DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex2 and Pex2

DIOPT Version :9

Sequence 1:	NP_001156773.1	Gene:	Pex2 / 19302	MGIID:	107486	Length:	305	Species:	Mus musculus
Sequence 2:	NP_648210.1	Gene:	Pex2 / 38941	FlyBaseID:	FBgn0035876	Length:	281	Species:	Drosophila melanogaster

Alignment Length:	304	Identity:	90/304 - (29%)
Similarity:	150/304 - (49%)	Gaps:	38/304 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 MQSANRVLRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKAFLWLFLWRFTIYSK 72
            |:....|.|::|:||:.|||.:.:|:.....:......|.|..:.:||:...:...:|..::..:
  Fly     1 MEKNKYVPRVNQIDAIYLNKDIARLIRDNLLENLQAISPVLFIKIQPELDLIIQSAIWFGSVGKR 65

Mouse    73 NATVGQSVLNIQYKND--SSLNLIYQPPSKTQKLWYAVCTIGG---KWLEERCYDLFRNRHLASF 132
            .:|.||.:|.:.|..:  :...|:         |.:.:..:.|   .|.|.|.     .|.:..|
  Fly    66 CSTFGQQLLVLAYDAEKLTVSRLV---------LHFILTVLPGYVKSWEERRL-----TRRVEWF 116

Mouse   133 GKAKQFMNFLVGLLKLGELINFLIFLQKGKFATLTERLLGIHSVFCKPQNMREVGFEYMNRELLW 197
            .:|..::.....:|   .::|:..||:.|:..||.:.|||:..:..:....|::|::|:.|||||
  Fly   117 SEAIMWVENSALIL---NILNYFRFLKTGRKPTLVDYLLGLDYISLRNNQRRDIGYKYLTRELLW 178

Mouse   198 HGFAEFLIFLLPLINIQKLKAKLSSWCIPLTGAAGHDS--------TLGSSGKECALCGEWPTMP 254
            .||.|.|..:||:||.:||:..|.||..........|.        ||.::   |..|||.||:|
  Fly   179 GGFMEILGLVLPIINFRKLQRVLKSWTFSGRRLEDRDGPAFLAPQMTLSTT---CTFCGERPTLP 240

Mouse   255 HTIGCEHVFCYYCVKSSFLFDIYFTCPKCGTEVHSVQPLKSGIE 298
            |.:||.|::||||:.::.|.|..|.||.||    |..| :|||:
  Fly   241 HHMGCGHIYCYYCLNANVLTDASFCCPNCG----SACP-ESGIQ 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex2	NP_001156773.1	Pex2_Pex12	27..224	CDD:398431	51/201 (25%)
Pex2	NP_001156773.1	RING-HC_PEX2	243..284	CDD:319440	20/40 (50%)
Pex2	NP_648210.1	Pex2_Pex12	22..207	CDD:282595	46/189 (24%)
Pex2	NP_648210.1	RING	230..269	CDD:214546	17/38 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849083
Domainoid	1	1.000	76	1.000	Domainoid score	I8992
eggNOG	1	0.900	-	-		E1_KOG2879
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H269
Inparanoid	1	1.050	140	1.000	Inparanoid score	I4492
Isobase	1	0.950	-	0.721928	Normalized mean entropy	S4319
OMA	1	1.010	-	-		QHG53949
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005881
OrthoInspector	1	1.000	-	-		oto94256
orthoMCL	1	0.900	-	-		OOG6_103635
Panther	1	1.100	-	-	LDO	PTHR23350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5623
SonicParanoid	1	1.000	-	-		X5660
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740