DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EEF1G and GstE12

DIOPT Version :9

Sequence 1:	NP_001395.1	Gene:	EEF1G / 1937	HGNCID:	3213	Length:	437	Species:	Homo sapiens
Sequence 2:	NP_001246500.1	Gene:	GstE12 / 37960	FlyBaseID:	FBgn0027590	Length:	223	Species:	Drosophila melanogaster

Alignment Length:	187	Identity:	37/187 - (19%)
Similarity:	79/187 - (42%)	Gaps:	11/187 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    46 TPEFLRKFPAGKVPAFEGDDGFCVFESNAIAYYVSNEELRGSTPEAAAQVVQWVS-----FADSD 105
            |||||:..|...:|... |....:.:|:||..|:..:..:........::||..:     ..||.
  Fly    43 TPEFLKLNPQHTIPTLI-DGEATIIDSHAICAYLVEKYGQKEQQLYPKELVQRANVDARLHLDSG 106

Human   106 IVPPASTWVFPTLGIMHHNKQATENAKEEVRRILGLLDAYLKTRTFLVGERVTLADITVVCTLLW 170
            .:.....:::..: :.:.:...:.:....:::...:|:.:||.:.:|.|..:|:||...|.|:..
  Fly   107 HLFARLRFLYEPI-LYYGSTDCSIDKIAYIQKCWEILEGFLKDQPYLCGSDLTIADFCAVATVTS 170

Human   171 LYKQVLEPSFRQAFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDAKKFAETQPK 227
            :........|:  ||..:.|.......|.::.|.|:.  .:::......|.||.:.|
  Fly   171 VNDTAPIDEFK--FPKMHAWLKRLAELPYYQEVNGDG--ADELKSIFKAKLAENRGK 223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EEF1G	NP_001395.1	GST_N_EF1Bgamma	4..82	CDD:239342	12/35 (34%)
		GST_C_EF1Bgamma_like	91..213	CDD:198290	21/126 (17%)
		tolA	<212..>278	CDD:236545	4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..268		3/7 (43%)
		EF1G	277..381	CDD:395522
GstE12	NP_001246500.1	GST_N_Delta_Epsilon	4..77	CDD:239343	12/34 (35%)
		GstA	6..201	CDD:223698	31/161 (19%)
		GST_C_Delta_Epsilon	92..210	CDD:198287	21/122 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810