DRSC/TRiP Functional Genomics Resources

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Protein Alignment MEGF6 and Y64G10A.7

DIOPT Version :9

Sequence 1:XP_011539187.1 Gene:MEGF6 / 1953 HGNCID:3232 Length:1603 Species:Homo sapiens
Sequence 2:NP_001255802.1 Gene:Y64G10A.7 / 178377 WormBaseID:WBGene00013416 Length:1714 Species:Caenorhabditis elegans


Alignment Length:1704 Identity:672/1704 - (39%)
Similarity:875/1704 - (51%) Gaps:251/1704 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    84 TSG----DLEVQVSSPVRNGRGSNRCWPHVCAEQELTLVGRRQPCVQALSHTVPVWKAGCG--WQ 142
            |||    |:::|   .:|.|:      .:||..:|:.:|..::|||||.:..|...|.||.  :|
 Worm    16 TSGGELVDVQLQ---ELRLGQ------RNVCPHEEVEIVTLKEPCVQAYTKYVRSRKPGCNGKFQ 71

Human   143 AWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPG--- 204
            : |...:.:|:|:..|::|..|...||..||.||:.:|.|.||..|.|||.||.:||.|||.   
 Worm    72 S-CAVRQPKTIYFHTYKKVNRTRRHTVAECCPGWVHRPGEAGCQRANCSADLCHNGGTCVPSEHN 135

Human   205 -SAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFR-------------- 254
             :.|.|.||.||.|.:||||.:||..:||||:|.||||.|:|.|.|.|||.              
 Worm   136 DNEQVCECPVGFTGAKCQYDANECMANNGGCEHECVNTIGTYYCRCWPGFELSGDGNTCSDIDEC 200

Human   255 ---------------------------LHTDSRTCLAINSCALGNGGCQHHCVQLTITR-HRCQC 291
                                       ||.|.|||..:.||:..||||:|.|...:... :||:|
 Worm   201 AVSNGGCSDRCVNSPGGFRCDCPSDLYLHADGRTCGKVTSCSTDNGGCEHECENDSNGEFYRCRC 265

Human   292 RPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLA 356
            |.||:|.|:.|.|....||.:..|.|.|.|....|.|:|:|:.|:.|:.|.::|.|:||||....
 Worm   266 RVGFKLSENKRSCQPVDPCFDNKGGCQHHCTNNHGRAQCQCYPGFHLSYDRRSCVDIDECAKNNG 330

Human   357 QCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGC-SHTSAGPLCTCP 420
             |.|.|.|.:|:::|.|..||:||.|||.|    .|::..|:..||||.|.| .....|.:|.|.
 Worm   331 -CEHFCENVKGTYRCKCREGYQLGRDGRTC----EEMLGGCQVGNGGCQHDCYDQPDGGHVCKCR 390

Human   421 RGYELDTDQRTCID---------------------------------------------VDD--- 437
            .||.|..||:.|.|                                             .||   
 Worm   391 NGYILANDQKLCHDNISTVIHARAPRLWDSYETVTCVTPTDLTCHKLCMHLDSGHVQCFCDDGYE 455

Human   438 ------CAD-SPC------CQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHC 489
                  |.| :.|      |.|:|.|..|..||.|..|:||..|...|||:.||:|:.||||..|
 Worm   456 LIDSKFCQDINECHENNGDCSQICVNLAGSVECQCKPGFRLMKDRKTCEDISECSSNNGGCEQIC 520

Human   490 TNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRP--------------LPH----- 535
            :|..|.:.||||.|:.|.||...|..:.|.:::..|.....:.              |.|     
 Worm   521 SNQEGGYMCSCEPGFELSEDGHSCHDMNECLINNGGCAQLCKNRKGSRRCQCFAGYILAHDEKSC 585

Human   536 IAV----------LQD--ELPQLFQDDDV-------GADEEEAEL---RGEHTLTEKFVCLDDSF 578
            :|.          ::|  ::|.|...|:|       .|||....|   |..|...    |.:..|
 Worm   586 VAASDSADIFSNDIEDYSKVPGLDSIDEVISSIESYPADESPRPLVFGRRRHVKE----CPNGFF 646

Human   579 GHDCSLTCDDCRNGGTCLLG----LDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCD 639
            |..|.|:|.||:|||.|.:.    |..||||.|:||..|.:.|....:|.:|:..|||:   .||
 Worm   647 GSTCQLSCSDCQNGGKCSMRGSGLLSKCDCPSGYTGEKCEQICRNGYWGVDCAHKCSCK---LCD 708

Human   640 SVTGACRCPPGVSGTNCEDG-CPKGYYGKHCRKKC--NCANRGRCHRLYGACLCDPGLYGRFCHL 701
            ..||:|||.   ....|.|| ||.|:||..|..||  :|.| |||..::|.|.|..||||:.|..
 Worm   709 PSTGSCRCE---DPEKCSDGPCPDGFYGSQCNLKCRMDCPN-GRCDPVFGYCTCPDGLYGQSCEK 769

Human   702 TCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVG 766
            .||.:.||..|...|:|.:.:::.||:..|.|.||.|:.|..|:..|..|.||.||...|:||.|
 Worm   770 PCPHFTFGKNCRFPCKCARENSEGCDEITGKCRCKPGYYGHHCKRMCSPGLFGAGCAMKCSCPAG 834

Human   767 VACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCG--GAP-----CHGVTGQCRCPP 824
            :.||.|:|:|.|:||||:||..|.|.||.|.||.:|...|||.  .:|     ||.|||.|.|.|
 Worm   835 IRCDPVTGDCTKKCPAGYQGNLCDQPCPAGYFGYDCEQKCSCADVASPHKSKVCHHVTGTCTCLP 899

Human   825 GRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQ 889
            |:||..|:..|....:|..|...| :|.:.|:||...|:|.|.|||.|:.|.:|||.|.:|..|.
 Worm   900 GKTGPLCDQSCAPNTYGPNCAHTC-SCVNGAKCDESDGSCHCTPGFYGATCSEVCPTGRFGIDCM 963

Human   890 TRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCS---------------- 938
            ..|.|.|...|..:.|.|.|||||:|..|.:||..|.:|.|||..|:|:                
 Worm   964 QLCKCQNGAICDTSNGSCECAPGWSGKKCDKACAPGTFGKDCSKKCDCADGMHCDPSDGECICPP 1028

Human   939 --AGH------------------------GSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQ 977
              .||                        .:||:::|.|.|..|:.|.:|::.||.|.||.||..
 Worm  1029 GKKGHKCDETCDSGLFGAGCKGICSCQNGATCDSVTGSCECRPGWRGKKCDRPCPDGRFGEGCNA 1093

Human   978 RCQC----------QHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDA 1032
            .|.|          ...|.||||:|.|.|||||.|..|:.:||.|..|..||.:|.|:.||:||.
 Worm  1094 ICDCTTTNDTSMYNPFVARCDHVTGECRCPAGWTGPDCQTSCPLGRHGEGCRHSCQCSNGASCDR 1158

Human  1033 VNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACPA 1097
            |.|.|.||:|..|..|...||...:|.||.:.|.|.:|..|:..:|.|.|..||.||||...||.
 Worm  1159 VTGFCDCPSGFMGKNCESECPEGLWGSNCMKHCLCMHGGECNKENGDCECIDGWTGPSCEFLCPF 1223

Human  1098 GLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPH 1162
            |.:|.||...|.|:||.:||..:|.|.|..||:|..|||.|:.....|.|..:..|.||.||||.
 Worm  1224 GQFGRNCAQRCNCKNGASCDRKTGRCECLPGWSGEHCEKSCVSGHYGAKCEETCECENGALCDPI 1288

Human  1163 TGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPG 1227
            :|.|.|..||.|.||..|||:|:||..|:|.|.|....:|.|::|.|:||.|:.|..|.:.||.|
 Worm  1289 SGHCSCQPGWRGKKCNRPCLKGYFGRHCSQSCRCANSKSCDHISGRCQCPKGYAGHSCTELCPDG 1353

Human  1228 SFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAA 1292
            :|||.|:|.|.| |||..|...:|.|.|..|:.|..|:..|..||:||.|.|||.|.|||.||::
 Worm  1354 TFGESCSQKCDC-GENSMCDAISGKCFCKPGHSGSDCKSGCVQGRFGPDCNQLCSCENGGVCDSS 1417

Human  1293 TGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQN 1357
            ||:|.||.|::||.|.:.|...||||.|..:|.|..|..||.:||.|.|.||..|:.|.:.||:.
 Worm  1418 TGSCVCPPGYIGTKCEIACQSDRFGPTCEKICNCENGGTCDRLTGQCRCLPGFTGMTCNQVCPEG 1482

Human  1358 RFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPAT 1422
            |||.||:..|.|.||. |:||:|.|.|.||:||..||.:||.|:||..|.|:|.|:..:.|:|..
 Worm  1483 RFGAGCKEKCRCANGH-CNASSGECKCNLGFTGPSCEQSCPSGKYGLNCTLDCECYGQARCDPVQ 1546

Human  1423 GTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGS 1487
            |.|.|.||.||..|:..||.||:|..|...|.||:||.||...|||||||||.|..||:.|..||
 Worm  1547 GCCDCPPGRYGSRCQFSCPNGFYGWYCSQSCSCQNGAHCDGADGRCLCPAGFQGDKCEQKCSEGS 1611

Human  1488 FGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSG 1552
            ||..|.|:|:| |...||...|.|:||.||.|..|..:||.|::|.||...|.|..||.||..:|
 Worm  1612 FGPACSQQCNC-GKYKCDATDGKCICPVGRHGPLCEEECRPGRYGQSCQNKCQCFNGATCDARTG 1675

Human  1553 QCHCVDGYMGPTCR 1566
            ||.|..|::||||:
 Worm  1676 QCSCSPGWLGPTCQ 1689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MEGF6XP_011539187.1 EMI 108..176 CDD:284877 24/69 (35%)
vWFA <215..261 CDD:294047 27/86 (31%)
FXa_inhibition 268..304 CDD:291342 16/36 (44%)
vWFA <342..384 CDD:294047 18/41 (44%)
FXa_inhibition 397..432 CDD:291342 15/35 (43%)
vWFA <432..469 CDD:294047 18/97 (19%)
vWFA <472..511 CDD:294047 21/38 (55%)
Y64G10A.7NP_001255802.1 EMI 35..105 CDD:284877 25/70 (36%)
FXa_inhibition 159..194 CDD:291342 17/34 (50%)
FXa_inhibition 200..235 CDD:291342 4/34 (12%)
FXa_inhibition 241..278 CDD:291342 16/36 (44%)
vWFA <319..358 CDD:294047 19/39 (49%)
FXa_inhibition 366..402 CDD:291342 15/35 (43%)
vWFA <460..502 CDD:294047 15/41 (37%)
FXa_inhibition 509..544 CDD:291342 17/34 (50%)
FXa_inhibition 550..585 CDD:291342 3/34 (9%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 117 1.000 Domainoid score I4070
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H45412
Inparanoid 1 1.050 1318 1.000 Inparanoid score I68
Isobase 1 0.950 - 0 Normalized mean entropy S4920
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D18200at33208
OrthoFinder 1 1.000 - - FOG0001719
OrthoInspector 1 1.000 - - oto22702
orthoMCL 1 0.900 - - OOG6_108366
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3152
SonicParanoid 1 1.000 - - X5119
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.850

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