DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MEGF6 and NimA

DIOPT Version :9

Sequence 1:	XP_011539187.1	Gene:	MEGF6 / 1953	HGNCID:	3232	Length:	1603	Species:	Homo sapiens
Sequence 2:	NP_001285918.1	Gene:	NimA / 318930	FlyBaseID:	FBgn0261514	Length:	565	Species:	Drosophila melanogaster

Alignment Length:	125	Identity:	53/125 - (42%)
Similarity:	68/125 - (54%)	Gaps:	8/125 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   920 RACDTGHWG------PDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQR 978
            |.|..|:.|      ..|...|....|.||| .:..:|.||.||:|..|.|:|....:|..|:..
  Fly   110 RFCCQGYEGNLSDSQATCKPICRGGCGRGSC-VMPDICSCEEGYIGKHCTQRCDHDRWGLDCKNL 173

Human   979 CQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCL 1038
            ||||:|||||:.||.|.|.|||.|.|||..||.|.:|:.||.||:|.. ..|:...|:|:
  Fly   174 CQCQNGAACDNKSGLCHCIAGWTGQFCELPCPQGTYGIMCRKACDCDE-KPCNPQTGACI 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MEGF6	XP_011539187.1	EMI	108..176	CDD:284877
		vWFA	<215..261	CDD:294047
		FXa_inhibition	268..304	CDD:291342
		vWFA	<342..384	CDD:294047
		FXa_inhibition	397..432	CDD:291342
		vWFA	<432..469	CDD:294047
		vWFA	<472..511	CDD:294047
NimA	NP_001285918.1	EMI	52..116	CDD:284877	2/5 (40%)
NimA	NP_001285918.1	EGF_2	170..200	CDD:285248	18/29 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900