DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment EGF and egf

DIOPT Version :9

Sequence 1:XP_016863334.1 Gene:EGF / 1950 HGNCID:3229 Length:1223 Species:Homo sapiens
Sequence 2:NP_001352456.1 Gene:egf / 403045 ZFINID:ZDB-GENE-070922-1 Length:1177 Species:Danio rerio


Alignment Length:1200 Identity:472/1200 - (39%)
Similarity:671/1200 - (55%) Gaps:127/1200 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    28 CPEGTLAGNGNSTCVVWSLSSHPGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYN 92
            |..|.....||..||        .|.|:||...||||.|::.:|.:..::|..||.|:::|||.:
Zfish    33 CWGGRAWAAGNFNCV--------EPEPYLIVGLGNSIQRMNLDGGDRRRIVSRAGRSILLDFHLS 89

Human    93 EKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNN 157
            |..::|.|.:...::|..|:|:|::::.:..|.::|:.::||...|:|||..||.|...|..|.|
Zfish    90 EWTMFWADTQTGQIRRAGLDGTRRQKLLSSVKGITGLVVDWIENSVLWSNADEGTIQRMDTDGRN 154

Human   158 SHILLSALKYPANVAVDPVERFIFWSSEVA-GSLYRADLDGVGVKALLETSEKITAVSLDVLDKR 221
            ..::|..|..|..|.|||.||:|||.|:.| .|:.|:|:.|..:..:|:.::::..:::|..|:|
Zfish   155 DRVVLRNLSQPRGVVVDPNERYIFWLSDGATSSIQRSDMTGKMMSTVLKVADRLKVLAVDHRDRR 219

Human   222 LFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGK 286
            |||:|..:.| ::.:.||:|||..:::.....:.....|::|.|.::.|..|.|||...||:||.
Zfish   220 LFWVQQGQRG-HTAMGSCNYDGNIINVFNQQFRPQSLRMTIFLDYVYLSDSKSKTITRLNKYTGG 283

Human   287 DMVRINLHSSFVP--LGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMC 349
            .  :.|:.|..:|  ..::|||||:.||..|    .|....|....|.|.. ||.....:.||.|
Zfish   284 R--QENVSSQRMPHSPADVKVVHPINQPVVE----TPFTPGCSRHTGECVK-VCSSHTDTGLCGC 341

Human   350 AEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVS 414
            .:|:.||:....|||||||:.|||||:|||:|.||||:||||.|::||||.|.|.:...|.....
Zfish   342 KDGFTLSKHGNICEDVNECSLWNHGCSLGCENVPGSYFCTCPEGYLLLPDLKTCQENKPCVGKAV 406

Human   415 ECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQL 479
            :|.|.||.|::|.:|.|||||:|..||::|:||.|.|.|||||:||.|.|..|.|:|.|||.:|.
Zfish   407 DCDHACVHTAQGDMCVCPEGSLLNPDGQSCTGCFSADRGGCSQMCVTLYPGRWVCECHPGYQIQP 471

Human   480 DEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWI 544
            |.|.|||:||...|||||..|:|.::.||.....||.:..|.:.|:|:|||.||:|||...||.|
Zfish   472 DGKHCAATGPPADLLFANIVDLRKINTDGKLSIKLLEKPGGNITAVDYDPVTNKVYFADKGLKHI 536

Human   545 ERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPR 609
            |||::|...||.|:..|::.||.||||||.|:.||||.|.|.|.||.|||...:|...|||.:||
Zfish   537 ERASLDEGFRELLVSTGLNSPEALAVDWIQRKLYWTDSGLSSISRSSLNGLDREIFINENIQKPR 601

Human   610 GIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVI 674
            |||:||.|::::|||.|..|.:|.|.|....|..:.|:.|:.|||:.:|..:.:|||||...|||
Zfish   602 GIALHPQAQKIYWTDMGDRPAVERSGLDKDLREAVVSTGLVSPSGLAVDHGSQRLYWCDMSTSVI 666

Human   675 EMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSL 739
            |.||||||.||.::||.|..||.:||||:.:|.||.....:.|::.|:|::..||....::|::|
Zfish   667 ESANLDGSHRRVISQNQVDRPFDIAVFENVLWVSDLENHLIFRLDMRSGQNPERLLVDSIQPAAL 731

Human   740 VVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDG--HQLLAGGEV 802
            ||||||||||||.||..||||..:|..|||...|||....:.::|||.|..::.  .:...||..
Zfish   732 VVVHPLAKPGADVCLDGNGGCAQVCVSRLGLPHCSCHTNHVLSADGKGCRMINASFSESSEGGSN 796

Human   803 D------LKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDA 861
            |      |.::.|||                 .||..|.||||||||..:.|.:.|:|..:...|
Zfish   797 DGLRNKTLNDESTPL-----------------AMLYTEKMVSDQDDCFSLSCVVNAQCFLQEGRA 844

Human   862 TCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQL 926
            .|||::||.|||:||.|:|||:.|:..|..:.::|:||.|||.|:|..|:.|||.||:|||||:|
Zfish   845 VCQCVRGFTGDGELCVDVDECKAGLADCSVSEAECVNTAGGYFCQCKNGFSGDGHHCVDIDECRL 909

Human   927 GEHSCGENASCTNTEGGYTCMCAGRLSEPGLIC----------PDSTPPPHLREDDHHYSVRNSD 981
            ..|.|..||.|.|..|.|.|.|....:..|..|          |.:..||.:.....|   :|..
Zfish   910 DLHDCDVNAECLNAVGEYQCRCRSGFTGTGFSCQAEFNGTSLWPSTASPPDVTSTLQH---KNGV 971

Human   982 SECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAV 1046
            ..||.:||.|||:||||.|...::.||||||:||:|||||:.||:||||:.|..|:::. :|:||
Zfish   972 QSCPSTHDSYCLYDGVCFYFPDMESYACNCVLGYMGERCQFSDLEWWELQQAEEGKRRN-MVIAV 1035

Human  1047 CVVVLVMLLLLSLWGAHYYRTQKLL-------SKNPKNPYEESSRDVRSRRP------------A 1092
            |:|:|:.:|.::......||.::..       |....:..|:|..:..:..|            |
Zfish  1036 CIVLLITILSIAACITFCYRPKRHFGGCSLQDSVGEMSASEDSFTETTTATPEVYVVLDTSTCTA 1100

Human  1093 D--------TEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGQFLSLAPGSMQPTSWRQ 1149
            |        |....||||.                        |..| :|.|...|.:|      
Zfish  1101 DKVLHVQSTTSTICSSCPT------------------------QTGD-RFSSEEAGKLQ------ 1134

Human  1150 EPQLCGMGTEQGCWIPVSSDKGSC--PQVM 1177
                     ..||.:.|:....||  |:::
Zfish  1135 ---------RDGCSLAVAICSVSCDIPKIL 1155

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EGFXP_016863334.1 None
egfNP_001352456.1 NHL 34..>197 CDD:302697 61/170 (36%)
NHL repeat 81..121 CDD:271320 11/39 (28%)
NHL repeat 123..160 CDD:271320 13/36 (36%)
LY 156..197 CDD:214531 18/40 (45%)
vWFA <351..394 CDD:320736 29/42 (69%)
FXa_inhibition 441..476 CDD:317114 20/34 (59%)
LY 506..546 CDD:214531 20/39 (51%)
LY 549..589 CDD:214531 23/39 (59%)
LY 590..629 CDD:214531 19/38 (50%)
LY 634..676 CDD:214531 21/41 (51%)
FXa_inhibition 745..780 CDD:317114 16/34 (47%)
EGF_3 865..901 CDD:315598 15/35 (43%)
EGF_3 907..942 CDD:315598 13/34 (38%)
PHA02887 <959..1058 CDD:333467 45/102 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C194344264
Domainoid 1 1.000 210 1.000 Domainoid score I12128
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1483
Inparanoid 1 1.050 911 1.000 Inparanoid score I2764
NCBI 1 1.000 - -
OMA 1 1.010 - - QHG40478
OrthoDB 1 1.010 - - D29959at7742
OrthoFinder 1 1.000 - - FOG0009585
OrthoInspector 1 1.000 - - oto50992
orthoMCL 1 0.900 - - OOG6_116121
Panther 1 1.100 - - LDO PTHR46513
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X7333
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 1 1.500 - -
1515.410

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