DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptprk and Lar

DIOPT Version :9

Sequence 1:XP_006512669.1 Gene:Ptprk / 19272 MGIID:103310 Length:1485 Species:Mus musculus
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:1797 Identity:484/1797 - (26%)
Similarity:720/1797 - (40%) Gaps:522/1797 - (29%)


- Green bases have known domain annotations that are detailed below.


Mouse    28 GQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQG---SYMVVDSSNHDPGEK 89
            |.||.||...:..|.......        :..|.....:.|||.|.|   .|.|..::|.:..|.
  Fly   412 GDFSFGGTKMESAPRNVQVRT--------LSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEA 468

Mouse    90 A-------RLQLPTMKENDTHCIDFSYLL----YSQKGLNPGTLNILVRVNKGPLANPIWNVTGF 143
            :       ..:|.|:.|...|.|   |.:    |:..|..|.:..:.|:..:|..:.|    :.|
  Fly   469 SWNSQMVDNSELTTVSELTPHAI---YTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQP----SNF 526

Mouse   144 TGRDWLRAELAVSTFW-----PNEYQVIFEA---EVSGGRSGYIAIDDIQVLS----YPCDKSPH 196
            ...|  ..|.||:..|     .:|..|.:|.   :....::.:..|.:.:..:    ||  .:.:
  Fly   527 RATD--IGETAVTLQWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYP--DTLY 587

Mouse   197 FLRLGDVEVNAGQNAT-----------------FQCIATGRDAVHNKLWL----QRRNGEDIPVA 240
            ::.|. .....|:.||                 ...|||....: :..||    :|.||      
  Fly   588 YIWLA-ARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTI-SLSWLPPPVERSNG------ 644

Mouse   241 QTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPT 305
              :.|.::.|     ..||.:.|         .|..:...|...:::.|..|           .|
  Fly   645 --RIIYYKVF-----FVEVGRED---------DEATTMTLNMTSIVLDELKR-----------WT 682

Mouse   306 YLLIQLNANSIIGDG----PIILKEVE-------------YRMTS--GSWT-------------- 337
            ...|.:.|.:.:|||    ||||:..|             ...||  .||.              
  Fly   683 EYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGY 747

Mouse   338 ETHA----------VNAP---------TYKLWHLDPDTEYEIRV-LLTRPGEGGTGLPGPPLITR 382
            ..||          :|.|         .:.:..|.|||:|.|:| .|||.|:|..   ...::.:
  Fly   748 HIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDR---SAAIVVK 809

Mouse   383 TKCAEPMRTPKTLKIAEIQ-ARRIAVDWES--------LGY------------------------ 414
            |....|:|...:|||.|.: ...|.::||.        .||                        
  Fly   810 TPGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKK 874

Mouse   415 ---NITRC--HTFNVTICYHYFRGHNESR------------------------ADCLDMDPKAPQ 450
               |:.|.  :.|.|....|...|....:                        ..|:..||...:
  Fly   875 RFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTRE 939

Mouse   451 H--------------VVNH-LPPYTNVSL-KMILTNPEGRKE----------------SEETIIQ 483
            |              .::| |....|::| |.:.||.|...|                |::.|::
  Fly   940 HRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVE 1004

Mouse   484 TDEDVPGPVPVKSLQGTSFENKIFLNWKEPLEPNGIITQYEVSY--SSIRSFDP----------- 535
            |:.|: |..|: |||..:...:....|.||:...|.:..|::.|  :::...|.           
  Fly  1005 TERDM-GRAPM-SLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLTES 1067

Mouse   536 ------------AVPVAG------------------PPQTVSNL-------------WNS----- 552
                        ||.:|.                  |.....||             |:.     
  Fly  1068 ADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLT 1132

Mouse   553 ---------------------------------THHVFMH----LHPGTTYQFFIRASTVK---G 577
                                             .|:|..|    |.|.|||.  :..|.:.   .
  Fly  1133 PVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYN--VNVSAIPSDYS 1195

Mouse   578 FGPATAINVTTNISAPS---LPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVV------ 633
            :.|.|.|.|||.::||.   .||:.||     .....|.|:|..|..:..|||.|.:||      
  Fly  1196 YRPPTKITVTTQMAAPQPMVKPDFYGV-----VNGEEILVILPQASEEYGPISHYYLVVVPEDKS 1255

Mouse   634 -----------EQLHPHRTKREAGAMECYQVPVTYQNALSGGAPYYFAAELPPGNLPEPAPFTVG 687
                       :.|.|.|.|.|                 ...|| |.||:.|..::  |..|.:|
  Fly  1256 NLHKIPDQFLTDDLLPGRNKPE-----------------RPNAP-YIAAKFPQRSI--PFTFHLG 1300

Mouse   688 DNRTYKGFWNPPLAPRKGYNIYFQAM----------SSVEKETKTQCVRIATKAAATE------- 735
            ....|..|.|..|...|.|.|:.:|:          ||...|..:..:|.|.......       
  Fly  1301 SGDDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWP 1365

Mouse   736 -EPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVIVIVKKRYICWRRHICIRNIRRSYYSYSY 799
             ||||..:..|....::.:. :...:..||:...::::.|.||    ||..|             
  Fly  1366 AEPEVSVNRNKDEPEILWVV-LPLMVSTFIVSTALIVLCVVKR----RRQPC------------- 1412

Mouse   800 YLKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRLPNDPLVPTA 864
                  |..|....||..|...:.|                           .| .|:||     
  Fly  1413 ------KTPDQAAVTRPLMAADLGA---------------------------GP-TPSDP----- 1438

Mouse   865 VLVPITDENHSATAESSRLLDVPRYLCEGTESPYQT-GQL-HPAIRVADLLQHINLMKTSDSYGF 927
                               :|:.|.       .:|| |.: ||.|.:::...||..:|::|:..|
  Fly  1439 -------------------VDMRRL-------NFQTPGMISHPPIPISEFANHIERLKSNDNQKF 1477

Mouse   928 KEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYR 992
            .:||||...||..:||.:..:.|::||||.|:.|||||||.|..||....||||||||.      
  Fly  1478 SQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYC------ 1536

Mouse   993 DGYQRPSHYIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFK 1056
            |||::.:.|:|||||:.||..|||||.|:.::|.|||:|.|.|..|:||.:|||. .||.||...
  Fly  1537 DGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIF 1601

Mouse  1057 VTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSA 1121
            ||..|.:.||.|.:|||.|.|:|:|:.||:||..||.|||||||.|....|.|:||.:...||.:
  Fly  1602 VTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPES 1666

Mouse  1122 GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE 1186
            ||::||||||.||||||||||.||:..:.|.::|||..|..||::|..|||||:|||||||||||
  Fly  1667 GPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE 1731

Mouse  1187 ACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNR 1251
            |.:||.|.:|..........::..:.....|.::.||:.|::|  ::.:.....|.||.|..|||
  Fly  1732 AIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNV--KMDSSKFVTANLPCNKHKNR 1794

Mouse  1252 FMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS 1315
            .:.:||.:....:|..|.| |.|:|:||:.:|.||..:|:|..|.|:.:..:||||:::::..|.
  Fly  1795 LVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTI 1859

Mouse  1316 IVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEG-YLMVQ 1377
            :|||.::..  .:.|.||||.|..:||....|:.::   :.::.....|...:|..::| ...|:
  Fly  1860 VVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIA---EYNMPQYKLREFKVTDARDGSSRTVR 1921

Mouse  1378 QFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMV 1442
            |||::.| ..:.||.|...|:..|.||.|.:|:..: :|...:||..|.||||:|..:.||:|.:
  Fly  1922 QFQFIDW-PEQGVPKSGEGFIDFIGQVHKTKEQFGQ-DGPITVHCSAGVGRSGVFITLSIVLERM 1984

Mouse  1443 KRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1484
            :.:.|:|||..|:.||:.:|.||:..:||.|||..|||||.|
  Fly  1985 QYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS 2026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtprkXP_006512669.1 MAM 31..191 CDD:214533 37/185 (20%)
IG 201..287 CDD:214652 18/106 (17%)
fn3 296..370 CDD:365830 30/126 (24%)
fn3 487..580 CDD:365830 29/193 (15%)
PTP_DSP_cys 911..1189 CDD:391942 149/278 (54%)
R-PTPc-K-2 1275..1480 CDD:350484 72/207 (35%)
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020 20/101 (20%)
FN3 520..610 CDD:238020 17/98 (17%)
FN3 616..707 CDD:238020 27/124 (22%)
FN3 712..810 CDD:238020 20/100 (20%)
FN3 832..907 CDD:238020 11/74 (15%)
FN3 914..1005 CDD:238020 15/90 (17%)
FN3 1012..1101 CDD:238020 14/89 (16%)
fn3 1106..1198 CDD:278470 12/93 (13%)
PTPc 1476..1731 CDD:214550 142/260 (55%)
PTPc 1503..1731 CDD:238006 132/233 (57%)
PTPc 1763..2022 CDD:214550 90/265 (34%)
PTPc 1791..2022 CDD:238006 82/235 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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