DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EEF1G and GstE5

DIOPT Version :9

Sequence 1:	NP_001395.1	Gene:	EEF1G / 1937	HGNCID:	3213	Length:	437	Species:	Homo sapiens
Sequence 2:	NP_611327.1	Gene:	GstE5 / 37110	FlyBaseID:	FBgn0063495	Length:	222	Species:	Drosophila melanogaster

Alignment Length:	252	Identity:	58/252 - (23%)
Similarity:	89/252 - (35%)	Gaps:	85/252 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    14 RAFKALIAA---QYSGAQVRVLSAPPHFHFGQTNRTPEFLRKFPAGKVPAFEGDDGFCVFESNA- 74
            ||.|..:||   .|....|.:        .||...:.|:|:|.|...||..| |||..:::|:|
  Fly    16 RAVKLTLAALQLPYEFVNVNI--------SGQEQLSEEYLKKNPEHTVPTLE-DDGNYIWDSHAI 71

Human    75 IAYYVSNEELRGSTPEAAAQVVQWVSFADSDIVPPA--------------STWVFPTLGIMHHNK 125
            |||.||                   .:||||.:.|.              .|.|....||....|
  Fly    72 IAYLVS-------------------KYADSDALYPRDLLQRAVVDQRLHFETGVVFANGIKAITK 117

Human   126 QATENA-----KEEVRRILGLLD---AYLKTRTFLVGERVTLADITVVCTLLWLYKQVLEPSFRQ 182
            ....|.     ||....|:.:.|   .:|....::.|:::|:||.:::.::..|...|  ...|.
  Fly   118 PLFFNGLNRIPKERYDAIVEIYDFVETFLAGHDYIAGDQLTIADFSLISSITSLVAFV--EIDRL 180

Human   183 AFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDAKKFAETQPKKDTPRKEKGSRE 239
            .:|....|                |:..||:..::             ....||:||
  Fly   181 KYPRIIEW----------------VRRLEKLPYYE-------------EANAKGARE 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EEF1G	NP_001395.1	GST_N_EF1Bgamma	4..82	CDD:239342	26/71 (37%)
		GST_C_EF1Bgamma_like	91..213	CDD:198290	27/143 (19%)
		tolA	<212..>278	CDD:236545	5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..268		4/19 (21%)
		EF1G	277..381	CDD:395522
GstE5	NP_611327.1	GstA	4..196	CDD:223698	54/225 (24%)
		Thioredoxin_like	4..77	CDD:294274	24/69 (35%)
		GST_C_Delta_Epsilon	91..209	CDD:198287	27/149 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810