DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptprc and Lar

DIOPT Version :9

Sequence 1:	NP_001104786.2	Gene:	Ptprc / 19264	MGIID:	97810	Length:	1293	Species:	Mus musculus
Sequence 2:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster

Alignment Length:	1384	Identity:	366/1384 - (26%)
Similarity:	559/1384 - (40%)	Gaps:	317/1384 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 FGFALLDT-EVFVTGQTPTPSDELSTTENALLLPQSD-PLPARTTESTPPSISERGNGSSETTYH 74
            |.|.::|| |..|||..|   |...:.:.|.|..:.| ...|.....||..:..|...|.:....
  Fly   766 FKFDVVDTLEFNVTGLQP---DTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMER 827

Mouse    75 PGVLSTLLPHLSPQPDSQTPSA--------GGADTQTFSSQADNPTLTPA-------------PG 118
            ..::|..|....|   :||...        |..|..........|.:|..             ..
  Fly   828 EPIVSIELEWERP---AQTYGELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRV 889

Mouse   119 GGTDPPGVPGERTV---------PGTIPADTAFPVDTPSL------------------------- 149
            .|::..|: |:.||         ||..|::......||.:
  Fly   890 AGSNHIGI-GQETVKIFQTPEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRNGIITRYDVQFH 953

Mouse   150 ---------ARNSSAASPTHTSNVSTTD--------ISSGA-----SLTTLTPSTLGLASTDPPS 192
                     .||.:......|:....|:        ...||     .|...|...:|.|   |.|
  Fly   954 KKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRA---PMS 1015

Mouse   193 TTIATTTKQTCAAMFGNIT---------VNYTYESSNQTFKADLKDVQNAKCGNEDCENVLNNLE 248
            .....|::||....:..:|         :.||     .|...||.|.|....|..:..::: |||
  Fly  1016 LQAEATSEQTAEIWWEPVTSRGKLLGYKIFYT-----MTAVEDLDDWQTKTVGLTESADLV-NLE 1074

Mouse   249 ECSQIKNISVSNDSCAPATTIDLYVPPGTDKFSLHDCTPKEKANTSICLEWKTKNLDFRKCNSDN 313
            :.:|.            |..|......|..:.|       ||....|..|....||  |..:...
  Fly  1075 KFAQY------------AVAIAARFKNGLGRLS-------EKVTVRIKPEDVPLNL--RAHDVST 1118

Mouse   314 ISYVLHCEPENNTKCIRRNTFIPERCQLDNLR--------AQTNYTCVAEILYRGVKLVKNVINV 370
            .|..|...|.      .|.|.:..:...|.::        :||......||      ::|:.:..
  Fly  1119 HSMTLSWSPP------IRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREI------ILKHYVKT 1171

Mouse   371 QT----------DLGIPETPKPSCGDPAARKTL---VSWPEPVSKPESASKPHGYVLCYKNNSEK 422
            .|          ::.:...|......|..:.|:   ::.|:|:.||:.    :|.|    |..|.
  Fly  1172 HTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDF----YGVV----NGEEI 1228

Mouse   423 CKSLPNNVTSFEVESLKPYKYYEVSLLAYVNGKIQRNGTAEKCNFHTKADR---PDKVNGM-KTS 483
            ...||.     ..|...|..:|.:.::           ..:|.|.|...|:   .|.:.|. |..
  Fly  1229 LVILPQ-----ASEEYGPISHYYLVVV-----------PEDKSNLHKIPDQFLTDDLLPGRNKPE 1277

Mouse   484 RPTDNSINVTCGPPY------ETNGPKTFYILVVRSGGSFVTKYNKTN------------CQFYV 530
            ||         ..||      :.:.|.||::      ||....:|.||            .:..|
  Fly  1278 RP---------NAPYIAAKFPQRSIPFTFHL------GSGDDYHNFTNRKLEREKRYRIFVRAVV 1327

Mouse   531 D----NLYYSTDY-EFLVSFHNGVYEGD---------------SVIRNESTNFNAKALIIFLVFL 575
            |    :||.|:.: |||.........|:               ||.||:.     :..|:::|..
  Fly  1328 DTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKD-----EPEILWVVLP 1387

Mouse   576 IIVTSIALLVVLYKIYDLRKKRSSNLDEQQELVERD----------------DEKQLMDVEP--- 621
            ::|::..:...|..:..::::|.......|..|.|.                |.::|....|
  Fly  1388 LMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMI 1452

Mouse   622 IHSDILLETYKRKI----ADEGRLFLAEFQSIPRVFSKFPIKDARKPHNQNKNRYVDILPYDYNR 682
            .|..|.:..:...|    :::.:.|..|::|| ....:|...::...||::||||.::..||::|
  Fly  1453 SHPPIPISEFANHIERLKSNDNQKFSQEYESI-EPGQQFTWDNSNLEHNKSKNRYANVTAYDHSR 1516

Mouse   683 VELSEINGDAGSTYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGN 747
            |:|..:.|..||.||||:|.||:::...|:|.|||..||..|||||.||.|...|||:||.||..
  Fly  1517 VQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERT 1581

Mouse   748 RNKCAEYWPSMEEGTRAFKDIVVTINDHKRCPDYIIQKLNVAHKKEKATG----REVTHIQFTSW 808
            |.||.:|||:  .||..:..|.|||.:.:....|.|:...:..:     |    ||:..:|||:|
  Fly  1582 RIKCDQYWPT--RGTETYGQIFVTITETQELATYSIRTFQLCRQ-----GFNDRREIKQLQFTAW 1639

Mouse   809 PDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAEGKVDVYGY 873
            ||||||:.|...|:..||..|.:...|||::|||||||||||.||.||:|||.::.|..:|:||:
  Fly  1640 PDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGH 1704

Mouse   874 VVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHSCLHNMKKRDPPSDPSPLEAEYQ 938
            |..||.||..|||.|.|||.||.|::|....|.|||....||:.|..:...:|....|.:|.|::
  Fly  1705 VTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFK 1769

Mouse   939 RLPSYRSWRTQHI-GNQEENKKKNRNSNVVPYDFNRVPLK--HELEMSKESEPESDESSDDDSDS 1000
            :|.:.:...::.: .|...||.|||..:::||:.:||.|.  |.:
  Fly  1770 KLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGI-------------------- 1814

Mouse  1001 EETSKYINASFVMSYWKPEMMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELVNGDQEVCAQYW 1065
             |.|.|:||||:..|......||||||:::...|||:|:::....::||||:|....:|.|.|||
  Fly  1815 -EGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYW 1878

Mouse  1066 -GEGKQTYGDMEVEMKDTNRASAYTLRTFELRHSKRKEPRTVYQYQCTTWKGEELPAEPK---DL 1126
             .|....|....|:.........|.||.|::..::....|||.|:|...|..:.:|...:   |.
  Fly  1879 PHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDF 1943

Mouse  1127 VSMIQDLKQKLPKASPEGMKYHKHASILVHCRDGSQQTGLFCALFNLLESAETEDVVDVFQVVKS 1191
            :..:...|::..:..|          |.|||..|..::|:|..|..:||..:.|.|:||||.|:.
  Fly  1944 IGQVHKTKEQFGQDGP----------ITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRI 1998

Mouse  1192 LRKARPGVVCSYEQYQFLY 1210
            ||..||.:|.:.:||.|.|
  Fly  1999 LRSQRPAMVQTEDQYHFCY 2017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptprc	NP_001104786.2	PTP_N	7..31	CDD:372119	9/19 (47%)
		Herpes_BLLF1	<27..>191	CDD:282904	39/241 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..174		31/208 (15%)
		CD45	212..265	CDD:372194	12/52 (23%)
		FN3	393..451	CDD:238020	13/60 (22%)
		FN3	474..553	CDD:238020	23/102 (23%)
		R-PTPc-C-1	696..896	CDD:350405	99/203 (49%)
		Substrate binding. /evidence=ECO:0000250	842..848		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	980..1003		0/22 (0%)
		R-PTP-C-2	1006..1211	CDD:350406	69/209 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1240..1293
Lar	NP_001260594.1	Ig	35..129	CDD:299845
		I-set	36..129	CDD:254352
		IG_like	146..227	CDD:214653
		Ig	159..228	CDD:299845
		I-set	234..318	CDD:254352
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216
		fn3	324..404	CDD:278470
		FN3	423..514	CDD:238020
		FN3	520..610	CDD:238020
		FN3	616..707	CDD:238020
		FN3	712..810	CDD:238020	14/46 (30%)
		FN3	832..907	CDD:238020	14/78 (18%)
		FN3	914..1005	CDD:238020	10/90 (11%)
		FN3	1012..1101	CDD:238020	25/116 (22%)
		fn3	1106..1198	CDD:278470	16/105 (15%)
		PTPc	1476..1731	CDD:214550	120/262 (46%)
		PTPc	1503..1731	CDD:238006	113/234 (48%)
		PTPc	1763..2022	CDD:214550	86/286 (30%)
		PTPc	1791..2022	CDD:238006	80/258 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810