DRSC/TRiP Functional Genomics Resources

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Protein Alignment CELSR3 and fmi-1

DIOPT Version :9

Sequence 1:NP_001398.2 Gene:CELSR3 / 1951 HGNCID:3230 Length:3312 Species:Homo sapiens
Sequence 2:NP_506256.3 Gene:fmi-1 / 179788 WormBaseID:WBGene00001475 Length:2596 Species:Caenorhabditis elegans


Alignment Length:2692 Identity:754/2692 - (28%)
Similarity:1200/2692 - (44%) Gaps:384/2692 - (14%)


- Green bases have known domain annotations that are detailed below.


Human   304 ARKVTSANRARFRRAANRHP-----QFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYS 363
            |.|.....|...|.|..|:|     .|.|..|...:||:....|.:..|.|..   ..:..|.||
 Worm   139 ASKKKLETRRTKRWARRRNPDANAVHFQQEKYVKELPEDTPIETIIASVKASH---ASSQPLYYS 200

Human   364 LAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRND 428
            :.|..:|||..||::|..||.||.|.::|||.:::|.|:|||.:...|.:||:|.|.|.|.|..|
 Worm   201 MVAPQDSRSQNLFTLDTMSGEIRLAKSMDREVLDKHILKVTAYERVDPTISASTTVVVHVLDVQD 265

Human   429 HSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSG 493
            :||:||:..|...:||:...|..:|.:.|.|.|:..|..:.|. :|....:...|    |:.:||
 Worm   266 NSPIFEKDSYFGEIREDAPIGTTVLSVFARDLDSGENGEIEYS-LGEGNGKNLLA----INAKSG 325

Human   494 LISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDV 558
            :|.|:..:|||.:....|.|.|||:|..  .|.:|..|.|||:|.|||||.|:...|...:.|::
 Worm   326 VIQTAAPLDRETLSLIRLDVIASDKGTP--KRESTAMVEITVVDVNDNAPVFASDSYNVTILENI 388

Human   559 RPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQ 623
            ....|:..|.|||.|...||.|||::.|.:..|...||..|||:.:...:|.:.....|: |||:
 Worm   389 TIPAVIATVKATDEDFGTNGKVHYSMASSSGIGGLTIDYSTGEVTLRERIDAKNSPITAV-IRAK 452

Human   624 DAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEY 688
            |..:|.||:...| :|.|:|||||.|..::....:::.||..:|..|..:.|:|.|.|.|..::|
 Worm   453 DGAQPALSSTVPL-TINVIDINDHAPTLIAAQKMITLEENVAIGEEVGRVYAIDEDSGPNGIIKY 516

Human   689 SLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 753
            |:.|   ...|:|:..:|.:..:..||||:...|...|.|||.|:|.|:.|.::.|.:.|:|||.
 Worm   517 SMEG---SEDFIIDEDSGLIKTTKLLDRETTARYSLKVTARDMGTPSLNTSTTIAVVLKDINDNA 578

Human   754 PEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALP 818
            |.|..|||::.::|:...|:.::::.|||.|.:..|:|:|...: |..|:|...|..|.: |::.
 Worm   579 PTFDKKEYNVTISEEMPRGSQIITLKAVDNDEDQKITYRIEEAD-REVFSILDIGDQGAI-LSVS 641

Human   819 LDYK-QERYFKLVLTASDR-ALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVIS 881
            .:.| |:...::.::|:|: .|...|.|::.|.|.|: .|.|....:||.:.|..|:|..::.:.
 Worm   642 GELKRQDHKVRVEISATDQGGLQGRCVVNVFIDDVNS-APYFNDHPFSVKIPEHSPIGYPVITLK 705

Human   882 ASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTY 946
            |.|.|.|:||||.|.: |:...||||..||.|::.:.||.||:.|:::.:||.|:..|....:|.
 Worm   706 AEDHDRGDNARIVYSI-DSSQFFRIDPSSGDISVSSDLDREDRATFSVIVTASDHASPPLNTSTQ 769

Human   947 VEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGD-- 1009
            :||:::|:|||:|||.:|.|...:|||.|..||.||:||.|.|...||.|.| |.|.......  
 Worm   770 IEVILDDINDNSPQFTSSSYAATISEDIPVGTSFLQVSAIDADIGPNGIVDY-FLNESSSSPSIQ 833

Human  1010 -FTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFE 1073
             |.::.|||.:|...:||||..:|..|..:|.|||.|.|.....|.:.:.|||||||.|....::
 Worm   834 LFRLDRTSGTLRVSSKLDREQFAVIVLPIFARDRGTPSLSAASEITLTLSDVNDNAPTFEQLSYD 898

Human  1074 VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALI------DLDY 1132
            :.:.|||.|||.|..|.|.|.|||.||.|.::|..|...:||.:: ...|...::      :.||
 Worm   899 LYIAENSPVGSTVGTIVARDADEGDNADISFRIFGGADAKLFDIE-EDAEQNGVVRILTRAEFDY 962

Human  1133 EAR-QEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIP 1196
            ||: .::...:||:|..|.|...|.:.:.|.|||.|.|.:|.||.|.:    .:...:..||.||
 Worm   963 EAKANKFFFELQASSGQLSSTVPVRIHVSDVNDNKPALKDFVILMNRF----DNVQMARQIGFIP 1023

Human  1197 AYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVL 1261
            |:|||.:..|.|..|   |..|:...:.:|::.:.::...|  :..|....|:||.::..:.|..
 Worm  1024 AFDPDQNATLEYFLE---ENDLIEAEKYTGKILVKQEWKRN--MDVSFKTCVSDGANTECSTCRF 1083

Human  1262 RVVIITEELLANSLTVRLENMWQERFLSPLL-GRFLEGVAAVLATPAEDVFIFNIQNDTDVGGTV 1325
            ..|::..|.|:.|.|:.|..|..:.|..||: .||.:.::.:......|:.:..::...|     
 Worm  1084 IHVLVEPEWLSESFTLSLARMTVDDFWDPLVFQRFRDAMSTLSNWKPSDIHVIGVKQHLD----- 1143

Human  1326 LNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCLREPCENYMKC 1390
             :|.:..:|....|....| |.:.|.::|.:    ..|...:||.|....|..|..|||.:..||
 Worm  1144 -DVIYINIAITDHGRVVRG-WRAIELVKESI----KKLEKMTLLQVEVIRDESCANEPCSHMAKC 1202

Human  1391 VSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFT-----GDFCETELDLCYSNPCRNGGAC 1450
            ....:|........:.:.:.|.:..:....|.||.|||     || |:|.:|.||...|.|...|
 Worm  1203 RQTQKFVGEMKAHETDNFIARTLNTVNTFVCECPSGFTSSGAHGD-CDTRIDECYRGRCSNNSTC 1266

Human  1451 ARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRCQ-CPAGGAFEGPRCE 1514
            ...|..|.|.|:|.:.|..||:...|..||||.|.:...| :......:|: |...|.....||.
 Worm  1267 VAFENTYQCECKPGWIGRHCEISVHALTCVPGYCMSDSLC-ELDGNQMKCRHCKYHGEDTDERCR 1330

Human  1515 VAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYS 1579
            :.:.||.....:.......|...|:....:|:..:|:|.:.|  :::.||:.:.:|...:::.:|
 Worm  1331 LRSVSFDGEGLLNVNLDLPRTQWTMKFRVSTIAHNGVLVFTG--DKRSDFVEVSVVDRVLKVQFS 1393

Human  1580 TG--ESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQ 1642
            .|  :.:..:...|...::||:||||.|.|.||..|                :|:|||:...:|.
 Worm  1394 LGGEKIDAKMENDVENRINDGEWHTVALEYSNKQIT----------------MSLDDCETNPSLL 1442

Human  1643 FGAEIGNYSCAAAGVQTSSKKS----------LDLTGPLLLGGVPNLPENFPVSHKDFIGCMRDL 1697
            ...   :.:||........||.          ||::..|.|||.|...:..   .|.|.||:.||
 Worm  1443 LNT---SPNCAIRAKLNLEKKCEDPTVPCYRYLDISNGLFLGGRPGTSKQI---EKAFSGCISDL 1501

Human  1698 HIDGRRVDMAAF--VANNGTM-AGCQAKLHFCDS--GPCKNSGFCSERWGSFSCDCP-------- 1749
            .:|...||.:..  :...|.: .||:.:..||.:  |.|..:..|..|||...|.||        
 Worm  1502 SVDKEDVDFSTIKEMHKVGQVHEGCKHRKDFCSTSDGQCSATSKCVNRWGGRICSCPQSVHSTGE 1566

Human  1750 -VG-FGGKDCQLTMAHPHHFRGNGTL---SWNFGSDMAVSVPWYLGLAFRT-RATQGV--LMQVQ 1806
             || .|.:|          .||:...   |:.......||||:.:...||| ||...|  |...|
 Worm  1567 CVGALGTQD----------LRGHSLFEEESFVLYQPSQVSVPFEVSFEFRTSRADMQVFALEFTQ 1621

Human  1807 AGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVS 1871
            ...|..|  ::|.|.|...:  |.   |.:.|....|:...|.::.::.:.:          .|:
 Worm  1622 RSVHYNL--EVDDGTLKYNI--GD---SEVELPAPEVTSKHWMNVVIKFEAD----------SVA 1669

Human  1872 LDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQGVWLGSTPSGSPALLPPSH 1936
            ...:......|..| :..:.::.|:. |:.||:..  |....|||:.|.:    .|....:....
 Worm  1670 TSINGIYSAEAKAS-ISDMNLESLYF-GIAPGTGH--PSRFEGCIRNVLV----DGRSISVKKKG 1726

Human  1937 RVNAEPGCVVTNACA-SGPCPPHADCRDLWQTFSCTCQPGYYGPGCVDAC-LLNPCQNQGSCRHL 1999
            :..|  ||||.|.|: ...||..:.|...|....|.|...:.|..|:..| :.|.| :.|:|.. 
 Worm  1727 KTRA--GCVVPNRCSVDSICPAESTCHRAWNKHKCKCHKSFVGDTCLPVCSVANVC-SSGTCVS- 1787

Human  2000 PGAPHGYTCDCVGGYFGHHCE-HRMDQQCPRGWWGS-PTCGPCNCDVHKGFDPNCNKTNGQCHCK 2062
            .....||.|.|..|..|.:|: ....|.||.||||: |.|..|:|...|.::..|:|..|.|.||
 Worm  1788 SNTTAGYECICPAGKTGKNCQLEAPKQMCPSGWWGTFPRCRRCSCAQTKDYEAQCDKKTGACQCK 1852

Human  2063 EFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQCPCRPGALGRQCNSC---DSPFAEVTASGCRV 2124
            :.|:..  .:.|:.|:| ..|:.|..|:. .|.|.|...|:||:|:.|   |......|.. ||.
 Worm  1853 KSHFST--INGCVKCEC-GFGADSTECSA-DGHCKCNGDAVGRRCDRCSRFDHQLDSKTLK-CRP 1912

Human  2125 LYDACPKSLRSGVWWPQTKFGVLATVPCPRGALGAAVRLCDEAQGWLEPDLFNCTSPAFRELSLL 2189
            :...||..:...:.||.::.|.:....||.|..|.|.|.|.|...|.:.:.:|||.|   |.|::
 Worm  1913 VSGKCPSEIEYSIQWPASQKGSIVRQSCPVGESGLATRKCLETGRWSDVNAWNCTRP---EYSIM 1974

Human  2190 LDGLELNKTALDTMEAKKLAQRLREVTGHTDHYFSQDVRVTARLLAHLLAFESHQQGFGLTATQD 2254
            ::..|:       :|..||...:...|........::.::.|..|:.|:.:|......|....:|
 Worm  1975 VNKFEI-------LEPSKLLTMVANATNTESSIRGRNQQIAAEALSRLVDYEQSMPMKGRAHIKD 2032

Human  2255 AHFNENLLWAGSALLAPETGDLWAALGQRAPGGSPGSAGLVRHLEEYAATLARNME-LTYLNPMG 2318
            ..|.|.|:.:...:::.:..|.::.              |:..|..||.|:|...| :.:|:|..
 Worm  2033 MKFTEKLIESLGRVMSEQPADEYST--------------LISKLWNYAETVAEIHENVNFLSPFF 2083

Human  2319 LVTPNIMLSIDRMEHPSSPRGARRYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSS 2383
            :...:|:.:.|:::.      ....|::::.:            .|.|:..||         ..:
 Worm  2084 VANDHIVFASDKLDF------GNILPKFNNFV------------DLRPTGFPR---------VRA 2121

Human  2384 IENSTTS---SVVPPPAPPEPE-PGISIIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVV 2444
            |...||.   |:||.|.....| |.|:|                              |.|:   
 Worm  2122 IVTGTTQVVYSIVPYPRCNRCENPMIAI------------------------------VANT--- 2153

Human  2445 SVAVFHGRNFLRGILESPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSH 2509
                           ..|:.:||.:.:........||::|     |:.|.||||...|:..|.:|
 Worm  2154 ---------------SDPVIVEFEIEEDDGWKYPECVRFD-----EKSGTWTARGAALIGLNLTH 2198

Human  2510 ARCRCSRTGTFGVLMD--ASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNVR 2572
            |.|..:|.|.|.:.::  :|...|:   .::..:.:..:..|::....|:..:.||.||||::..
 Worm  2199 AACEYNRIGVFTMFVNDQSSSIVRV---AQMDNMTSPAIAGVALFLCFLSILLTLSRRSLKTHSV 2260

Human  2573 GIHANVAAALGVAELLFLLGIHRTH-NQLVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQVEPRN 2636
            .|...:..|:.:..|.|   :|:|. ||..|.....:|.:...:.|||||:.||::|||..:   
 Worm  2261 RIGFILFFAINILNLFF---VHKTAINQAYCPVRNAMLSFTSSAPFAWLFLYGLYIYRMLAD--- 2319

Human  2637 VDRGAMRFYHALGWGVPAVLLGLAVG------LDPEGYGNPDFCWISVHEPLIWSFAGPVVLVIV 2695
                        |...|::...|.||      :....:...|.|.:|.|..|.|....|:.|.::
 Worm  2320 ------------GSSSPSLTTSLLVGIVFPCLISFTTFFVTDQCSLSPHLWLFWCIILPIGLFLL 2372

Human  2696 MNGTMFLLAARTSCSTGQRE------AKKTSALTLRSSFLLLLLVSASWLFGLLA---------- 2744
            ::    ..||.||......:      ||......:...|:|.:......|.||.|          
 Worm  2373 LS----FYAAATSVLVSLHKKYDVFVAKYNVKRAVFQHFILTIFTLGMTLTGLFANQLPLPMEIM 2433

Human  2745 -VNHSILAFHYLHAGLCGLQGLAVLLLFCVLNADARAA------WM--------------PACLG 2788
             ::.||:   ||.|.|       |:.|:||.:...:|:      |:              |.|..
 Worm  2434 EISQSII---YLIAAL-------VIFLWCVCDITTKASDSNPSMWLDNQKSVMAESTMADPQCAS 2488

Human  2789 --------RKAAPEEARPAPGLGPGAYNNTALFEESGLIRITL--GASTVSSVSSARSGRTQDQD 2843
                    ....|.::...|.:.|..:.:|::.|.....|:.|  ....::.:||      .||.
 Worm  2489 PLLSPRHQHHEVPMDSEWVPDVNPSNHYHTSINEPDTPRRLLLPQNRDVINILSS------PDQI 2547

Human  2844 SQRGRSYL-RDNV--LVRHGSAADHTD 2867
            ...|..:: |:|:  |.|..||.|..|
 Worm  2548 LNEGVGHVYRNNMGSLPRLRSAQDEAD 2574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CELSR3NP_001398.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..112
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..199
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..306 1/1 (100%)
Cadherin_repeat 330..429 CDD:206637 37/98 (38%)
Cadherin_repeat 437..541 CDD:206637 34/103 (33%)
Cadherin_repeat 550..647 CDD:206637 35/96 (36%)
Cadherin_repeat 655..752 CDD:206637 31/96 (32%)
Cadherin_repeat 760..854 CDD:206637 27/95 (28%)
Cadherin_repeat 862..957 CDD:206637 36/94 (38%)
Cadherin_repeat 965..1063 CDD:206637 40/100 (40%)
Cadherin_repeat 1071..1165 CDD:206637 33/100 (33%)
Cadherin_repeat 1185..1266 CDD:206637 21/80 (26%)
EGF_CA 1437..1471 CDD:238011 12/33 (36%)
EGF_CA 1481..1514 CDD:238011 8/33 (24%)
LamG 1517..1700 CDD:238058 47/194 (24%)
EGF_CA 1726..1758 CDD:238011 14/43 (33%)
LamG 1764..1921 CDD:238058 37/162 (23%)
EGF_CA 1948..1982 CDD:238011 9/34 (26%)
EGF_CA 1982..2020 CDD:238011 11/38 (29%)
Laminin_EGF <2003..2042 CDD:278482 17/40 (43%)
EGF_Lam 2039..>2063 CDD:238012 8/23 (35%)
EGF_Lam 2076..>2114 CDD:238012 14/40 (35%)
HormR 2126..2185 CDD:214468 18/58 (31%)
GAIN 2205..2448 CDD:293098 42/247 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2361..2399 11/40 (28%)
GPS 2476..2529 CDD:197639 18/54 (33%)
7tm_4 2557..2767 CDD:304433 57/233 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2888..2927
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2978..3006
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3086..3243
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3256..3312
fmi-1NP_506256.3 Cadherin_repeat 170..266 CDD:206637 37/98 (38%)
Cadherin_repeat 274..371 CDD:206637 34/103 (33%)
Cadherin_repeat 379..475 CDD:206637 35/97 (36%)
Cadherin_repeat 486..577 CDD:206637 31/93 (33%)
Cadherin_repeat 686..780 CDD:206637 36/94 (38%)
Cadherin_repeat 788..888 CDD:206637 40/100 (40%)
Cadherin_repeat 896..996 CDD:206637 33/100 (33%)
EGF_CA 1252..1287 CDD:238011 12/34 (35%)
LamG 1333..1504 CDD:238058 47/194 (24%)
LamG 1582..1716 CDD:238058 35/158 (22%)
EGF_CA 1774..1808 CDD:238011 11/35 (31%)
EGF_Lam 1865..1911 CDD:238012 15/48 (31%)
HormR 1917..1974 CDD:214468 20/59 (34%)
GPS 2170..2218 CDD:197639 17/52 (33%)
7tm_GPCRs 2237..2455 CDD:421689 63/249 (25%)
TM helix 2 2258..2284 CDD:410628 6/28 (21%)
TM helix 3 2289..2315 CDD:410628 8/25 (32%)
TM helix 4 2326..2346 CDD:410628 3/19 (16%)
TM helix 5 2356..2383 CDD:410628 9/30 (30%)
TM helix 6 2400..2435 CDD:410628 6/34 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C161463588
Domainoid 1 1.000 94 1.000 Domainoid score I5169
eggNOG 1 0.900 - - E2759_KOG4289
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 926 1.000 Inparanoid score I183
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48446
OrthoDB 1 1.010 - - D16905at33208
OrthoFinder 1 1.000 - - FOG0001609
OrthoInspector 1 1.000 - - otm15547
orthoMCL 1 0.900 - - OOG6_103211
Panther 1 1.100 - - O PTHR24026
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3194
SonicParanoid 1 1.000 - - X912
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.840

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