Sequence 1: | NP_005219.2 | Gene: | EGFR / 1956 | HGNCID: | 3236 | Length: | 1210 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001188558.1 | Gene: | slpr / 44111 | FlyBaseID: | FBgn0030018 | Length: | 1155 | Species: | Drosophila melanogaster |
Alignment Length: | 509 | Identity: | 128/509 - (25%) |
---|---|---|---|
Similarity: | 204/509 - (40%) | Gaps: | 119/509 - (23%) |
- Green bases have known domain annotations that are detailed below.
Human 709 ETEFKKI---KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 770
Human 771 NPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDN------IGSQYLLNWCVQIAKGMNYLE 829
Human 830 DR---RLVHRDLAARNVLV-----------KTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 880
Human 881 MALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSILEKGERLPQPPICTIDVY 944
Human 945 MIMVKCWMIDADSRPKFRELI-----IEFSKMARDPQ--------------------------RY 978
Human 979 LVIQGDERMHLPSPTDSNFYRALMDEEDMDDVV--------DADEYLIPQQGFFSSPSTSR---- 1031
Human 1032 -----TPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLP--- 1088
Human 1089 -------VPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGN 1135 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
EGFR | NP_005219.2 | Recep_L_domain | 57..168 | CDD:279382 | |
Approximate | 75..300 | ||||
Furin-like | 185..335 | CDD:279142 | |||
FU | 231..274 | CDD:238021 | |||
Recep_L_domain | 361..481 | CDD:279382 | |||
Approximate | 390..600 | ||||
GF_recep_IV | 505..637 | CDD:291509 | |||
FU | 506..559 | CDD:238021 | |||
FU | 552..598 | CDD:214589 | |||
TM_ErbB1 | 634..677 | CDD:213054 | |||
Important for dimerization, phosphorylation and activation | 688..704 | ||||
PTKc_EGFR | 704..1016 | CDD:270683 | 101/369 (27%) | ||
TyrKc | 713..968 | CDD:197581 | 91/283 (32%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1097..1137 | 9/39 (23%) | |||
slpr | NP_001188558.1 | SH3_MLK | 47..104 | CDD:212809 | |
TyrKc | 129..386 | CDD:197581 | 90/276 (33%) | ||
STKc_MLK | 134..389 | CDD:270963 | 90/274 (33%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 0 | 0.000 | Not matched by this tool. | |||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
0 | 0.000 |