFSA--STGLSDMTATFSPRTIEIC 543
            ||||:  |:.||||:.|:||||||||
 Frog   474 NSFSSPVSSALSDMSITYSPRTIEIC 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EGR1	NP_001955.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		56/103 (54%)
		DUF3446	135..237	CDD:463400	65/101 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..213		32/47 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..284		12/19 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..339		20/20 (100%)
		zf-C2H2	338..362	CDD:395048	23/23 (100%)
		C2H2 Zn finger	340..362	CDD:275368	21/21 (100%)
		zf-H2C2_2	354..379	CDD:463886	24/24 (100%)
		C2H2 Zn finger	370..390	CDD:275368	19/19 (100%)
		zf-H2C2_2	382..407	CDD:463886	24/24 (100%)
		C2H2 Zn finger	398..418	CDD:275368	19/19 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..487		48/77 (62%)
		DUF3432	447..530	CDD:403204	52/85 (61%)
egr1	NP_001090830.1	DUF3446	106..208	CDD:463400	65/101 (64%)
		SFP1	<222..386	CDD:227516	150/164 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..309		20/20 (100%)
		zf-C2H2	308..332	CDD:395048	23/23 (100%)
		C2H2 Zn finger	310..332	CDD:275368	21/21 (100%)
		zf-H2C2_2	324..349	CDD:463886	24/24 (100%)
		C2H2 Zn finger	340..360	CDD:275368	19/19 (100%)
		zf-H2C2_2	352..377	CDD:463886	24/24 (100%)
		C2H2 Zn finger	368..388	CDD:275368	19/19 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..423		34/60 (57%)
		DUF3432	401..486	CDD:403204	54/87 (62%)