Sequence 1: | NP_005219.2 | Gene: | EGFR / 1956 | HGNCID: | 3236 | Length: | 1210 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_476759.1 | Gene: | Egfr / 37455 | FlyBaseID: | FBgn0003731 | Length: | 1426 | Species: | Drosophila melanogaster |
Alignment Length: | 1383 | Identity: | 507/1383 - (36%) |
---|---|---|---|
Similarity: | 702/1383 - (50%) | Gaps: | 308/1383 - (22%) |
- Green bases have known domain annotations that are detailed below.
Human 2 RPSGTAGAAL-LALLAALCPASRALEEK--------KVCQGTSNKLTQLGTFEDHFLSLQRMFNN 57
Human 58 CEVVLGNLEITYV-QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYY-----ENS 116
Human 117 YALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQ 181
Human 182 NHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCS-GRCRGKSPSDCCHNQCAAGCTGPRE 245
Human 246 SDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRA 310
Human 311 CGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVA 375
Human 376 FRG-----DSFTHTP---PLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQ 432
Human 433 HGQF-SLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGE 496
Human 497 NSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPE 561
Human 562 CLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPA-----------------GVMGENNTL--- 606
Human 607 ------------------------------VWKYAD----------AGH-VCHLCHP-------- 622
Human 623 --------NCTY--------------------------------GCTGPGLEGCPT--------- 638
Human 639 --NGPKIPS-----------------------------------------------IATG--MVG 652
Human 653 ALLLLLVVALGIGLFMRRRHIVRKRTLR--RLLQERELVEPLTPSGEAPNQALLRILKETEFKKI 715
Human 716 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI 780
Human 781 CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV 845
Human 846 KTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTF 910
Human 911 GSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDP 975
Human 976 QRYLVIQGDERMHLPSPTDSNFYRALMDEEDM-----------DDVVDADEYLIPQQGFFSSPST 1029
Human 1030 S-RTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDT-------- 1085
Human 1086 ------FLPVPE--YINQSVPKRP--AGSVQNPVYHNQPLNPAPSRDPHYQD----PHSTAVGNP 1136
Human 1137 EYLNTVQPTCVNSTFDSP 1154 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
EGFR | NP_005219.2 | Recep_L_domain | 57..168 | CDD:279382 | 49/116 (42%) |
Approximate | 75..300 | 109/230 (47%) | |||
Furin-like | 185..335 | CDD:279142 | 78/150 (52%) | ||
FU | 231..274 | CDD:238021 | 24/42 (57%) | ||
Recep_L_domain | 361..481 | CDD:279382 | 53/128 (41%) | ||
Approximate | 390..600 | 77/227 (34%) | |||
GF_recep_IV | 505..637 | CDD:291509 | 53/240 (22%) | ||
FU | 506..559 | CDD:238021 | 13/52 (25%) | ||
FU | 552..598 | CDD:214589 | 22/62 (35%) | ||
TM_ErbB1 | 634..677 | CDD:213054 | 12/102 (12%) | ||
Important for dimerization, phosphorylation and activation | 688..704 | 6/15 (40%) | |||
PTKc_EGFR | 704..1016 | CDD:270683 | 175/322 (54%) | ||
TyrKc | 713..968 | CDD:197581 | 152/254 (60%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1097..1137 | 11/45 (24%) | |||
Egfr | NP_476759.1 | Recep_L_domain | 419..547 | CDD:279382 | 53/127 (42%) |
GF_recep_IV | 572..684 | CDD:291509 | 36/119 (30%) | ||
FU | 573..>606 | CDD:238021 | 10/32 (31%) | ||
FU | 617..659 | CDD:214589 | 22/47 (47%) | ||
FU | 662..716 | CDD:214589 | 3/53 (6%) | ||
FU | 739..786 | CDD:238021 | 5/46 (11%) | ||
FU | 784..834 | CDD:214589 | 10/49 (20%) | ||
PTKc_EGFR_like | 930..1208 | CDD:270648 | 165/277 (60%) | ||
STYKc | 938..1194 | CDD:214568 | 152/255 (60%) | ||
Recep_L_domain | 128..239 | CDD:279382 | 49/116 (42%) | ||
Furin-like | 253..401 | CDD:279142 | 78/153 (51%) | ||
FU | 255..292 | CDD:214589 | 18/37 (49%) | ||
FU | 302..345 | CDD:238021 | 24/42 (57%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 1 | 1.000 | 339 | 1.000 | Domainoid score | I1096 |
eggNOG | 1 | 0.900 | - | - | E1_KOG1025 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 1 | 1.050 | 607 | 1.000 | Inparanoid score | I933 |
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 1 | 1.010 | - | - | QHG45861 | |
OrthoDB | 1 | 1.010 | - | - | D51516at33208 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0000755 | |
OrthoInspector | 1 | 1.000 | - | - | otm40594 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_101159 | |
Panther | 1 | 1.100 | - | - | O | PTHR24416 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R5222 |
SonicParanoid | 1 | 1.000 | - | - | X448 | |
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 1 | 0.960 | - | - | ||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
13 | 12.870 |