DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rax and al

DIOPT Version :9

Sequence 1:	NP_038861.2	Gene:	Rax / 19434	MGIID:	109632	Length:	342	Species:	Mus musculus
Sequence 2:	NP_722629.1	Gene:	al / 33208	FlyBaseID:	FBgn0000061	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	409	Identity:	111/409 - (27%)
Similarity:	146/409 - (35%)	Gaps:	143/409 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse    46 GILDTFPAERSSRSSKERDP----RLGAQPACPKAPAGGSESSPPAAPGFVPEYEATRPCYPKEQ 106
            ||.:....|...:.:|...|    .:...|....|.||.:.:...:..|..|            .
  Fly     2 GISEEIKLEELPQEAKLAHPDAVVLVDRAPGSSAASAGAALTVSMSVSGGAP------------S 54

Mouse   107 GEARPSPGLSVGPAAGDSKL-SEEEPPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELA 170
            |.:..|.|.:...:.|:|.. ::|..||:|.||.|||||::||.|||:||.::|||||::|||||
  Fly    55 GASGASGGTNSPVSDGNSDCEADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELA 119

Mouse   171 GKVNLPEVRVQVWFQNRRAKWRRQEKLEVSS---------------------------------- 201
            .|:.|.|.|:||||||||||||:|||:...|
  Fly   120 MKIGLTEARIQVWFQNRRAKWRKQEKVGPQSHPYNPYLPGGAATMQTVVGAALPPNPFTHLGFQL 184

Mouse   202 -----------------MKLQDSPLL------SFSRSPP-----------------SSALA---- 222
                             ..|..:|::      .|.|:||                 .|.||
  Fly   185 RKPFDAQHAANLAAFRYPHLSAAPMIPSGYFNQFQRAPPHMLPHGMAGMYSPSSSFQSLLANMTA 249

Mouse   223 -----PLGTGPGSGSGPPGSALPLEPWLGPPLPGGGATALQSLPGFGPPGQGLPASYTPPPPFLN 282
                 |||..|....|.|....|......||.......|.|.        |..|.::.|||....
  Fly   250 VPRGTPLGKPPALLVGSPDLHSPNHMLASPPTSPASGHASQH--------QQHPTAHPPPPQAPP 306

Mouse   283 SAPLGPGLQQLGP-----------------------------------PPAYPCAPAFGDKFSLE 312
            ..|:|....||.|                                   ||....||....:.:..
  Fly   307 QMPVGVQPAQLSPQHLVGIALTQQASSLSPTQTSPVALTLSHSPQRQLPPPSHQAPPPPPRAATP 371

Mouse   313 EAYPRNSSIAALRLKAKEH 331
            ....|.||||||||||:||
  Fly   372 PEDRRTSSIAALRLKAREH 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rax	NP_038861.2	Octapeptide motif	33..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..140		22/98 (22%)
		Homeobox	140..192	CDD:278475	36/51 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..295		28/118 (24%)
		OAR	316..331	CDD:281777	11/14 (79%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	319..332		12/13 (92%)
		Nuclear localization signal. /evidence=ECO:0000255	325..329		3/3 (100%)
al	NP_722629.1	Homeobox	89..141	CDD:278475	36/51 (71%)
al	NP_722629.1	OAR	374..391	CDD:281777	13/17 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4389
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.970