DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EFNA3 and Ephrin

DIOPT Version :9

Sequence 1:	NP_004943.1	Gene:	EFNA3 / 1944	HGNCID:	3223	Length:	238	Species:	Homo sapiens
Sequence 2:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	221	Identity:	56/221 - (25%)
Similarity:	92/221 - (41%)	Gaps:	52/221 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     7 LLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVN--------DYLDIYC 63
            ||.|:.:...||..::     :......::||:||...|.:.....::||        |.:.|.|
  Fly   196 LLTLICMETVLLSTMS-----SCAKTFYMHWNTSNSIFRIDNTDHIIDVNKGNLAFEFDQVHIIC 255

Human    64 PHYNSSGVGPGAGPGPG---GGAEQYVLYMVSRNGYRTCNASQGFKR--WECNRPHAPHSPIKFS 123
            |.|.           ||   ...|:|::|.||:..|.||..:....|  ..|::   |...:.|:
  Fly   256 PVYE-----------PGTFENETEKYIIYNVSKVEYETCRITNADPRVIAICDK---PQKLMFFT 306

Human   124 EKFQRYSAFSLGYEFHAGHEYYYISTPT-----HNLHWKCL--RMKVF--VCCA------STSHS 173
            ..|:.::....|.||..|::||:|||.:     ..:..:|.  .|||.  ||||      :|:.|
  Fly   307 ITFRPFTPQPGGLEFLPGNDYYFISTSSKDDLYRRIGGRCSTNNMKVVFKVCCAPEDNNKTTALS 371

Human   174 GEKPVPTLPQFTMGPNVKINVLEDFE 199
            ..|.|.     ..|..:.:|:..:.|
  Fly   372 NSKSVT-----DTGGAINVNIANNDE 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EFNA3	NP_004943.1	Ephrin-A_Ectodomain	31..166	CDD:259896	40/156 (26%)
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	40/154 (26%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153158
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3858
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11304
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840