DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CELSR2 and fmi-1

DIOPT Version :9

Sequence 1:	NP_001399.1	Gene:	CELSR2 / 1952	HGNCID:	3231	Length:	2923	Species:	Homo sapiens
Sequence 2:	NP_506256.3	Gene:	fmi-1 / 179788	WormBaseID:	WBGene00001475	Length:	2596	Species:	Caenorhabditis elegans

Alignment Length:	2778	Identity:	790/2778 - (28%)
Similarity:	1229/2778 - (44%)	Gaps:	354/2778 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    51 CAPMGWLCPSSASNLWLYTSR--CRDAGTELTGHLVPHHDGLRVWCPESEAHIPLPPAPEGCPWS 113
            |.|..  .|||.|.:||..||  |...|..:. |.....|.|.  |       |:|..|:....|
Worm    39 CKPCA--VPSSNSVIWLPASRPPCLHPGQPII-HWPDLSDNLA--C-------PVPGLPDSVHSS 91

Human   114 CRLLGIGGHLSPQGKLTLPEEHPCLKAPRLR------CQSCKLAQAPGLRAGER-SPEESLGGR- 170
            ...|     |..:| |.|.:|..|.....:.      |.. ||.::. :|.|.. :.::.|..|
Worm    92 QISL-----LEGEG-LLLTKERICFFDGPIDFHYDYVCDG-KLYRSK-MRIGHSIASKKKLETRR 148

Human   171 -----RKRNVN-TAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSN 229
                 |:||.: .|..||...|...:||:.|..|.:||::|   ....:..|.|:|.|..||||.
Worm   149 TKRWARRRNPDANAVHFQQEKYVKELPEDTPIETIIASVKA---SHASSQPLYYSMVAPQDSRSQ 210

Human   230 QFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEY 294
            ..|:||.::|.:..|:.:|||....|:.:|||.:...|..||..|:.:.|.|..|:.|:||:..|
Worm   211 NLFTLDTMSGEIRLAKSMDREVLDKHILKVTAYERVDPTISASTTVVVHVLDVQDNSPIFEKDSY 275

Human   295 KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREE 359
            ...:||:..:|..||:|.|.|.|:..|..|.|.|.||:|   ..:..|:.:||||:|..|:|||.
Worm   276 FGEIREDAPIGTTVLSVFARDLDSGENGEIEYSLGEGNG---KNLLAINAKSGVIQTAAPLDRET 337

Human   360 VESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTAS 424
            :...:|.|.|||:|..  .|.:||.|.::|.|.|||||.|:...|.|.:.|::|..|.:..|.|:
Worm   338 LSLIRLDVIASDKGTP--KRESTAMVEITVVDVNDNAPVFASDSYNVTILENITIPAVIATVKAT 400

Human   425 DRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSG 489
            |.|.|:|..||||:.|.:..|...:|..||.:.:...:|.:.: ..|..:||:||.:|.||:...
Worm   401 DEDFGTNGKVHYSMASSSGIGGLTIDYSTGEVTLRERIDAKNS-PITAVIRAKDGAQPALSSTVP 464

Human   490 LVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFT 554
            | |:.|:||||:||..::.....|:.|:|.:|..|..|.|||.|:|.|..::|.:.| ..|  |.
Worm   465 L-TINVIDINDHAPTLIAAQKMITLEENVAIGEEVGRVYAIDEDSGPNGIIKYSMEG-SED--FI 525

Human   555 INNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRL 619
            |:..:|.|.....||||....||..|.|||.|||:|..|.:::|.:.|:|||.|||.:.||.|.:
Worm   526 IDEDSGLIKTTKLLDRETTARYSLKVTARDMGTPSLNTSTTIAVVLKDINDNAPTFDKKEYNVTI 590

Human   620 NEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQ---Y 681
            :|:...|:.::|:.|||.|....|||:|...: |..|||......|.:   |.:..:|:||   .
Worm   591 SEEMPRGSQIITLKAVDNDEDQKITYRIEEAD-REVFSILDIGDQGAI---LSVSGELKRQDHKV 651

Human   682 VLAVTASD-GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENA 745
            .:.::|:| |..|....:.|.:.|.|: .|.|....::|.:.|..|.|..|:.:.|.|.|.|:||
Worm   652 RVEISATDQGGLQGRCVVNVFIDDVNS-APYFNDHPFSVKIPEHSPIGYPVITLKAEDHDRGDNA 715

Human   746 RITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVND 810
            ||.|.: ||...||||..:|.::..::||.||:.::::.:||.|:..|..:.:|.:|::::|:||
Worm   716 RIVYSI-DSSQFFRIDPSSGDISVSSDLDREDRATFSVIVTASDHASPPLNTSTQIEVILDDIND 779

Human   811 NAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGD--FIVESTSGIV 873
            |:|||...||..::.||:|..||.||:||.|.|.|.||.|.|...........  |.::.|||.:
Worm   780 NSPQFTSSSYAATISEDIPVGTSFLQVSAIDADIGPNGIVDYFLNESSSSPSIQLFRLDRTSGTL 844

Human   874 RTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGL 938
            |...:||||..|..||..:|.|:|.|......|:|:|:.|||||.|.|||..:|:::.||||:|.
Worm   845 RVSSKLDREQFAVIVLPIFARDRGTPSLSAASEITLTLSDVNDNAPTFEQLSYDLYIAENSPVGS 909

Human   939 AVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALV------DLDYEDRP-EYVLVI 996
            .|..:.|.|.|||.||.|.::|..|...::|.:: ...|...:|      :.|||.:. ::...:
Worm   910 TVGTIVARDADEGDNADISFRIFGGADAKLFDIE-EDAEQNGVVRILTRAEFDYEAKANKFFFEL 973

Human   997 QATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLT 1061
            ||:|..|.|...|.:.:.|.|||.|.|.:|.||.|.:...:.:.    .||.:||.|||.:.:|.
Worm   974 QASSGQLSSTVPVRIHVSDVNDNKPALKDFVILMNRFDNVQMAR----QIGFIPAFDPDQNATLE 1034

Human  1062 YSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLT 1126
            |..|   |..|:.....||::.:.:....|  ::......||||.::..:.|.....::..|.|:
Worm  1035 YFLE---ENDLIEAEKYTGKILVKQEWKRN--MDVSFKTCVSDGANTECSTCRFIHVLVEPEWLS 1094

Human  1127 HSITLRLEDMSPERFLSPLLGLFIQAVAATLAT-PPDHVVVFNVQRDTDAPGGHILNVSLSVGQP 1190
            .|.||.|..|:.:.|..||:....:...:||:. .|..:.|..|::..|  ....:|::::....
Worm  1095 ESFTLSLARMTVDDFWDPLVFQRFRDAMSTLSNWKPSDIHVIGVKQHLD--DVIYINIAITDHGR 1157

Human  1191 PGPGGGPPFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPF 1255
            ...|.....|..|.:::   |.:..|..:...|     |..|..|||.:..:|....:|......
Worm  1158 VVRGWRAIELVKESIKK---LEKMTLLQVEVIR-----DESCANEPCSHMAKCRQTQKFVGEMKA 1214

Human  1256 IASSSVLFRPIHPVGGLRCRCPPGFT-----GDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCR 1315
            ..:.:.:.|.::.|....|.||.|||     || |:|.:|.||...|..:..|.:.|..|.|.|:
Worm  1215 HETDNFIARTLNTVNTFVCECPSGFTSSGAHGD-CDTRIDECYRGRCSNNSTCVAFENTYQCECK 1278

Human  1316 DGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKC-DCP-SGDFEKPYCQVTTRSFPAHSFI 1378
            .|:.|.|||:|..:..|.||.|.:...| .|.....|| .|. .|:.....|::.:.||.....:
Worm  1279 PGWIGRHCEISVHALTCVPGYCMSDSLC-ELDGNQMKCRHCKYHGEDTDERCRLRSVSFDGEGLL 1342

Human  1379 TFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAG--ESTTTVSP 1441
            .......|..:|:....:|...:|:|::.|  :::.|||.:.|:...:::.||.|  :....:..
Worm  1343 NVNLDLPRTQWTMKFRVSTIAHNGVLVFTG--DKRSDFVEVSVVDRVLKVQFSLGGEKIDAKMEN 1405

Human  1442 FVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAA 1506
            .|...::||:||||.|:|.||.:                .:::|.|:|..:|...:   :.:||.
Worm  1406 DVENRINDGEWHTVALEYSNKQI----------------TMSLDDCETNPSLLLNT---SPNCAI 1451

Human  1507 QGTQGGSKKS----------LDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADF 1561
            :......||.          ||::..|.|||.|...:...   :.|.||:.:|.||...:|.:..
Worm  1452 RAKLNLEKKCEDPTVPCYRYLDISNGLFLGGRPGTSKQIE---KAFSGCISDLSVDKEDVDFSTI 1513

Human  1562 --IANNGTV-PGCPAKKNVCDSN--TCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLG 1621
              :...|.| .||..:|:.|.::  .|.....|||:|....|.||...............|...|
Worm  1514 KEMHKVGQVHEGCKHRKDFCSTSDGQCSATSKCVNRWGGRICSCPQSVHSTGECVGALGTQDLRG 1578

Human  1622 SSLVAWHGLSL----PISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSV-EGT- 1680
            .||.......|    .:|.|:.:|..|||.:||   :|..     .:....|..|..|.| :||
Worm  1579 HSLFEEESFVLYQPSQVSVPFEVSFEFRTSRAD---MQVF-----ALEFTQRSVHYNLEVDDGTL 1635

Human  1681 --GLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNIT 1743
              .:..|.:.|.........|.:..:...|.     ::.:...|...||....  :..::|.::.
Worm  1636 KYNIGDSEVELPAPEVTSKHWMNVVIKFEAD-----SVATSINGIYSAEAKAS--ISDMNLESLY 1693

Human  1744 VGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQ------GCSLPDPCD-SNP 1801
            .|..|| .|..:| |.||::.|.|.             |.||:|::      ||.:|:.|. .:.
Worm  1694 FGIAPG-TGHPSR-FEGCIRNVLVD-------------GRSISVKKKGKTRAGCVVPNRCSVDSI 1743

Human  1802 CPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDL-NPCEHQSVCTRKPSAPHGYTCECPPNYLGPY 1865
            |||.|.|...|:.:.|.|...:.||.|..||.: |.|...:..:...:|  ||.|.||....|..
Worm  1744 CPAESTCHRAWNKHKCKCHKSFVGDTCLPVCSVANVCSSGTCVSSNTTA--GYECICPAGKTGKN 1806

Human  1866 CETRI-DQPCPRGWWG-HPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYP 1928
            |:... .|.||.|||| .|.|..|:|..:|.::..|:|.:|.|.||::|:.....  |:.|:| .
Worm  1807 CQLEAPKQMCPSGWWGTFPRCRRCSCAQTKDYEAQCDKKTGACQCKKSHFSTING--CVKCEC-G 1868

Human  1929 TGSLSRVCDPEDGQCPCKPGVIGRQCDRC---DNPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTR 1990
            .|:.|..|. .||.|.|....:||:||||   |:.....|.. |......||..||..|.||.::
Worm  1869 FGADSTECS-ADGHCKCNGDAVGRRCDRCSRFDHQLDSKTLK-CRPVSGKCPSEIEYSIQWPASQ 1931

Human  1991 FGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQL 2055
            .|......||.|..|.|.|.|.|...|...|.:|||...:|.:....|.|:          ..:|
Worm  1932 KGSIVRQSCPVGESGLATRKCLETGRWSDVNAWNCTRPEYSIMVNKFEILE----------PSKL 1986

Human  2056 ALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLR-VGSALLDTA 2119
            ..::.|||...:...|.:.::|.:..:||:.:|.:....|.:..:|:.|||.|:. :|..:.:..
Worm  1987 LTMVANATNTESSIRGRNQQIAAEALSRLVDYEQSMPMKGRAHIKDMKFTEKLIESLGRVMSEQP 2051

Human  2120 NKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNFAGAKL 2184
            ...:..||.:        |.:|....:.:.:|:  .:||||.:...:||.:..:||.||.    |
Worm  2052 ADEYSTLISK--------LWNYAETVAEIHENV--NFLSPFFVANDHIVFASDKLDFGNI----L 2102

Human  2185 PRYEALRGEQPPDLETTVILPESVFRETPPVVRPAGPGEAQEPEELARRQRRHPELSQGEAVASV 2249
            |::...     .||..|..          |.||....|..|                   .|.|:
Worm  2103 PKFNNF-----VDLRPTGF----------PRVRAIVTGTTQ-------------------VVYSI 2133

Human  2250 IIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVVSISVHDDEELLPRALDKPVTVQFRLLETEER 2314
            :.|                    |:......|:::|..:..:         ||.|:|.:.|.:..
Worm  2134 VPY--------------------PRCNRCENPMIAIVANTSD---------PVIVEFEIEEDDGW 2169

Human  2315 TKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTL 2379
            ..|.||.::..   |||  |:|||..::..|.:|.:|:.|.:..|.:.::........:..:..:
Worm  2170 KYPECVRFDEK---SGT--WTARGAALIGLNLTHAACEYNRIGVFTMFVNDQSSSIVRVAQMDNM 2229

Human  2380 TYVAL-GVTLAALLLTFFFLTLLRILRS-NQHGIRRN--LTAALGLAQLVFL--LGINQADLPFA 2438
            |..|: ||   ||.|.|..:.|....|| ..|.:|..  |..|:.:..|.|:  ..||||    .
Worm  2230 TSPAIAGV---ALFLCFLSILLTLSRRSLKTHSVRIGFILFFAINILNLFFVHKTAINQA----Y 2287

Human  2439 CTVIAILLHFLYLCTFSWALLEALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVG---- 2499
            |.|...:|.|.....|:|..|..|::||.|.:               |...|:..|.|.||
Worm  2288 CPVRNAMLSFTSSAPFAWLFLYGLYIYRMLAD---------------GSSSPSLTTSLLVGIVFP 2337

Human  2500 --LDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGL 2562
              :....:...|.|.||.:..|.|....|:...:.:|.:....:...|...:...|..|..|...
Worm  2338 CLISFTTFFVTDQCSLSPHLWLFWCIILPIGLFLLLSFYAAATSVLVSLHKKYDVFVAKYNVKRA 2402

Human  2563 QPSFAVLLLLSATWLLALLSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALKLACSRK 2627
            .....:|.:.:....|..|..|...|....:..:.:.|   ::..:.|:....|......|....
Worm  2403 VFQHFILTIFTLGMTLTGLFANQLPLPMEIMEISQSII---YLIAALVIFLWCVCDITTKASDSN 2464

Human  2628 PS----PDPALTTKSTLTSSYNCPSPYADGR----------LYQPYGDSAGSLHSTSRSGKSQP- 2677
            ||    ...::..:||:... .|.||....|          .:.|..:.:...| ||.:....|
Worm  2465 PSMWLDNQKSVMAESTMADP-QCASPLLSPRHQHHEVPMDSEWVPDVNPSNHYH-TSINEPDTPR 2527

Human  2678 --------SYIPFLLREESALNPGQGPPGLGDPGSL--FLEGQDQQHD 2715
                    ..|..|...:..||.|.|.....:.|||  ....||:..|
Worm  2528 RLLLPQNRDVINILSSPDQILNEGVGHVYRNNMGSLPRLRSAQDEADD 2575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CELSR2	NP_001399.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..198		14/51 (27%)
		Cadherin_repeat	185..285	CDD:206637	34/99 (34%)
		Cadherin_repeat	293..395	CDD:206637	40/101 (40%)
		Cadherin_repeat	404..501	CDD:206637	35/96 (36%)
		Cadherin_repeat	509..606	CDD:206637	37/96 (39%)
		Cadherin_repeat	614..708	CDD:206637	30/97 (31%)
		Cadherin_repeat	716..811	CDD:206637	33/94 (35%)
		Cadherin_repeat	819..917	CDD:206637	40/99 (40%)
		Cadherin_repeat	925..1019	CDD:206637	31/100 (31%)
		Cadherin_repeat	1042..1120	CDD:206637	20/77 (26%)
		EGF_CA	1289..1324	CDD:238011	12/34 (35%)
		EGF_CA	1333..1366	CDD:238011	9/34 (26%)
		LamG	1369..1552	CDD:238058	45/194 (23%)
		EGF_CA	1578..1609	CDD:238011	9/32 (28%)
		LamG	1618..1767	CDD:238058	36/156 (23%)
		EGF_CA	1795..1829	CDD:238011	11/34 (32%)
		EGF	1832..1865	CDD:278437	10/33 (30%)
		EGF_Lam	1924..1969	CDD:214543	17/47 (36%)
		HormR	1972..2034	CDD:214468	22/61 (36%)
		GAIN	2052..2287	CDD:293098	47/235 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2213..2238		5/24 (21%)
		GPS	2315..2368	CDD:197639	15/52 (29%)
		7tm_4	2402..2605	CDD:304433	47/213 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2688..2838		10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2854..2888
fmi-1	NP_506256.3	Cadherin_repeat	170..266	CDD:206637	34/98 (35%)
		Cadherin_repeat	274..371	CDD:206637	40/101 (40%)
		Cadherin_repeat	379..475	CDD:206637	35/97 (36%)
		Cadherin_repeat	486..577	CDD:206637	37/93 (40%)
		Cadherin_repeat	686..780	CDD:206637	33/94 (35%)
		Cadherin_repeat	788..888	CDD:206637	40/99 (40%)
		Cadherin_repeat	896..996	CDD:206637	31/100 (31%)
		EGF_CA	1252..1287	CDD:238011	12/34 (35%)
		LamG	1333..1504	CDD:238058	45/194 (23%)
		LamG	1582..1716	CDD:238058	33/150 (22%)
		EGF_CA	1774..1808	CDD:238011	10/35 (29%)
		EGF_Lam	1865..1911	CDD:238012	17/48 (35%)
		HormR	1917..1974	CDD:214468	22/56 (39%)
		GPS	2170..2218	CDD:197639	15/52 (29%)
		7tm_GPCRs	2237..2455	CDD:421689	55/242 (23%)
		TM helix 2	2258..2284	CDD:410628	6/25 (24%)
		TM helix 3	2289..2315	CDD:410628	7/25 (28%)
		TM helix 4	2326..2346	CDD:410628	4/19 (21%)
		TM helix 5	2356..2383	CDD:410628	4/26 (15%)
		TM helix 6	2400..2435	CDD:410628	5/34 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161463576
Domainoid	1	1.000	94	1.000	Domainoid score	I5169
eggNOG	1	0.900	-	-		E2759_KOG4289
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	926	1.000	Inparanoid score	I183
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48446
OrthoDB	1	1.010	-	-		D16905at33208
OrthoFinder	1	1.000	-	-		FOG0001609
OrthoInspector	1	1.000	-	-		otm15547
orthoMCL	1	0.900	-	-		OOG6_103211
Panther	1	1.100	-	-	O	PTHR24026
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3194
SonicParanoid	1	1.000	-	-		X912
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840