DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptprk and Ptp36E

DIOPT Version :9

Sequence 1:	XP_006512669.1	Gene:	Ptprk / 19272	MGIID:	103310	Length:	1485	Species:	Mus musculus
Sequence 2:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	679	Identity:	222/679 - (32%)
Similarity:	346/679 - (50%)	Gaps:	88/679 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse   833 STLHAEDPLSLTFMDQHN-FSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDVPRYLCEGTES 896
            |.|.:.:.:.|...|::| .|..:||.|                        :|:..:|
  Fly    55 SGLLSFERIKLEARDENNSLSKTIPNGP------------------------IDIRHFL------ 89

Mouse   897 PYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIA 961
                       ::.||.:...::       :|.|:::..:.:|.:...|.|..|..||:....|.
  Fly    90 -----------KLCDLRRKFPVL-------YKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIP 136

Mouse   962 YDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMVWQEQSAC 1026
            ||::||:|:.|.....|||:||:|:|..|      :|:.||.|||||.|||..:|||||||..:.
  Fly   137 YDYNRVVLEKVGGLQDSDYVNASYVDSLL------KPNAYIVTQGPVEETVQAYWRMVWQENISA 195

Mouse  1027 IVMVTNLVEVGRVKCYKYWPDDTEV---YGDFKVTCVEMEPLAEYVVRTFTL----ERRGYNEIR 1084
            |||:|...:..:|.|::|||.:.||   |||..:..|..|.||.:.:|||.|    |::...:.|
  Fly   196 IVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDER 260

Mouse  1085 EVKQFHFTGWPDHGVPYHATGLLSFIRRVKL-------SNPPSAGPIVVHCSAGAGRTGCYIVID 1142
            .:.|||:|.|..|..|: :..||.|.|||:|       ......|||:||||.|.||:|.|:.||
  Fly   261 LILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSID 324

Mouse  1143 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDM 1207
            ..|::||.|...:::..:|.||..|..:|:..|||.||:|.:.|..:||:|..||.|........
  Fly   325 ANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAK 389

Mouse  1208 IRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES 1272
            .|.:|.|..:..:.|:..:...|||....||:......|.:|||.:..:|||...|:|.:..|.:
  Fly   390 ARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNA 454

Mouse  1273 -SNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVML-NEVDLSQGCPQYWPEE 1335
             ::|||:..:|.|.:|..:|||::|:.:|:.:||.||||..|:::|:| .....||..|.:||.:
  Fly   455 FTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQYPSFWPNK 519

Mouse  1336 G-MLRYGPI-QVECMSCSMDCDV------INRIFRICNLTRPQEGY----LMVQQFQYLGWASHR 1388
            . |.:|||: .|..:......::      ||:  :|.:||....|.    ..||.||...|....
  Fly   520 SKMEKYGPVFSVHYVMSKSYTNIKQWEFKINK--KIVSLTEMMAGVKAPTRTVQLFQLTCWPMGH 582

Mouse  1389 EVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHA 1453
            :||.|..|.:.|:..||.|:.:.:.|.  ..:...:|..|:|::||....:|.|.:...||||.|
  Fly   583 KVPSSTNSLVYLMNMVEIWRNKVDYGP--VCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQA 645

Mouse  1454 VKTLRNSKPNMVEAPEQYRFCYDVALEYL 1482
            |||:|..:|.:||...:|::|||:.|.|:
  Fly   646 VKTVRRHRPQLVENMTEYKYCYDLVLHYV 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptprk	XP_006512669.1	MAM	31..191	CDD:214533
		IG	201..287	CDD:214652
		fn3	296..370	CDD:365830
		fn3	487..580	CDD:365830
		PTP_DSP_cys	911..1189	CDD:391942	111/291 (38%)
		R-PTPc-K-2	1275..1480	CDD:350484	73/217 (34%)
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	103/249 (41%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	83/246 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4141
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20096at33208
OrthoFinder	1	1.000	-	-		FOG0000829
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5477
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.760