DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment EGFR and slpr

DIOPT Version :9

Sequence 1:NP_005219.2 Gene:EGFR / 1956 HGNCID:3236 Length:1210 Species:Homo sapiens
Sequence 2:NP_001188558.1 Gene:slpr / 44111 FlyBaseID:FBgn0030018 Length:1155 Species:Drosophila melanogaster


Alignment Length:509 Identity:128/509 - (25%)
Similarity:204/509 - (40%) Gaps:119/509 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   709 ETEFKKI---KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 770
            |.|:.::   :|:|||.|..|::|.:  :||:|.|.:| .:..|....:....:|.||.:..::.
  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYY--DGEEVAIKIA-HQTGEDDMQRMRDNVLQEAKLFWALK 184

Human   771 NPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDN------IGSQYLLNWCVQIAKGMNYLE 829
            :.::..|.|:||.:.:.|:         ::|.|....|      |....|:||.:|||:|||||.
  Fly   185 HENIAALRGVCLNTKLCLV---------MEYARGGSLNRILAGKIPPDVLVNWAIQIARGMNYLH 240

Human   830 DR---RLVHRDLAARNVLV-----------KTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 880
            :.   .::||||.:.|||:           ||   :||||||||:.: ...:...|.|   ...|
  Fly   241 NEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKT---LKITDFGLAREM-YNTQRMSAAG---TYAW 298

Human   881 MALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSILEKGERLPQPPICTIDVY 944
            |..|.|....|:..||||||||.:|||:| |..||.|. |.|....:......||.|..|.....
  Fly   299 MPPEVISVSTYSKFSDVWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWG 362

Human   945 MIMVKCWMIDADSRPKFRELI-----IEFSKMARDPQ--------------------------RY 978
            .:|..||..|...||.|:|::     |..||....||                          |:
  Fly   363 ALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRF 427

Human   979 LVIQGDERMHLPSPTDSNFYRALMDEEDMDDVV--------DADEYLIPQQGFFSSPSTSR---- 1031
            ..|:.:.|     ..:....|...::.:..:::        :.:..||.::.....|..|:    
  Fly   428 QTIEEELR-----NKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVMLQPVPSKRKHK 487

Human  1032 -----TPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLP--- 1088
                 .||..||.....::..|..|:......|        .:|.....|||:.....|:.|   
  Fly   488 KGKKNKPLQISLPTGFRHTITAVRDKAEQPGSP--------SFSGLRIVALTDGHKGKTWGPSTM 544

Human  1089 -------VPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGN 1135
                   :|..::...|:.||.:..    |:.....||:.|...|..:...|.:
  Fly   545 HQRERSLLPSQLSGGQPEWPAQTST----HSSFSKSAPNLDKKQQQQNQQQVAS 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EGFRNP_005219.2 Recep_L_domain 57..168 CDD:279382
Approximate 75..300
Furin-like 185..335 CDD:279142
FU 231..274 CDD:238021
Recep_L_domain 361..481 CDD:279382
Approximate 390..600
GF_recep_IV 505..637 CDD:291509
FU 506..559 CDD:238021
FU 552..598 CDD:214589
TM_ErbB1 634..677 CDD:213054
Important for dimerization, phosphorylation and activation 688..704
PTKc_EGFR 704..1016 CDD:270683 101/369 (27%)
TyrKc 713..968 CDD:197581 91/283 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1097..1137 9/39 (23%)
slprNP_001188558.1 SH3_MLK 47..104 CDD:212809
TyrKc 129..386 CDD:197581 90/276 (33%)
STKc_MLK 134..389 CDD:270963 90/274 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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