DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptprm and CG42327

DIOPT Version :9

Sequence 1:	NP_001344554.1	Gene:	Ptprm / 19274	MGIID:	102694	Length:	1486	Species:	Mus musculus
Sequence 2:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster

Alignment Length:	1329	Identity:	266/1329 - (20%)
Similarity:	448/1329 - (33%)	Gaps:	370/1329 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    55 TKPTSDPWMPSGSFMLVNTSGKPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNAAPGLLNVYVK 119
            |..||.| :|:.:....:.....|...:...:.||.|....      |:|..|..|..|
  Fly   294 TTSTSTP-LPTTAVSFASNENVIEESTSKSEVRQLPEKRAK------FISENSTNAQQL------ 345

Mouse   120 VNNGPLGNPIWNISGDPTRTWHRAELAISTFWP--NFYQVIFEV-----VTSGHQGYLAIDEVKV 177
              ..|....:|:::|  .:...:|.|..:|..|  |...:..::     .|..|:....:|.:.:
  Fly   346 --TLPNTAEVWSLAG--MKAVPKAPLTTTTSVPLLNHTDLANDIDMPLNKTELHKEKNLLDWMNI 406

Mouse   178 LGHPCT---RTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSR 239
            ...|.|   ||...:|   ..::|.:.||   .|....:..:......|.|   .|::..||::|
  Fly   407 AMLPLTPENRTEFVVR---TTLDATEGAT---QATTEALVEETHSKSDITV---GLEQDNVTTAR 462

Mouse   240 RFIAS-------FNVVNTTKR-------------DAGKYRCMIC-------TEGGVGISNYAELV 277
            ...::       .|:..||.|             ||...:.:..       ||.....:.:..|
  Fly   463 TMPSTPDPGSMDLNMTTTTVRTQQLEVPLVKKMSDAANAKLIEAVTEPQRETEAATEAATFVTL- 526

Mouse   278 VKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTS----- 337
                     |.:||:.|.|..........:|......|.|....:.:.|.:....:.||:
  Fly   527 ---------PEKLATFGITARVDSTQTELLNVTTAAAATESGEMSKANSTDTLSAMTSTTTTTAR 582

Mouse   338 -YKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWE 401
             ..:.|:.|:.:.|.:..|.......:|:...|..:.|..|.|           |.|...|....
  Fly   583 PMSVEHVTPEQDMEAATSLATTAATSSGTTEAAATSSTTAATP-----------VVSEAATAAEA 636

Mouse   402 PFGYNVTRCHSYNL------TVHYGYQVGGQEQVREEVSWDTDNSHPQHTITNLSPYTNVSVKLI 460
            ......|...:.::      |.....:......:|::   :.|||:.....|...|.:..:....
  Fly   637 SATSEATTAATLSVATTAASTTEIAMKATQISNIRDD---NDDNSNDVIVATTKFPESEQAATTA 698

Mouse   461 LMNPEGRKESQELTVQTDEDLPGAVPTESIQGSAFEEKIF------LQWREPTQT-----YGVIT 514
            .:.|    .:..::|:...::..::..|.|..|.....|.      .....||||     ...:.
  Fly   699 SVEP----TTTSVSVRVAGEVSTSIRPEIIVTSTRNSTIVDTSTSATSVATPTQTEIAQISNEVN 759

Mouse   515 LYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQF 579
            |..:|.|.........:|.......:.:.|..         ..|.|.....:||....|..||..
  Fly   760 LEAVTVKTRDGLSDTNELRTAEKTDNAVNNSV---------AITESDLGALATAVETNPTTTNSL 815

Mouse   580 TTKISAPSMPAYEFETPLNQTDN-------------TVTVMLKPAQSRGAPVSV----------- 620
            .:.:|..|.   |.|:.| :|:|             ..||.:...:|..||.:.
  Fly   816 LSDVSKLSK---EHESSL-ETNNIGEAPPESTTPAAPATVAVATDESTAAPAATGGQEIVREGQH 876

Mouse   621 ---YQIVVEEERPRRTKKTTEILKCYPVPIHFQNASILNSQYYFAAEFP--ADSLQAAQPFTIGD 680
               .|:..|::..::..|||..:............|...:    ..|.|  ..::|..:...:.|
  Fly   877 HDGQQVADEQDTEQQLAKTTMAVTTTTTSATTTTTSTTTT----TTETPLTTTTMQPVEISLLDD 937

Mouse   681 NKTYNGYWNTPLLPHKSYRIYYQAASRANGETKIDCVRVATKAAIIVTQLTTPYIRIAPAAGDGQ 745
            :.|..  ..||..|     :|:::               :|.|:..:...||    :.|     :
  Fly   938 STTTT--TTTPAPP-----VYFES---------------STVASTTIRSSTT----MLP-----E 971

Mouse   746 LTGAVTPKP--------VPEPEKQTDH------------------TVKIAGVIAGILLFVIIFLG 784
            .|.|.|..|        .|.| .:.||                  ||.:.||:|.|||...::|
  Fly   972 TTTASTQSPSEMPPTFMAPYP-NELDHMQTNAQDNGTDVNVIIAITVSVIGVVALILLVAFLYL- 1034

Mouse   785 VVLVMKKRKLAKKRKETMSSTR-QEMTVMVNSMDKSYAEQGTNCDEAFSFMGTHNLNGRSVSSPS 848
                     :.|::|:|....| :.:::...|:|.            .|.:|:....||.:.:.
  Fly  1035 ---------MRKRQKQTSYGQRCRPVSLDAYSLDN------------VSVLGSVRRKGRDMRAS- 1077

Mouse   849 SFTMKTNTLSTSVPNSYYPDPFVPTAILDETHTMASDTSSLAQPHTYKKREAADVPYQTGQLHPA 913
                     ..:..|:.:.||                  ||.                    |..
  Fly  1078 ---------KRTYGNAAFDDP------------------SLR--------------------HNL 1095

Mouse   914 IRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDE----NRMKNRYGNIIAYDHSRV 974
            :..::|.:.:           :...:.|.|.:..|...|:.||    ...||||.|:|....:||
  Fly  1096 LTASELARFV-----------ERRSDVFEEFRDVPQIIARADEVPPGCEDKNRYANVIPLPETRV 1149

Mouse   975 RLQMLEGDNNSDYINGNYIDG-YHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVG 1038
            .||....|:.::|||.||:.| ...||:|||.|.|::.|..|||||:|.:.:..||..|:|.|.|
  Fly  1150 VLQRQGDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSENG 1214

Mouse  1039 RVKCCKYWP-----DDTEIYKDIKVTLIDTELLAEYVIRTFAVEKRGIHEIREIRQFHFTGWPDH 1098
            ..:|.:|.|     |:...|.|.:|||...|:...|.|.|..:::....|.||:..:.:. ||:.
  Fly  1215 IERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWYK-WPEA 1278

Mouse  1099 GVPYHATGLLGFVRQVKSK---------------------------------------------- 1117
            |||.....::..:.:.:|.
  Fly  1279 GVPAEEAPIIAMLLEARSSLKSYSLEQANELREKSATLETSMDADGSKAEAGSTSSHEINGNISS 1343

Mouse  1118 ---SPPNAGPLVVHCSAGAGRTGCFIVIDIMLDMAER-EGVVDIYNCVRELRSRRVNMVQTEEQY 1178
               :....|||.||||.|.||||..|..|:.:...|. :..|||...|..:|..|.:.|||:|||
  Fly  1344 RSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAVQTKEQY 1408

Mouse  1179 VFIHDAILEACLCGDTSIPASQVRSLYYD 1207
            .||:..         .|:.|:::.:|..|
  Fly  1409 EFIYKV---------ASMYAAKITNLSND 1428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptprm	NP_001344554.1	MAM	22..182	CDD:214533	25/133 (19%)
		ig	192..274	CDD:278476	18/108 (17%)
		FN3	282..361	CDD:214495	15/84 (18%)
		FN3	383..467	CDD:214495	12/89 (13%)
		fn3	499..574	CDD:306538	14/85 (16%)
		PTPc	933..1187	CDD:214550	94/313 (30%)
		PTPc	1249..1481	CDD:238006
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	88/290 (30%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	88/290 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100