DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EFNA5 and Ephrin

DIOPT Version :9

Sequence 1:	NP_001953.1	Gene:	EFNA5 / 1946	HGNCID:	3225	Length:	228	Species:	Homo sapiens
Sequence 2:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	230	Identity:	64/230 - (27%)
Similarity:	101/230 - (43%)	Gaps:	48/230 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     4 VEMLTLVFL--VLWMCVFSQDPGSKAVADRYAVYWNSSNP--RFQRGDYHIDVCIN--------D 56
            |.:|||:.:  ||...:.|       .|..:.::||:||.  |....|:.|||  |        |
  Fly   194 VTLLTLICMETVLLSTMSS-------CAKTFYMHWNTSNSIFRIDNTDHIIDV--NKGNLAFEFD 249

Human    57 YLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWE-CNRPHSPNGPLKFSEKFQL 120
            .:.:.||.||....|::||:|::|.|:...|..|..|:...:... |::|..   .:.|:..|:.
  Fly   250 QVHIICPVYEPGTFENETEKYIIYNVSKVEYETCRITNADPRVIAICDKPQK---LMFFTITFRP 311

Human   121 FTPFSLGFEFRPGREYFYISSAIPDN------GRRSCLKLKVFVR---------PTNSCMKTIGV 170
            |||...|.||.||.:|::||::..|:      ||.|...:||..:         .|.:...:..|
  Fly   312 FTPQPGGLEFLPGNDYYFISTSSKDDLYRRIGGRCSTNNMKVVFKVCCAPEDNNKTTALSNSKSV 376

Human   171 HDRVFDVNDKVENSLEPADDTVHESAEPSRGENAA 205
            .|....:|..:.|:        .||...|.|.|.|
  Fly   377 TDTGGAINVNIANN--------DESHVNSHGNNIA 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EFNA5	NP_001953.1	Ephrin-A_Ectodomain	30..159	CDD:259896	45/145 (31%)
EFNA5	NP_001953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..205		5/18 (28%)
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	45/145 (31%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3858
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11304
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840