DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptprz1 and Lar

DIOPT Version :9

Sequence 1:XP_006505075.1 Gene:Ptprz1 / 19283 MGIID:97816 Length:2318 Species:Mus musculus
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:2300 Identity:526/2300 - (22%)
Similarity:827/2300 - (35%) Gaps:750/2300 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse   180 SILFEVGVEENLDYKAIIDGTESVSRFGKQAALDPFVLQNLLPNSTDKYYIYNGSLTSPPCTDTV 244
            ::|..:.::|:.:|..|     :.|..|:..::....:|: ||.:.....|...:.||.    .:
  Fly   286 NVLQLINIQESANYTCI-----AASTLGQIDSVSVVKVQS-LPTAPTDVQISEVTATSV----RL 340

Mouse   245 EW------------IVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVF 297
            ||            |.:|     .::....|.|:     ||.:.:...::......:|:|.....
  Fly   341 EWSYKGPEDLQYYVIQYK-----PKNANQAFSEI-----SGIITMYYVVRALSPYTEYEFYVIAV 395

Mouse   298 SSY------------TGKEEIHEVVCSSEPENVQADPENYTSLLVTWERPRVVYDAMIEKFAVLY 350
            ::.            ||..........|.|.|||....:.:::::|||.|... :..:..:.|.|
  Fly   396 NNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETP-NGQVTGYKVYY 459

Mouse   351 -----QPLAG-NDQA--KHEFLTDGYQDLGAILNNLLPNMSYVLQIVAVCSNGLYGKYS------ 401
                 ||.|. |.|.  ..|..|         ::.|.|:..|.:::.|..|.|. |..|      
  Fly   460 TTNSNQPEASWNSQMVDNSELTT---------VSELTPHAIYTVRVQAYTSMGA-GPMSTPVQVK 514

Mouse   402 -DQLIVDMPTEDAELDLFPELI---------GTEEIIKEEEYGKDNEEDTGLNPGRDSVTNQIRK 456
             .|.:...|:.....|:....:         .:|.|:..|.|            ..|:..||...
  Fly   515 AQQGVPSQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELY------------WNDTYANQAHH 567

Mouse   457 KEPQVSTTTHYNHMG----TKYNEAKTNRSPTRGSEFSGKSDVPNTSPNSTSQHVAEFETERGIS 517
            |  ::|.:..|...|    |.|......|| .||   .|.:..|  .|..|.|:.|         
  Fly   568 K--RISNSEAYTLDGLYPDTLYYIWLAARS-QRG---EGATTPP--IPVRTKQYGA--------- 615

Mouse   518 LPSQTGTNLPPHNVEGTSASLNSGSKTLFIFPQMNLSGTAESLNTVP---------ITEYKEVSA 573
                     ||.|:...:.                 |.|..||:.:|         |..||....
  Fly   616 ---------PPRNITAIAT-----------------SSTTISLSWLPPPVERSNGRIIYYKVFFV 654

Mouse   574 DVSEEENFL------------------TDFKLDTGADDSSGSSPSTSTVPFSSDNLSHGYI--TS 618
            :|..|::..                  |::|:...|..|.|..|.           ||..|  |.
  Fly   655 EVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPR-----------SHPIILRTQ 708

Mouse   619 SDMPEAITYDVLKPGSTRNAPEDSAPSGSEESLKDPSLEGSVWFPGSTDLTTQS--ETGSG--RE 679
            .|:|.       .|...:..|.:|  :....|.|.|..:..........:..|.  :.|.|  .|
  Fly   709 EDVPG-------DPQDVKATPLNS--TSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNE 764

Mouse   680 SF-------LQVNSTDIQIDESRETTESFSPDATVS-QDPSVTDMGMPHYSTFAYLPTEVTPQAF 736
            .|       |:.|.|.:|            ||...| |..::|..|....|....:.        
  Fly   765 PFKFDVVDTLEFNVTGLQ------------PDTKYSIQVAALTRKGDGDRSAAIVVK-------- 809

Mouse   737 TPSSRPLDLAPTINILHSQTTQPVYN----GETPLQ----------------PSYSSEVF--PLA 779
            ||...|  :.||:: |.....:|:.:    .|.|.|                .:...|:.  |..
  Fly   810 TPGGVP--VRPTVS-LKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQM 871

Mouse   780 TPLLLDNQTLNTT---PAASSSDSALHATPVSPSVGVSFES--ILSSYDDAPLLPFSSASFSSEM 839
            |....||......   ..|.|:           .:|:..|:  |..:.:..|..|.|:.      
  Fly   872 TKKRFDNLERGVEYEFRVAGSN-----------HIGIGQETVKIFQTPEGTPGGPPSNI------ 919

Mouse   840 FRHLHTVSQTLPQVTSAAERDELSLHASLLVARGDLLLEPSLVQYSDVASHQATTRAASDTLGFG 904
                 |:....|.|...........|.:.::.|.|       ||:.....|           |.|
  Fly   920 -----TIRFQTPDVLCVTWDPPTREHRNGIITRYD-------VQFHKKIDH-----------GLG 961

Mouse   905 SESAVFYKTSMVSQIESPRSDVVMHAYSSGPEPSYTVEGSHHVPTVSYSSAMPLHGSVDVSDQGS 969
            ||..:..:.::.:.:|. .::.:...      .:||.:|           |.|....:.|..:..
  Fly   962 SERNMTLRKAVFTNLEE-NTEYIFRV------RAYTKQG-----------AGPFSDKLIVETERD 1008

Mouse   970 LLINPSHISMPESSFITPTASLLQPPPALSGDGEWSGASSDSELL----------LPDADGLRTL 1024
            :...|  :|:...:....||.:.           |...:|..:||          :.|.|..:|.
  Fly  1009 MGRAP--MSLQAEATSEQTAEIW-----------WEPVTSRGKLLGYKIFYTMTAVEDLDDWQTK 1060

Mouse  1025 NI-----SSPVSVAEFT-YTTSV---FADGIKPLSKSEMMYGNETELKMSSFSDMAYPSKSTVVP 1080
            .:     :..|::.:|. |..::   |.:|:..||:                       |.||..
  Fly  1061 TVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSE-----------------------KVTVRI 1102

Mouse  1081 KMSDV----------VH----KWSESLKETSVSISSMKSVFPESLVYPTTKGFEQGVSHVP--EI 1129
            |..||          .|    .||..::.|.|   :.|..|....|:..::||.| ...||  ||
  Fly  1103 KPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPV---NYKISFDAMKVFVDSQGFSQ-TQIVPKREI 1163

Mouse  1130 IFP-VQPTHTASQASGDTWLKPGLSANSEAAFSDTASREVVHPSTQPLLYEAATPFNTEALLQPS 1193
            |.. ...|||.::.|..|    ..:.|..|..||.:.|.   |:...:..:.|.|   :.:::|.
  Fly  1164 ILKHYVKTHTINELSPFT----TYNVNVSAIPSDYSYRP---PTKITVTTQMAAP---QPMVKPD 1218

Mouse  1194 FQASDVDTLLKTALPSVPSDPILAGTPQVEQSSSSVSHPMASESGSSESMLHFTSVPILDISPSK 1258
            |..            .|..:.||...||..:....:||            .:...||   ...|.
  Fly  1219 FYG------------VVNGEEILVILPQASEEYGPISH------------YYLVVVP---EDKSN 1256

Mouse  1259 VHSTPLQGLT---VPHSSK-KFSEQGLLKSKSPQQVLPSLF---SNDEF--FQSAHLDVSQAYPP 1314
            :|..|.|.||   :|..:| :......:.:|.||:.:|..|   |.|::  |.:..|:..:.|  
  Fly  1257 LHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRY-- 1319

Mouse  1315 KGRHAFVTPVLSIDEPQNTLINKLVYSEDIFSSTEISITDKVLTGLPTLASDVLSSTDHSVPLGS 1379
               ..||..|  :|.||     |.:|:...|                   |:.||......|.|.
  Fly  1320 ---RIFVRAV--VDTPQ-----KHLYTSSPF-------------------SEFLSLDMREAPPGE 1355

Mouse  1380 GP-------ISLTMVSPNRD-DSVTTAKLLLPSTATSKLTQSARSDADLVGGGEDGDDYDDDDYD 1436
            .|       .:...||.||: |......::||...::.:..:|     |:               
  Fly  1356 RPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTA-----LI--------------- 1400

Mouse  1437 DIDRGRFPVNKCMSCLPYRESREKVMNDSDTQESSLVDQSDPISPLLFENTEEENGGTGVTRVDK 1501
                        :.|:..|.          .|.....||:....||:                  
  Fly  1401 ------------VLCVVKRR----------RQPCKTPDQAAVTRPLM------------------ 1425

Mouse  1502 SPPPSMLPQNHNDGKEDSDIQMGSAVLPHTPGSKAWAVLTSDEESGSGQGTSDSLNDNETSTDFS 1566
                            .:|:                         |:|...||.::..       
  Fly  1426 ----------------AADL-------------------------GAGPTPSDPVDMR------- 1442

Mouse  1567 FPDVNEKDTDGVLETDDTGIAPGSPRSSTPSVTSGHSGVSNSSEAEASNSSHESRIGLAEGLESE 1631
                                                                             
  Fly  1443 ----------------------------------------------------------------- 1442

Mouse  1632 KKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDNTSPRVISTPPTPIFPISDDIGAI 1696
                                        |..|||          |.:||.||            |
  Fly  1443 ----------------------------RLNFQT----------PGMISHPP------------I 1457

Mouse  1697 PIKHFPKHVADLHASNG--FTEEFETLKEFYQEVQSCTADLGITADSSNHPDNKHKNRYVNIVAY 1759
            ||..|..|:..|.:::.  |::|:|:::...|          .|.|:||...||.||||.|:.||
  Fly  1458 PISEFANHIERLKSNDNQKFSQEYESIEPGQQ----------FTWDNSNLEHNKSKNRYANVTAY 1512

Mouse  1760 DHSRVKLTQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMIT 1824
            |||||:|..:....|  :|||||||.|||.:..||:|.||||:.|..|||||.||.....|||:|
  Fly  1513 DHSRVQLPAVEGVVG--SDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMT 1575

Mouse  1825 NLVEKGRRKCDQYWPTDGSEEYGSFLVNQKSVQVLAYYTVRNFTLRNTKLKKLSELFQGSQKGRS 1889
            .|.|:.|.||||||||.|:|.||...|.....|.||.|::|.|.|              .::|.:
  Fly  1576 RLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQL--------------CRQGFN 1626

Mouse  1890 SGRLVTQYHYTQWPDMGVPEYSLPVLAFVRKAAQAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQ 1954
            ..|.:.|..:|.|||.|||::..|.|.|:|:.........|||:|||||||||||.|||:||||:
  Fly  1627 DRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLE 1691

Mouse  1955 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVPDSHIHSYVNTLLIPG 2019
            :::||..::|:|.:..:|:||||:||||:||:||||.::|||:...||||..::|:::..|||..
  Fly  1692 RMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITE 1756

Mouse  2020 PTGKT--KLEKQFQLLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYI 2081
            | |:|  .:|.:|:.||...:..|.:.||...||:.|||...|:|.|.|||.::.:.| ||:||:
  Fly  1757 P-GETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYV 1820

Mouse  2082 NASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPI 2145
            |||:|.||...:.:|..|.|:....:|||||:|:||:.:|||:...:.|..:: |.|||: :..:
  Fly  1821 NASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPH-ERSV 1884

Mouse  2146 NCESFKVTLMSEEHKCLSNEEKLIVQDFILEATQDDYVLEVRHFQCPKWPNPDSP---------- 2200
            ..:.:.|..::|     .|..:..:::|.:...:|.....||.||...||....|          
  Fly  1885 RYQYYVVDPIAE-----YNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFI 1944

Mouse  2201 --ISKTFELISIIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENAMDVYQVAKMINL 2263
              :.||        :|...:|||:.||...|...:|.|..|:.::.:::.|..:||:|..:::..
  Fly  1945 GQVHKT--------KEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRS 2001

Mouse  2264 MRPGVFTDIEQYQFLYKVVLSLVST 2288
            .||.:....:||.|.|:..|..:.:
  Fly  2002 QRPAMVQTEDQYHFCYRAALEYLGS 2026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptprz1XP_006505075.1 alpha_CARP_receptor_like 45..298 CDD:239396 22/129 (17%)
fn3 313..395 CDD:365830 23/89 (26%)
PTP_DSP_cys 1714..1997 CDD:391942 132/282 (47%)
R-PTP-Z-2 2080..2283 CDD:350507 60/215 (28%)
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352 6/36 (17%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 6/35 (17%)
fn3 324..404 CDD:278470 13/93 (14%)
FN3 423..514 CDD:238020 26/101 (26%)
FN3 520..610 CDD:238020 22/109 (20%)
FN3 616..707 CDD:238020 22/118 (19%)
FN3 712..810 CDD:238020 23/126 (18%)
FN3 832..907 CDD:238020 13/85 (15%)
FN3 914..1005 CDD:238020 22/137 (16%)
FN3 1012..1101 CDD:238020 20/124 (16%)
fn3 1106..1198 CDD:278470 27/99 (27%)
PTPc 1476..1731 CDD:214550 130/280 (46%)
PTPc 1503..1731 CDD:238006 120/243 (49%)
PTPc 1763..2022 CDD:214550 82/272 (30%)
PTPc 1791..2022 CDD:238006 73/244 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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