DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EGF and rme-2

DIOPT Version :9

Sequence 1:	XP_016863334.1	Gene:	EGF / 1950	HGNCID:	3229	Length:	1223	Species:	Homo sapiens
Sequence 2:	NP_500815.2	Gene:	rme-2 / 177329	WormBaseID:	WBGene00004374	Length:	925	Species:	Caenorhabditis elegans

Alignment Length:	750	Identity:	168/750 - (22%)
Similarity:	275/750 - (36%)	Gaps:	205/750 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   225 IQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMV 289
            :...|.|..::..|.|:     |...|......||..   |....|.:.|       .|:|.
Worm   169 VNCTRRGHENMQSSTDF-----HDDVHLVDPTFFANE---DNKCRSGYTM-------CHSGD--- 215

Human   290 RINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYA 354
             :.:..||:..|:|..          ||.  .::|.|:....:....:.||....|.|..|..|:
Worm   216 -VCIPDSFLCDGDLDC----------DDA--SDEKNCQTNAPSEEEYLSGQADHMHSCSAAGMYS 267

Human   355 LSRDRKYC----EDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSE 415
                   |    .::..|...|..|. |.|.        ||:|.   .:.|.|.:   |.|  ..
Worm   268 -------CGTKGSEIGVCIPMNATCN-GIKE--------CPLGD---DESKHCSE---CAR--KR 308

Human   416 CSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCS---QLCVPLSP---VSWECDCFPG 474
            |.|.|:.|..|..|.|.||..|..||.||.     |...|:   .||.....   .|:.|.|..|
Worm   309 CDHTCMNTPHGARCICQEGYKLADDGLTCE-----DEDECATHGHLCQHFCEDRLGSFACKCANG 368

Human   475 YDLQLDEKSC---AASGPQPFLLFANSQDIRHMHF----DGTDYGTLLSQQM---GMVYALDHDP 529
            |:|:.|..||   ..:.|:.:|..:...::|.|..    ||::|..:  |:.   |.:.::|...
Worm   369 YELETDGHSCKYETTTTPEGYLFISLGGEVRQMPLADFTDGSNYSPI--QKFAGHGTIRSIDFMH 431

Human   530 VENKIYFAHTALKWIERANMDG------SQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSL-- 586
            ..||::.:.:.    |..:..|      :...|::.|.|.....:||||||...::|.:..|.
Worm   432 RNNKMFMSISD----EHGDPTGELSVSDNGLMRVLRENVIGVSNVAVDWIGGNVFFTQKSPSPSA 492

Human   587 -IGRSDLNGK--RSKIITKENISQPRGIAVHPMAKRLFWTDTGIN-PRIESSSLQGLGRLVIASS 647
             |....::|.  |..|..||.....||:.||||...:.|.|:... .||..:::.|....::..:
Worm   493 GISICTMSGMFCRRVIEGKEQGQSYRGLVVHPMRGLIIWIDSYQKYHRIMMANMDGSQVRILLDN 557

Human   648 DLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAM 712
            .|..||.:.||::...:|:.|.::.:||..|:|..:||.:..|.|.||:.:|.|..:::::||
Worm   558 KLEVPSALAIDYIRHDVYFGDVERQLIERVNIDTKERRVVISNGVHHPYDMAYFNGFLYWADW-- 620

Human   713 PSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAK---------------PGADPCLYQNGGCEH 762
                      |.:.:::|......||..|:|...:               |.::|||...  |..
Worm   621 ----------GSESLKVQEMTHHHSSPQVIHTFNRYPYGIAVNHSLYQTGPPSNPCLELE--CPW 673

Human   763 IC-----KKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSED 822
            :|     ...:.||.|.|.:|:..:....:|                   :.|:.|     ..|:
Worm   674 LCVIVPKSDFIMTAKCVCPDGYTHSVTENSC-------------------IPPVTI-----EDEE 714

Human   823 NITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVP 887
            |:.:..|                :|.::.|                           :.||.||.
Worm   715 NLEKLSH----------------IGSALMA---------------------------EYCEAGVA 736

Human   888 VCPPASSKCINTEGG----YVCRCSEGYQGDGIHC 918
            .....:.:.:..|.|    .||.|...|  ||.:|
Worm   737 CMNGGACRELQNEHGRAHRIVCDCEGPY--DGQYC 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EGF	XP_016863334.1	None
rme-2	NP_500815.2	LDLa	37..69	CDD:238060
		LDLa	75..109	CDD:238060
		LDLa	137..171	CDD:238060	0/1 (0%)
		FXa_inhibition	309..337	CDD:291342	12/27 (44%)
		vWFA	<337..375	CDD:294047	11/42 (26%)
		Ldl_recept_b	527..568	CDD:278487	8/40 (20%)
		LY	552..594	CDD:214531	11/41 (27%)
		LY	595..634	CDD:214531	11/50 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161472349
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46513
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840