DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptpru and Lar

DIOPT Version :9

Sequence 1:XP_011248512.1 Gene:Ptpru / 19273 MGIID:1321151 Length:1473 Species:Mus musculus
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:1760 Identity:438/1760 - (24%)
Similarity:664/1760 - (37%) Gaps:520/1760 - (29%)


- Green bases have known domain annotations that are detailed below.


Mouse    59 WEQVRIHPGTRTPEDLPHG------AYLMVNASQHAPGQRAHII----FQTLSENDTHCVQFSYF 113
            ||          |.:.|:|      .|...|::|......:.::    ..|:||...|.:   |.
  Fly   442 WE----------PPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSELTPHAI---YT 493

Mouse   114 L----YSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALI 174
            :    |:..|..|.:..|.|:...|.....      |:.|.....|.||:..|           .
  Fly   494 VRVQAYTSMGAGPMSTPVQVKAQQGVPSQP------SNFRATDIGETAVTLQW-----------T 541

Mouse   175 SPDHKGYIGLDDILLFSYPCAKAPHFSRLGDVEV----NAGQNASFQCMAAGRAAEAEHFFLQRQ 235
            .|.|.....:...|.::...|...|..|:.:.|.    ....:..:....|.|:        ||.
  Fly   542 KPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARS--------QRG 598

Mouse   236 SGVLVPAAGVRHISH----RRFLA------TFPLA---------------------SVGRSEQDL 269
            .|...|...||...:    |...|      |..|:                     .|||.:.:.
  Fly   599 EGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEA 663

Mouse   270 --------------------YR-------CVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGP 307
                                |:       .|...||.      ..:|::........||.::|.|
  Fly   664 TTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRS------HPIILRTQEDVPGDPQDVKATP 722

Mouse   308 TYLIIQLNTNSI-IGDGPIVRKEIEYRMARGPWAEVHAVNLQ-------------------TYKL 352
                  ||:.|| :...|.:.|: ...:.||  ..:||..|:                   .:.:
  Fly   723 ------LNSTSIHVSWKPPLEKD-RNGIIRG--YHIHAQELRDEGKGFLNEPFKFDVVDTLEFNV 778

Mouse   353 WHLDPDTEYEISV-LLTRPGDGGTGRPGPPLISRTKCAEPTRAPKGLAFAEIQARQ----LTLQW 412
            ..|.|||:|.|.| .|||.|||..   ...::.:|....|.|....|   :|..|:    :.|:|
  Fly   779 TGLQPDTKYSIQVAALTRKGDGDR---SAAIVVKTPGGVPVRPTVSL---KIMEREPIVSIELEW 837

Mouse   413 EPLGYNVTRCHTYAVSLCYRYTLGGSHNQTIRECVKMERGASRYTIKNLLPFRNIHVRLILTNPE 477
            |      ....||.....||.. .|..:|.::|.:......::....||........|:..:|..
  Fly   838 E------RPAQTYGELRGYRLR-WGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHI 895

Mouse   478 GRKEGKEVTFQTDEDVPGGIAAE-SLTF-TPLEDMIFLKWEEP--QEPNGLITQYEISY-QSIES 537
            |..:.....|||.|..|||..:. ::.| ||  |::.:.|:.|  :..||:||:|::.: :.|:.
  Fly   896 GIGQETVKIFQTPEGTPGGPPSNITIRFQTP--DVLCVTWDPPTREHRNGIITRYDVQFHKKIDH 958

Mouse   538 SDPAVNVPGPRRTISKLRNETYH--VFSNLHPGTTYLFSVRART--------------------- 579
            .            :...||.|..  ||:||...|.|:|.|||.|                     
  Fly   959 G------------LGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGR 1011

Mouse   580 ----------------------------------------------------------------- 579
                                                                             
  Fly  1012 APMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKF 1076

Mouse   580 ----------------------------------------------------------------- 579
                                                                             
  Fly  1077 AQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFD 1141

Mouse   580 -------SKGFGQAAL-----------------------TEITTNISAPSFDYA----------- 603
                   |:||.|..:                       |....|:||...||:           
  Fly  1142 AMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTT 1206

Mouse   604 --DMPSPL----------GESENTITVLLRPAQGRGAPISVYQVVVEEERPRRLRREPGAQDCFS 656
              ..|.|:          ||.   |.|:|..|.....|||.|.:||..|....|.:.|   |.| 
  Fly  1207 QMAAPQPMVKPDFYGVVNGEE---ILVILPQASEEYGPISHYYLVVVPEDKSNLHKIP---DQF- 1264

Mouse   657 VPLTFETALARGLVHYFGAE-LAASSLLEAMPFT--VGDNQTYRGFWNPPLEPRKAYLIYFQAA- 717
              ||.:....|.......|. :||.....::|||  :|....|..|.|..||..|.|.|:.:|. 
  Fly  1265 --LTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFVRAVV 1327

Mouse   718 ----SHLKGETRLNCIRIARKAACKESKRP------------LEVSQRSEEMGLILGICAGGLAV 766
                .||...:..:.............:||            :.|::..:|..::..:....::.
  Fly  1328 DTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVST 1392

Mouse   767 LILLLGAIIVIIRKGRDRYAYSYYPKPVNMTKATVNYRQE-KTHMMSAVDRSFTDQSTLQEDERL 830
            .|:....|::.:.|.|                     ||. ||...:||.|...           
  Fly  1393 FIVSTALIVLCVVKRR---------------------RQPCKTPDQAAVTRPLM----------- 1425

Mouse   831 GLSFMDAPGYSPRGDQRSGGVTEASSL-LGGSPRRPCGRKGSPYHT-GQL-HPAVRVADLLQHIN 892
                                   |:.| .|.:|..|...:...:.| |.: ||.:.:::...||.
  Fly  1426 -----------------------AADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIE 1467

Mouse   893 QMKTAEGYGFKQEYESFFEG----WDATKKKDKLKGGRQEPVSAYDRHHVKLHPMLADPDADYIS 953
            ::|:.:...|.|||||...|    ||.:..:......|...|:|||...|:|..:.....:|||:
  Fly  1468 RLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYIN 1532

Mouse   954 ANYIDIRINRQGYHRSNHFIATQGDLAQGQAPSAPPGPKPEMIYDFWRMVWQEQCASIVMITKLV 1018
            |||.|      ||.:.|.::|||             ||..|...|||||.|:.:.|:|||:|:|.
  Fly  1533 ANYCD------GYRKHNAYVATQ-------------GPLQETFVDFWRMCWELKTATIVMMTRLE 1578

Mouse  1019 EVGRVKCSRYWP-EDSDMYGDIKITLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHG 1082
            |..|:||.:||| ..::.||.|.:|:.:|:.||.|.:|||.|.|:|::.|.|::|..|||||:||
  Fly  1579 ERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHG 1643

Mouse  1083 VPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTL 1147
            ||.|....|.|:||.:|.|||::||:::|||||.||||||||:|.||:..:.|.::|||..|..|
  Fly  1644 VPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCL 1708

Mouse  1148 CSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVNEFKATYREMIRIDPQSNSSQLREEFQTLNS 1212
            .::|..|:|||:||||||||||||.:||.|.:|........::::..:|....|.:..||:.|::
  Fly  1709 RAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSN 1773

Mouse  1213 VTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISSDG-DPNNYINAALTDSYTRSAAFIV 1276
            |  .:|..:...|.||.|:.|||.:.:||.:....:|....| :.::|:||:..|.|...:|:|.
  Fly  1774 V--KMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIA 1836

Mouse  1277 TLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFVSGTANE 1341
            ...|:|....||||:::::..|.:|||.:|.:.... .|.||||.....:|....|:.::.....
  Fly  1837 AQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGRE-KCFQYWPHERSVRYQYYVVDPIAEYNMP 1900

Mouse  1342 DLVSRVFRV----QNSSRLQEGHLLVRHFQFLRWSAYRDTPDSRKAFLHLLAEVDKWQAESG-DG 1401
            ....|.|:|    ..|||      .||.|||:.|.. :..|.|.:.|:..:.:|.|.:.:.| ||
  Fly  1901 QYKLREFKVTDARDGSSR------TVRQFQFIDWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDG 1958

Mouse  1402 RTVVHCLNGGGRSGTFCACATVLEMIRCHSLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1466
            ...|||..|.||||.|...:.|||.::...::|||...:.||:.:|.||:|.|||||||..||||
  Fly  1959 PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY 2023

Mouse  1467 LEALE 1471
            |.:.:
  Fly  2024 LGSFD 2028

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpruXP_011248512.1 MAM 31..194 CDD:214533 28/148 (19%)
IG 204..290 CDD:214652 20/147 (14%)
fn3 299..373 CDD:365830 26/94 (28%)
FN3 394..489 CDD:238020 19/98 (19%)
fn3 502..585 CDD:365830 29/246 (12%)
PTP_DSP_cys 951..1174 CDD:391942 110/223 (49%)
R-PTPc-U-2 1259..1465 CDD:350485 74/210 (35%)
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020 17/84 (20%)
FN3 520..610 CDD:238020 20/114 (18%)
FN3 616..707 CDD:238020 12/96 (13%)
FN3 712..810 CDD:238020 28/109 (26%)
FN3 832..907 CDD:238020 16/81 (20%)
FN3 914..1005 CDD:238020 27/104 (26%)
FN3 1012..1101 CDD:238020 0/88 (0%)
fn3 1106..1198 CDD:278470 10/91 (11%)
PTPc 1476..1731 CDD:214550 124/273 (45%)
PTPc 1503..1731 CDD:238006 115/246 (47%)
PTPc 1763..2022 CDD:214550 90/268 (34%)
PTPc 1791..2022 CDD:238006 81/238 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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