Protein Alignment EGF and cue

DIOPT Version :9

• Sequence 1: XP_016863334.1
• Gene: EGF / 1950
• HGNCID: 3229
• Length: 1223
• Species: Homo sapiens
• Sequence 2: NP_612113.2
• Gene: cue / 38174
• FlyBaseID: FBgn0011204
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 704
• Identity: 155/704 - (22%)
• Similarity: 258/704 - (36%)
• Gaps: 199/704 - (28%)

Human   466 SWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPV 530
            ||:......:  :.||.|.........|::.|  |::|.:              |.:::|..|.:
  Fly    47 SWQTIATAAH--EFDELSALTFDESEELIYFN--DLKHRN--------------GSIFSLKRDLI 93

Human   531 ENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGK 595
            ...    |.|.:.|.|.             |.:...|||.|.:....:|:|..:..|..:.::|.
  Fly    94 AAN----HVAEQTIART-------------GNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGS 141

Human   596 RSKIITKENISQ---PRGIAVHPMAKRLFWTDTGI-NPRIESSSLQGLGRLVIASSDLIWPSGIT 656
            .:..:..:..::   |.|:||....::|:||::.: :|.:|..:|.|..|.||.||::..|.||.
  Fly   142 ATPQVLVDLSAEGGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIV 206

Human   657 IDFLTDKLYWCDAKQSV---IEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSD------WAM 712
            :|.|:|:|:|.|..:.|   :|.:.||||.|:.:.::....|..:||..|.::::|      |:.
  Fly   207 VDQLSDRLFWIDDLKGVFFSVESSKLDGSDRQVVLKDKHHEPLNLAVTNDAIYWTDRTTRAVWSH 271

Human   713 PSVMRVNKRTGKDRVRLQGSMLKP------SSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTA 771
            |.|..:...|..          ||      .|.....|  :|.|:.|....  ..::.::..|..
  Fly   272 PKVPVIKVTTTS----------KPDEEDSTDSTDFKDP--EPVAEDCPLVR--VANLSEEARGIV 322

Human   772 WCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNIT-ESQHMLVAEI 835
               .|.||.:.      |..|.|......:|             |.||.|.:.. |.:.:|..:|
  Fly   323 ---ARTGFYQR------LQKDHHCASIVRKV-------------KERVDEQSRKFEIRSLLDQKI 365

Human   836 MVSDQDDCAPVGCSMYARCISEGE--DAT--CQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKC 896
            .|.:.:           ||:::||  .||  |.|..||  .|..| :|.||.   ..|  ....|
  Fly   366 KVLEDE-----------RCMNDGEYRAATDLCICPTGF--KGSRC-EIRECH---NYC--VHGTC 411

Human   897 INTEGGY-VCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICP 960
            ..:|..| .|.|..|::|        :.|:|...|    ..|.|  ||:..:.......|...||
  Fly   412 QMSELAYPKCYCQPGFKG--------ERCELSVCS----GLCLN--GGHCRVSKDENEAPSCECP 462

Human   961 DSTPPPHLREDDHHYSVRNSDSECPLSHDGYC--LHDGVCMYIEALDKYACNCVVGYIGER---- 1019
            .........:        ||...|.|    :|  |.....||:    .:.|:.:...:.:.
  Fly   463 AKFGGARCEQ--------NSTEICSL----FCRLLKHEPEMYV----PFGCHSICEELAQDNSTN 511

Human  1020 ---CQYRDLK-------WWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKN 1074
               .||:.|:       |         ....:|::.|.:|..::|:.:.:.|..  |..|
  Fly   512 IAIPQYQHLEVCLTPRVW---------TSSVIIILVVGIVSSLLLVAVIVQGIR--RLYK----- 560

Human  1075 PKNPYEESSRDVR-------------SRRPADTED---------GMSSCPQPWF 1106
            ||.|....:..||             :.||..||.         .|:.|..|.|
  Fly   561 PKRPRIRKTFVVRKQARTNSAGDTPLTNRPLATEQCEITIENCCNMNICETPCF 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EGF	XP_016863334.1	None
cue	NP_612113.2	LY	101..141	CDD:214531	10/52 (19%)
		Ldl_recept_b	167..208	CDD:278487	15/40 (38%)
		LY	193..237	CDD:214531	19/43 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S7221
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760