DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EEF1G and GstE4

DIOPT Version :9

Sequence 1:	NP_001395.1	Gene:	EEF1G / 1937	HGNCID:	3213	Length:	437	Species:	Homo sapiens
Sequence 2:	NP_611326.1	Gene:	GstE4 / 37109	FlyBaseID:	FBgn0063496	Length:	222	Species:	Drosophila melanogaster

Alignment Length:	221	Identity:	49/221 - (22%)
Similarity:	94/221 - (42%)	Gaps:	45/221 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    29 VRVLSAPPHF----HFGQTNRTPEFLRKFPAGKVPAFEGDDGFCVFESNAI-AY----YVSNEEL 84
            ::.|..|..|    .|.:.|.:.:|.:|.|...||..:.||. |:::|:|| ||    |..::||
  Fly    22 LKALDLPFEFVFVNLFEKENFSEDFSKKNPQHTVPLLQDDDA-CIWDSHAIMAYLVEKYAPSDEL 85

Human    85 RGSTPEAAAQVVQWVSFADSDIV---------PPASTWVFPTLGIMHHNKQATENAKEEVRRILG 140
            ........|:|.|.:.| :|.::         .|...:..|||         ..|..:.:.::..
  Fly    86 YPKDLLQRAKVDQLMHF-ESGVIFESALRRLTRPVLFFGEPTL---------PRNQVDHILQVYD 140

Human   141 LLDAYLKTRTFLVGERVTLADITVVCTL--LWLYKQVLEPSFRQAFPNTNRWFLTCINQPQFRAV 203
            .::.:|....|:.|:::|:||.::|.|:  :.::.: |:|:   .:|....|.......|.:...
  Fly   141 FVETFLDDHDFVAGDQLTIADFSIVSTITSIGVFLE-LDPA---KYPKIAAWLERLKELPYYEEA 201

Human   204 LGEVKLCEKMAQFDAKKFAETQPKKD 229
            .|:          .|.:|.|....|:
  Fly   202 NGK----------GAAQFVELLRSKN 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EEF1G	NP_001395.1	GST_N_EF1Bgamma	4..82	CDD:239342	19/61 (31%)
		GST_C_EF1Bgamma_like	91..213	CDD:198290	24/132 (18%)
		tolA	<212..>278	CDD:236545	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..268		3/9 (33%)
		EF1G	277..381	CDD:395522
GstE4	NP_611326.1	GST_N_Delta_Epsilon	4..77	CDD:239343	18/55 (33%)
		GstA	6..196	CDD:223698	43/188 (23%)
		GST_C_Delta_Epsilon	91..209	CDD:198287	25/141 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810