DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif20a and pav

DIOPT Version :9

Sequence 1:	NP_001159878.1	Gene:	Kif20a / 19348	MGIID:	1201682	Length:	887	Species:	Mus musculus
Sequence 2:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster

Alignment Length:	948	Identity:	243/948 - (25%)
Similarity:	399/948 - (42%)	Gaps:	212/948 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    52 DKQALLEDTSEK----VKVYLRIRPFLTSELDRQEDQGCVCIENTETLVLQAPKDSFALKSNERG 112
            :||.  .|||:|    |.|:.|:||     |....|...:.::|:.|:.|. |:|..........
  Fly    23 EKQR--RDTSDKARDPVNVFCRVRP-----LQSDADLTSLRVKNSTTIALN-PQDQLLQHHKPHN 79

Mouse   113 VGQATHKFTFSQIFGPEVGQVAFFNLTMKEMVKDVLKGQNWLIYTYGVTNSGKTYTIQGTSKDAG 177
            ..|...::.|..:|.|:..|...:....:.:|:::|||:|.|::|||||.||||||:.|..:..|
  Fly    80 GAQREVQYIFKHVFQPDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLRHRG 144

Mouse   178 ILPQSLALIFNSLQGQLHPTPDLKP-------LLSNEVIWLDSKQIRQEEMKKLSLLIGGLQEEE 235
            |:|:.|.::|.::..........||       :||.|    |:...||.||.:
  Fly   145 IMPRCLDVLFRTISDYQAKKFVFKPDKLNGFEILSEE----DALLERQHEMNQ------------ 193

Mouse   236 LSTSVKKRVHTESRIGASNSFDSGVAGLSSTSQFTSSSQLDETSQLWAQPDTVPV---SVPADIR 297
                         |...|..|              :....|...::.:|....|:   .:..|..
  Fly   194 -------------RFAGSGRF--------------AFRHKDSDPEIASQASVEPIPLLGLDEDNM 231

Mouse   298 FSVWISFFEIYNELLYDLLEPPSHQHKRQTLRLCEDQNGNPYVKDLNWIHVRDVEEAWKLLKVGR 362
            :||::::.||||..:|||||....|...|:..:.||.|.:.:|..:..:.|:.||:|.::.::|:
  Fly   232 YSVFVTYIEIYNNSVYDLLEDSGIQKTLQSKIIREDANRHMFVHGVTEVEVKTVEDALEVFQMGQ 296

Mouse   363 KNQSFASTHMNQQSSRSHSIFSIRILHL----QGEGDIVPK----ISELSLCDLAGSERCKHQK- 418
            |.:....|.:|.:||||||:|:||::..    |||..:..:    :|:|||.|||||||....|
  Fly   297 KRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLVDLAGSERSSRTKN 361

Mouse   419 SGERLKEAGNINTSLHTLGRCIAALRQNQ---QNRSKQNLIPFRDSKLTRVFQGFFTGRGRSCMI 480
            :|.||:||||||.||.||..|:..||:||   .|......:|:||||:|.:|:.:|.|.|:..||
  Fly   362 TGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMFKNYFDGEGQVSMI 426

Mouse   481 VNVNPCASTYDETLHAAKFSALAS--QLVHAPPVHLGIPSLHSFIKKHSPQVGPGLEKEDK---- 539
            |.:||....|||.:...||:.:..  |:..|.|:            |....:.||..|.:|
  Fly   427 VCINPRIEDYDENMQVMKFAEMTQEVQIARATPM------------KQDLGLTPGRRKANKLFKI 479

Mouse   540 -----------ADSDLE------------------DSPEDEADVSVYGKEELL----QVVEAMKA 571
                       ...|||                  ||||.:..:     .||:    |.:|..|.
  Fly   480 AVNNLNELGIPEAKDLEVDVGLVYSLGPDFPAYEMDSPEAQIKI-----RELMHYLEQRIEKRKK 539

Mouse   572 LLL-------KERQEKLQLE---IQLREEICNEMVEQMQQREQWCSERLDNQKELMEELYEEKLK 626
            |..       ..||..:.|:   :|||.|:.:......|:|::  |..|:.:    ..::|..:.
  Fly   540 LRANLDIKCDSFRQMLMNLDRDNLQLRTELASLKAVYKQERDR--SAALEKK----VRIHESSID 598

Mouse   627 ILKESLTTFYQEQIQERDEKIEELETLLQEAKQQPAAQQSGGLSLLRRSQRLAASASTQQFQEVK 691
            :|..:|:. .:.||:|...|:.|.|.:|.:.:.:...|:.      :.|.:||.. |.:..:|.:
  Fly   599 VLNNTLSK-QERQIEELTFKLNEKENMLTQKEHEKEKQKK------KFSSKLAVE-SDKNKREFE 655

Mouse   692 AELEQCKTELSS----TTAELHKYQQVLKPPP-PAKPFTIDVDKKLEEGQKNIRLLRTELQKLGQ 751
            .:|.:.:.:|..    ...:|.....:|:... |:.|.:...:..|.|..:.....|||     :
  Fly   656 LKLREQRVKLQERMRIKDEKLRLVSNILQSEDLPSLPRSQSSENILNEKDRGAYTARTE-----E 715

Mouse   752 SLQSAERACCHST------GAGKLRQALTNCDDILIKQNQ-------TLAE--LQNNMVLVKL-D 800
            |...|.|...::|      .|....:...:..|..::...       |:.:  |:|...:.|| |
  Fly   716 SSVPATRTDIYATPRHGAAAANNRHRRSRSAGDKWLEHRAANPVPLGTIMQPYLKNRKSVTKLTD 780

Mouse   801 LQKKAACIAEQYHTVLK---LQGQASAKKRLG-------------ANQ----ENQQPNHQPPGKK 845
            |::..|....:|..|.:   ..|....|...|             .|.    :.:.|.|.|..|:
  Fly   781 LKELTAHGTTKYCLVSQDADTDGDVETKLYKGNVIPTCGGGAQVVFNDVECLKQKSPVHSPTRKR 845

Mouse   846 PFLRNL-------LPRTPTCQSSTDSSPYARILRSRHS 876
            |...|:       :|.|.|  |:.|.:....:....||
  Fly   846 PSNGNISALGGGAVPSTVT--SAQDVASRCNLGIEGHS 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif20a	NP_001159878.1	KISc_KIF23_like	62..504	CDD:276819	146/467 (31%)
		Kinesin	69..505	CDD:278646	143/459 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	527..553		11/58 (19%)
		GBP_C	<536..651	CDD:303769	34/161 (21%)
		coiled coil	620..631	CDD:293879	2/10 (20%)
		coiled coil	640..651	CDD:293879	4/10 (40%)
		Globular. /evidence=ECO:0000255	805..887		20/99 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	826..875		13/72 (18%)
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	145/463 (31%)
		Kinesin	42..452	CDD:278646	143/458 (31%)
		MKLP1_Arf_bdg	735..837	CDD:293148	16/101 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0247
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R641
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850