DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hspa1a and Hsc70-4

DIOPT Version :9

Sequence 1:	NP_034609.2	Gene:	Hspa1a / 193740	MGIID:	96244	Length:	641	Species:	Mus musculus
Sequence 2:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster

Alignment Length:	651	Identity:	523/651 - (80%)
Similarity:	583/651 - (89%)	Gaps:	10/651 - (1%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQN 65
            |:|..|:|||||||||||||||||||||||||||||||||||||||||||||||||||||:||..
  Fly     1 MSKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQ 65

Mouse    66 TVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEI 130
            |:|||||||||||.||.||||||||||:||:...|||::|.||.|.::||||||||||||||||.
  Fly    66 TIFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130

Mouse   131 AEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNV 195
            ||||||..||||||||||||||||||||||||.|||||||||||||||||||||||:...|||||
  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195

Mouse   196 LIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAV 260
            |||||||||||||||:|||||||||:|||||||||||||||||:|||:|||||||||::.||||:
  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260

Mouse   261 RRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAK 325
            |||||||||||||||||||||:||||||||.||||||||||||||.:||||.|::||||||||||
  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAK 325

Mouse   326 MDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQD 390
            :||:.|||:|||||||||||||:||||.|||::||||||||||||||||||||||.||||:.|||
  Fly   326 LDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQD 390

Mouse   391 LLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNL 455
            ||||||.|||||:|||||||:.|||||:||||||||||||||||||||||||||||||||:||||
  Fly   391 LLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455

Mouse   456 LGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQ 520
            ||:||||||||||||||||||||||||||||||||.::||.|.|||||||||||||||:|||||.
  Fly   456 LGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVN 520

Mouse   521 EAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNT 585
            |||:|:.|||.|::.:||||.||||.||||:.::::.||.|:|::|:..:||||.|.|.|||:|.
  Fly   521 EAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQ 585

Mouse   586 LADKEEFVHKREELERVCSPIISGLYQGAGAP------GAGGF----GAQAPKGASGSGPTIEEV 640
            ||||||:.|:::|||.||:|||:.||||||.|      |.||.    ||....||.|:|||||||
  Fly   586 LADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEEV 650

Mouse   641 D 641
            |
  Fly   651 D 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hspa1a	NP_034609.2	PTZ00009	1..641	CDD:240227	521/649 (80%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		329/383 (86%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	324/374 (87%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		102/114 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..641		14/26 (54%)
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	501/610 (82%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	324/374 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		otm43752
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R573
SonicParanoid	1	1.000	-	-		X148
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760