Protein Alignment Rara and EcR

DIOPT Version :9

• Sequence 1: NP_001170773.1
• Gene: Rara / 19401
• MGIID: 97856
• Length: 462
• Species: Mus musculus
• Sequence 2: NP_001163061.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Alignment Length: 584
• Identity: 151/584 - (25%)
• Similarity: 241/584 - (41%)
• Gaps: 143/584 - (24%)

Mouse     4 NSSSCPTP-------------GGGHLNGYPVPPYAFFFPPMLGGLSPPGALTSL----------- 44
            ||::..||             |||.:.|..:..:|...|..|.|:...|....|
  Fly   147 NSTTPSTPTTPLHLQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGGGVGGLG 211

Mouse    45 -QHQLPVSGYSTPSPATIETQSSSSEEIVPS---------------PPSPPPLPRIYKP-CFVCQ 92
             ||        ||...::.:.||..:::.||               .....|.||:.:. |.||.
  Fly   212 MQH--------TPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCG 268

Mouse    93 DKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFDVGMSKES 157
            |::|||||....|||||||||||:.|:.||.|...:.|.::...|.:||.|||:||..|||..|.
  Fly   269 DRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPEC 333

Mouse   158 V--RNDRNKKKKEAPKPECSESYTLTP---------------------EVGELI----------- 188
            |  .|....|::|....:..:..|.:|                     |:.:|:
  Fly   334 VVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIP 398

Mouse   189 ----EKVRKAHQETFPALC-------------QLGKYTTNNSSEQRVSLDIDLWDKFSELS---- 232
                |.:.|......|:|.             |.|....:....:|:....|..:..:::|
  Fly   399 LLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHI 463

Mouse   233 TKCIIKT----VEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLN 293
            |:..|.|    |||||.||.||.:...||||||||...::::||:..||....|::.|::..:..
  Fly   464 TEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYT 528

Mouse   294 RTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDKVDMLQEPLLEA 358
            |.....||.....:.:..|..|:..:::|:.|..||:|| :|..||..||:...|:.:|...::.
  Fly   529 RDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAI-VIFSDRPGLEKAQLVEAIQSYYIDT 592

Mouse   359 LKVYVRKRRPSRPH--------MFPKMLMKITDLRSISAKGAERVITLKM---EIP--------- 403
            |::|:..|     |        .:.|:|..:|:||::..:.||...:||:   ::|
  Fly   593 LRIYILNR-----HCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDV 652

Mouse   404 GSMPPLIQEML-------ENSEGLDTLSGQSGGGTRDGGGLAPPPGSCSPSLSPSSHRSSPATQ 460
            .::||.:|..|       |..|..:.:....||...  .|:.....|.|.:.:.:.|:..|..|
  Fly   653 HAIPPSVQSHLQITQEENERLERAERMRASVGGAIT--AGIDCDSASTSAAAAAAQHQPQPQPQ 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rara	NP_001170773.1	Modulating	1..87		25/122 (20%)
		DUF3454	19..>68	CDD:371809	12/60 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..77		6/39 (15%)
		NR_DBD_RAR	82..166	CDD:143522	41/86 (48%)
		Hinge	154..182		6/29 (21%)
		NR_LBD_RAR	186..416	CDD:132735	72/292 (25%)
		Required for binding corepressor NCOR1	404..419		5/21 (24%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P10276	408..416		3/14 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..462		8/41 (20%)
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	41/89 (46%)
		NR_LBD_EcR	420..652	CDD:132736	63/237 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840