DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirpa and nrm

DIOPT Version :9

Sequence 1:	NP_001277948.1	Gene:	Sirpa / 19261	MGIID:	108563	Length:	513	Species:	Mus musculus
Sequence 2:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	122/553 - (22%)
Similarity:	187/553 - (33%)	Gaps:	176/553 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    33 ELKVTQPEKSVSV--AAGD---------------STVLNCTLTSLLPVGPIRWYRGVGPSRLLIY 80
            ||:|..|...|.:  |.||               |....||:.:..|...:.|:||.  .||..|
  Fly   148 ELRVLVPPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFRGT--KRLTTY 210

Mouse    81 S-----FAGEYVPRIRNVSDTTKRNNM--DFSIR-----ISNVTPADAGIYYCVKFQKGSSEPDT 133
            |     ..|.|...: .:..|..|.::  |...|     |.|||        ..||
  Fly   211 SPTHDLVDGLYTSTL-ELDWTLSREDLAQDIECRVKSAAIQNVT--------VTKF--------- 257

Mouse   134 EIQSGGGTEVYVLAKPSPPEVSGPADRGIPDQKVNFTCKSHGFSPRNITLKWFKDGQELHPLETT 198
                    .|.:..:|:..:::|.....:...||..||..||..|. :.|.|:.        .||
  Fly   258 --------SVDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPA-VNLTWYN--------TTT 305

Mouse   199 VNPSGKNVSYNISS------------TVRVVLNSMDV-NSKVI-CEVAHITLD---RSPLRGIAN 246
            :..||:|....:.|            ...::.|:... |.:|. ||..:|.|.   ..|:.....
  Fly   306 IISSGENEITEVRSKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALT 370

Mouse   247 LSNFIRVSPTVKVTQQSPTSMNQVNLTCRAERF-YPEDL-QLIWLENG-NVSRNDTPKNLTKNTD 308
            |.  :...|.|||:..:.|:.....:....|.| .|..| |:.|..|. .|:.|||    |....
  Fly   371 LE--VLYPPVVKVSPSAITANTSEIVLLNCEYFANPASLTQVEWYRNDILVNVNDT----THYKG 429

Mouse   309 GTYNYTSLFLVNSSAHREDV-VFTCQVKHDQQPAITRNHTVLGFAHSSDQGSMQTFPDNNATHNW 372
            |  |..::.||..|..:||: .::||:.::           :| ..:|||.
  Fly   430 G--NSENVALVIKSTEKEDIGNYSCQLSNN-----------IG-KGTSDQK-------------- 466

Mouse   373 NVFIGVGVACALLVVLLMAALYLLRIKQKKAKGSTSST---RLHEPEKNAREITQVQSLIQDTND 434
               |.:.|..|..|.:||       |.:...|.|..|.   ..:..:.|...:|:|:
  Fly   467 ---INLDVQYAPTVEILM-------IPEGPVKESDESNVTLFCNVLDANPSVLTKVR-------- 513

Mouse   435 INDITYADLNLPKEKKPAPRAPEPNNHTEYASI-------------------ETGKVPRPEDTLT 480
                .||:..|.||........|...|.:.:.:                   ..|..||.||
  Fly   514 ----WYANSTLLKELPDCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAGWGPRSED--- 571

Mouse   481 YADLDMVHLSRAQPAPKPEPSFSEYASVQVQRK 513
             .:| :||.   :|.|   .:.|.:..|.|::|
  Fly   572 -KEL-LVHY---EPGP---AALSHFPLVAVKKK 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirpa	NP_001277948.1	Ig	35..146	CDD:416386	30/139 (22%)
		FR1	35..56	CDD:409353	7/37 (19%)
		Ig strand A	35..38	CDD:409353	1/2 (50%)
		Ig strand A'	42..46	CDD:409353	1/5 (20%)
		Ig strand B	49..57	CDD:409353	3/22 (14%)
		CDR1	57..63	CDD:409353	0/5 (0%)
		FR2	64..72	CDD:409353	2/7 (29%)
		Ig strand C	64..70	CDD:409353	1/5 (20%)
		CDR2	73..87	CDD:409353	5/18 (28%)
		Ig strand C'	76..79	CDD:409353	2/2 (100%)
		Ig strand C'	85..88	CDD:409353	1/2 (50%)
		FR3	88..126	CDD:409353	10/44 (23%)
		Ig strand D	89..93	CDD:409353	0/3 (0%)
		Ig strand E	103..109	CDD:409353	2/10 (20%)
		Ig strand F	117..124	CDD:409353	0/6 (0%)
		CDR3	127..132	CDD:409353	0/4 (0%)
		Ig strand G	132..137	CDD:409353	0/4 (0%)
		FR4	133..146	CDD:409353	1/12 (8%)
		Ig strand G'	140..145	CDD:409353	1/4 (25%)
		IgC1_SIRP_domain_2	148..250	CDD:409429	26/118 (22%)
		Ig strand B	167..171	CDD:409429	1/3 (33%)
		Ig strand C	182..186	CDD:409429	1/3 (33%)
		Ig strand E	212..216	CDD:409429	1/15 (7%)
		Ig strand F	226..231	CDD:409429	2/5 (40%)
		Ig strand G	242..245	CDD:409429	0/2 (0%)
		IgC1_SIRP_domain_3	253..348	CDD:409507	26/98 (27%)
		Ig strand B	270..274	CDD:409507	0/3 (0%)
		Ig strand C	285..289	CDD:409507	1/3 (33%)
		Ig strand E	315..319	CDD:409507	0/3 (0%)
		Ig strand F	329..334	CDD:409507	1/4 (25%)
		Ig strand G	343..346	CDD:409507	0/2 (0%)
		SH2-binding. /evidence=ECO:0000255	440..443		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..513		18/87 (21%)
		SH3-binding. /evidence=ECO:0000255	450..455		0/4 (0%)
		SH2-binding. /evidence=ECO:0000255	464..467		0/2 (0%)
		SH2-binding. /evidence=ECO:0000255	481..484		0/2 (0%)
		SH2-binding. /evidence=ECO:0000255	505..508		0/2 (0%)
nrm	NP_001246890.1	Ig	44..152	CDD:299845	2/3 (67%)
		Ig	176..248	CDD:299845	17/74 (23%)
		Ig	277..354	CDD:299845	20/85 (24%)
		IG_like	383..463	CDD:214653	23/97 (24%)
		Ig	394..463	CDD:143165	22/86 (26%)
		Ig_3	585..652	CDD:290638	4/12 (33%)
		Ig	685..>719	CDD:299845
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000