DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Igdcc3 and fra

DIOPT Version :9

Sequence 1:	NP_001344186.1	Gene:	Igdcc3 / 19289	MGIID:	1202390	Length:	813	Species:	Mus musculus
Sequence 2:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster

Alignment Length:	1054	Identity:	217/1054 - (20%)
Similarity:	323/1054 - (30%)	Gaps:	424/1054 - (40%)

- Green bases have known domain annotations that are detailed below.

Mouse    32 LLLLLLLLPLPAPSLGLGHSAELAFSVEPNDDIANPGQPIVLGC----------KVEGTPPVQVS 86
            ||...|:..|...||.   |..|:|::||.|.:...|..::|.|          |.:...|..||
  Fly    16 LLSSCLIFQLIGSSLA---SQALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVS 77

Mouse    87 WRKNGAELPEG--------THTTLLANGSLLIHHFRLEQGGSPSDEGDYEC-VAQNRFGLLVSRK 142
            .|..|   |:|        |..|.|.||||.|......:|.:    |.|:| :.....|.::||.
  Fly    78 IRWRG---PDGQDLVIVGDTFRTQLKNGSLYISSVEENRGLT----GAYQCLLTAEGVGSILSRP 135

Mouse   143 ARLQAATMSDFHVHPQAVTGEEGGVARFQCQI------HGLPKPLITWEKNRVPIDTDDERYTLL 201
            |.:......|.:..........|..|.|:|.:      .|: |..:.|.|:.:|:..|..|..:|
  Fly   136 ALVAIVRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGV-KHSVQWLKDDLPLPLDKLRMVVL 199

Mouse   202 PKGVLQITGLRAEDSGIFHCVASNIASVRVSHGARLTV---SGSGSGTYKEPTILVGPENLTLTV 263
            |.|.|:|..:...|.|.:.|..::.:|.|:|....|.:   |..|:.....|:.||||...|:..
  Fly   200 PNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVRE 264

Mouse   264 HQTAVLECVATGNPRPIVSWSR---------LDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVC 319
            ..|..|:|||.|.|:|.:.|.|         ||.|      ..::|||:|.||......||.|.|
  Fly   265 GDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSR------FSIVGTGSLQISSAEDIDSGNYQC 323

Mouse   320 AANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGA 384
            .|:  .|.....||..:.||.|.:|::.|:..:..........|...|:|.|.:.|||||.::..
  Fly   324 RAS--NTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITP 386

Mouse   385 GGHVRLKNNNSTLSISGVGPEDEAIYQCVAENIAGSSQASARLTVL------------------- 430
            ..:::|.:.:: |.|.|:...|..::|||..|.|||..|:|||.|:
  Fly   387 NDYMQLVDGHN-LKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSL 450

Mouse   431 ----------------------------------------------------------------- 430

  Fly   451 QTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRF 515

Mouse   431 ---------------------------------------------------WAEG---------- 434
                                                               |.:.
  Fly   516 NILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQ 580

Mouse   435 -----------------------------LPGPPRNVRAVSVSSTEVRVSWSEPLAHTKEIIGYV 470
                                         ||..||::.|..|.|..|.:||.|||.:..:::.|.
  Fly   581 SPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYT 645

Mouse   471 LH------------IRKAADSPKLEYQEAVSKSTFQHLVR------------------------- 498
            ::            :.|:.|..::..|..:...|:|..|.
  Fly   646 VYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIA 710

Mouse   499 ----------------------------------------------------------DLEPSTA 505
                                                                      :|.|.|.
  Fly   711 GPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRPHTD 775

Mouse   506 YSFYIKAYTPRGASLASVPTLASTLGEAPVPPPLSVRL--LGSSSLQLLWKPWPRLAQHNG---G 565
            |...:..:...|...:|......|....|..||.:|.|  ..|||:.:.|:| |.....||   |
  Fly   776 YVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEP-PAEEDRNGQITG 839

Mouse   566 FKLFYR------PVSATSFTGPILLPGTVSSYNLSQLDPSTVYEVKLLAYNQHGDGNATVRFVSL 624
            :|:.||      .|.:|        |..:..:.||.||.:..|:||:.|...:|.|    .|...
  Fly   840 YKIRYRKFKDAPQVKST--------PANIRYFELSNLDRNAEYQVKIAAMTVNGSG----PFTEW 892

Mouse   625 KGASERTALTPPCDCRKEDVTNHTSTTG--IVIGIHIGVTCIIFCVLFLLFGQRGRVLLCKDVEN 687
            ..|:           ..|:..:.|...|  |.|.||.|...|.     |.:|
  Fly   893 NRAN-----------TLENDLDETQVPGKPIWISIHPGANNIA-----LHWG------------- 928

Mouse   688 QLSPPQGP------------RSQRDPGILALNGLSR-----------------------GEGGQL 717
               |||.|            |...|...:.|....|                       |:|..:
  Fly   929 ---PPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPI 990

Mouse   718 -----SRDEKPVDA 726
                 :|||:||||
  Fly   991 YDNIKTRDEEPVDA 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Igdcc3	NP_001344186.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Ig	56..147	CDD:325142	31/109 (28%)
		Ig	158..239	CDD:325142	23/86 (27%)
		Ig_3	250..321	CDD:316449	29/79 (37%)
		I-set	343..429	CDD:254352	27/85 (32%)
		FN3	436..529	CDD:238020	25/187 (13%)
		fn3	<556..615	CDD:306538	19/67 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..724		13/74 (18%)
		DNA_pol3_gamma3	<690..>812	CDD:331207	17/77 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	775..813
fra	NP_523716.2	Ig	36..140	CDD:299845	31/110 (28%)
		Ig	<180..222	CDD:299845	13/41 (32%)
		IG_like	257..340	CDD:214653	29/90 (32%)
		IGc2	264..327	CDD:197706	24/70 (34%)
		I-set	344..430	CDD:254352	27/86 (31%)
		Ig	363..428	CDD:299845	23/65 (35%)
		FN3	611..703	CDD:238020	19/91 (21%)
		FN3	711..799	CDD:238020	6/87 (7%)
		FN3	806..897	CDD:238020	31/114 (27%)
		FN3	908..989	CDD:238020	19/101 (19%)
		FN3	1011..1097	CDD:238020
		FN3	1109..1205	CDD:238020
		Neogenin_C	1273..1521	CDD:284094
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910