Protein Alignment Ptpn22 and PTP-ER

DIOPT Version :9

• Sequence 1: NP_033005.1
• Gene: Ptpn22 / 19260
• MGIID: 107170
• Length: 802
• Species: Mus musculus
• Sequence 2: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Alignment Length: 515
• Identity: 111/515 - (21%)
• Similarity: 158/515 - (30%)
• Gaps: 255/515 - (49%)

Mouse     2 DQREILQQLLKEAQKKKLNSEE----FASEFLKLKRQSTKYKADKIYPTTVAQRPKNIKKNRYKD 62
            :|:.|.:.|.||.....||.:|    |.|:                            .|||||.
  Fly   887 EQKRIFRDLHKEFWDLPLNHQEKPMVFGSQ----------------------------TKNRYKT 923

Mouse    63 ILPYDHSLVEL-----------------SLLTSDEDSSYINASFIKGV-YGPKAYIATQGPLSTT 109
            |||.::|.|.|                 |.:|:.||..||||::|||. |..|.|:||||||..|
  Fly   924 ILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNT 988

Mouse   110 LLDFWRMIWE----------------------YRIL-----VIVMACMEFEMGKKKCERYWAEPG 147
            :.:||.||::                      .:||     .|||.....|..::||..|:  |.
  Fly   989 IFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYF--PI 1051

Mouse   148 ETQLQFG------PFSISCEAEK------------------------------------------ 164
            |....|.      .|.:|..|..
  Fly  1052 ELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEG 1116

Mouse   165 ---------------------KKSDYKIRTL----------KAKFNNETRIIYQFHYKNWPDHDV 198
                                 :::.|.:|.|          .|.::.:....|.:.|.:||||..
  Fly  1117 DLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHS 1181

Mouse   199 PSSIDPILQL---------------IWD--------------MRCYQED-----DCVPICIHCSA 229
            |..|:.:|..               |:|              :..||:|     ..:|: |||||
  Fly  1182 PRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPV-IHCSA 1245

Mouse   230 GCGRTGVICAV-------------DYTWMLLKD-------------------------------- 249
            |.||||...|:             ..|.||.|.
  Fly  1246 GIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILD 1310

Mouse   250 -------------GIIPKNFSVF----NLIQEMRTQRPSLVQTQEQYELVYSAVLELFKR 292
                         ..:||...:|    .::..:|.||..:||..|||||::.|:....||
  Fly  1311 HRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLYLKR 1370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpn22	NP_033005.1	PTPc-N22	57..290	CDD:350450	99/452 (22%)
		Substrate binding. /evidence=ECO:0000250	227..233		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..358
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..564
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..619
		Interaction with CSK. /evidence=ECO:0000269|PubMed:8890164	613..621
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..695
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	713..802
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	98/478 (21%)
		PTPc	917..1364	CDD:238006	98/449 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900