Protein Alignment EGF and arr

DIOPT Version :10

• Sequence 1: NP_001954.2
• Gene: EGF / 1950
• HGNCID: 3229
• Length: 1207
• Species: Homo sapiens
• Sequence 2: NP_524737.2
• Gene: arr / 44279
• FlyBaseID: FBgn0000119
• Length: 1678
• Species: Drosophila melanogaster
• Alignment Length: 818
• Identity: 198/818 - (24%)
• Similarity: 336/818 - (41%)
• Gaps: 204/818 - (24%)

Human     5 LIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFS--HGNSIFRI--DTEGTN 65
            |:|...:.:.:.:.::..|...|    .:|....|..|.....|:|:  |...:..|  .|.|..
  Fly    50 LLICFGISNSWQYKNVHMPSSSS----LIASPPASAFVNTPATLLFTTRHDIQVANITRPTGGPQ 110

Human    66 YEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV---------SGM 121
            .:.:|.|...::.:||:|.:..:.|.|..|::::....|.|..:.:....|..         .|:
  Fly   111 IDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGL 175

Human   122 AINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWS--SEVAGSLY 183
            |::|..:::.|::.::..|.|..:.|....:|. :.|..|..|||.|..:.:.|:  .|.. .:.
  Fly   176 AMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGEYP-KIE 239

Human   184 RADLDGVGVKALLETSEKI---TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGS----VHIS 241
            ||.:||..:..:....|.:   ..:::|:.::.::|    .:|.:..|.....||.|    |:..
  Fly   240 RASMDGDPLSRMTLVKEHVFWPNGLAVDLKNELIYW----TDGKHHFIDVMRLDGSSRRTIVNNL 300

Human   242 KHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKA 306
            |:|     |:::.:.||::::.|:                |.:|::..:...|||.:  :..|||
  Fly   301 KYP-----FSLTFYDDRLYWTDWQ----------------RGSLNALDLQTRELKEL--IDTPKA 342

Human   307 EDD--TWEP-----EQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWN 364
            .:.  .|:|     |...|....|||          ||||:.|
  Fly   343 PNSVRAWDPSLQPYEDNPCAHNNGNC----------SHLCLLA---------------------- 375

Human   365 HGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVL 429
                   .|:.| :.|.||.|..|:
  Fly   376 -------TNSQG-FSCACPTGVKLI---------------------------------------- 392

Human   430 ERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIR 494
              ...||                                         |:|.|..:.......|.
  Fly   393 --SANTC-----------------------------------------ANGSQEMMFIVQRTQIS 414

Human   495 HMHFDGTDYGTLLSQQMGMV---YALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDV 556
            .:..|..|| |:....:|.|   .|:|:||||..||::......|:||:.||:.....:...|..
  Fly   415 KISLDSPDY-TIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRH 478

Human   557 PEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTD-TGIN 620
            |:|||:||:.|..||||.....|....|:|...|::..|::.:||.|||.|....:||:| ....
  Fly   479 PDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERK 543

Human   621 PRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVG 685
            |::|.:||.|..|:|:.|.:|.||:||.:|.....:||||.|...||:||:|||.||.:..:::.
  Fly   544 PKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLK 608

Human   686 HPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRV-------RLQGSMLKPSSLVVVHPLAKPGAD 743
            |.|.:::.:||::::||...|:.|.:|.||.:|:       .|.|  ||.:.|..|.     |.:
  Fly   609 HLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMG--LKVTRLREVR-----GQN 666

Human   744 PCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCL 781
            .|..:||||.|:|..|.....|.|...:..|:|.:||:
  Fly   667 ACAVRNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCV 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EGF	NP_001954.2	TolB	47..190	CDD:440585	36/158 (23%)
		LDL-receptor class B 1	86..127		9/49 (18%)
		LDL-receptor class B 2	128..169		11/41 (27%)
		LY	152..189	CDD:214531	11/39 (28%)
		LDL-receptor class B 3	170..211		8/45 (18%)
		LDL-receptor class B 4	212..258		10/49 (20%)
		EGF_CA	356..395	CDD:214542	7/38 (18%)
		FXa_inhibition	408..436	CDD:464251	0/27 (0%)
		FXa_inhibition	439..476	CDD:464251	0/36 (0%)
		LDL-receptor class B 5	483..523		11/42 (26%)
		LY	505..546	CDD:214531	16/43 (37%)
		LDL-receptor class B 6	524..566		14/41 (34%)
		LY	547..587	CDD:214531	14/39 (36%)
		LDL-receptor class B 7	567..609		16/41 (39%)
		LY	590..633	CDD:214531	16/43 (37%)
		LDL-receptor class B 8	610..653		17/43 (40%)
		LY	635..676	CDD:214531	20/40 (50%)
		LDL-receptor class B 9	654..696		16/41 (39%)
		LY	677..718	CDD:214531	12/40 (30%)
		FXa_inhibition	745..780	CDD:464251	12/34 (35%)
		O-glycosylated at one site	801..807
		EGF	835..864	CDD:394967
		EGF_CA	870..910	CDD:214542
		EGF_CA	912..940	CDD:429571
		PHA03099	<976..>1014	CDD:165381
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1067..1093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1108..1131
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1177..1207
arr	NP_524737.2	LY	162..201	CDD:214531	6/38 (16%)
		NHL	168..503	CDD:302697	100/486 (21%)
		NHL repeat	172..237	CDD:271320	16/65 (25%)
		LY	252..293	CDD:214531	7/44 (16%)
		NHL repeat	261..298	CDD:271320	7/40 (18%)
		NHL repeat	303..339	CDD:271320	10/58 (17%)
		NHL repeat	341..419	CDD:271320	27/200 (14%)
		NHL repeat	428..476	CDD:271320	15/47 (32%)
		LY	472..511	CDD:214531	15/38 (39%)
		NHL repeat	477..503	CDD:271320	12/25 (48%)
		Ldl_recept_b	534..574	CDD:459654	16/39 (41%)
		LY	558..599	CDD:214531	20/40 (50%)
		LY	600..641	CDD:214531	12/40 (30%)
		FXa_inhibition	668..703	CDD:464251	12/34 (35%)
		YncE	<736..886	CDD:442618
		LY	776..818	CDD:214531
		LY	905..946	CDD:214531
		FXa_inhibition	973..1010	CDD:464251
		YncE	<1047..1191	CDD:442618
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566