Protein Alignment Ptpra and Ptp36E

DIOPT Version :10

• Sequence 1: XP_036015592.1
• Gene: Ptpra / 19262
• MGIID: 97808
• Length: 838
• Species: Mus musculus
• Sequence 2: NP_609872.1
• Gene: Ptp36E / 35091
• FlyBaseID: FBgn0267486
• Length: 682
• Species: Drosophila melanogaster
• Alignment Length: 682
• Identity: 194/682 - (28%)
• Similarity: 341/682 - (50%)
• Gaps: 94/682 - (13%)

Mouse   218 QAGSHSNSFRLSNGRTEDVEPQ--------SVP-------------------LLAR--SPSTNRK 253
            :.|.|.:.   |:.|.:|||.|        |:|                   |.||  :.|.::.
  Fly    16 KTGKHRSR---SSARYDDVEKQQRKSRAIVSIPNTIKLSMLNSGLLSFERIKLEARDENNSLSKT 77

Mouse   254 YPPLPVD-----KLEEEINRRMADDNKLFREEFNALPACPIQA-TCEAASKEENKEKNRYVNILP 312
            .|..|:|     || .::.|:..   .|::.||..  |..::: ||..|.|:.|.|||:....:|
  Fly    78 IPNGPIDIRHFLKL-CDLRRKFP---VLYKLEFQT--AAKVESNTCRHALKKNNLEKNQNPKCIP 136

Mouse   313 YDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTN 377
            ||::||.|..|.|:.||||:|||:::...:.|.:|..|||.||||..:|||:|::|.:.|||:|.
  Fly   137 YDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTK 201

Mouse   378 LKERKECKCAQYWP------DQGCWTYGNVRVSVEDVTVLVDYTVRKFCIQQVGDVTNRKPQRLI 436
            ..:..:..|.||||      :|    ||::.:::.....|.::.:|.|.:.::.:......:|||
  Fly   202 TFDFAKVMCHQYWPPNMEVHEQ----YGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLI 262

Mouse   437 TQFHFTSWPDFGVPFTPIGMLKFLKKVKAC-------NPQYAGAIVVHCSAGVGRTGTFVVIDAM 494
            .|||:|.|.....||:. .:|:|.::|:..       .....|.|:||||.|.||:|.::.|||.
  Fly   263 LQFHYTEWYSHSCPFSN-ALLEFRRRVRLVVGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDAN 326

Mouse   495 LDMMHSERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYN 559
            |::...|...:|:|::.::|..|..:|:...||.|||..|.||.:.|.|...|:.|...|:....
  Fly   327 LELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKAR 391

Mouse   560 KIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPA-----NMKKNRVLQIIPYEFNRVIIPVKRGE 619
            :..||..|..:.|:.::..   |..:...|:...     |.:|||.:..:|.:..|..:...:|.
  Fly   392 RNSGTKMNEYQAEYDQICK---QTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGN 453

Mouse   620 ENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP 684
            ..|||:|:.|:|||.:...||.::.|:.||:.:||.::::.:..::|:|.:...:.|: ...:||
  Fly   454 AFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQ-YPSFWP 517

Mouse   685 SDG-LVSYGDI----------TVELKKEEECESYTVRDLLVTNTR-----ENKSRQIRQFHFHGW 733
            :.. :..||.:          ...:|:.|    :.:...:|:.|.     :..:|.::.|....|
  Fly   518 NKSKMEKYGPVFSVHYVMSKSYTNIKQWE----FKINKKIVSLTEMMAGVKAPTRTVQLFQLTCW 578

Mouse   734 PEVG--IPSDGKGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDV 796
            | :|  :||....::.::..|:..:.:....|:.|....|..|.|.:||.:..:|:|...|.:||
  Fly   579 P-MGHKVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDV 642

Mouse   797 FQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI 828
            ||.||::|..||.:|:.:.:|::||.:|..|:
  Fly   643 FQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpra	XP_036015592.1	R-PTPc-A-1	250..545	CDD:350469	105/313 (34%)
		R-PTPc-A-2	599..826	CDD:350471	62/244 (25%)
Ptp36E	NP_609872.1	Y_phosphatase	125..368	CDD:459674	87/247 (35%)
		Y_phosphatase	428..671	CDD:459674	64/248 (26%)