DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpn4 and Ptpmeg

DIOPT Version :9

Sequence 1:	NP_064317.2	Gene:	Ptpn4 / 19258	MGIID:	1099792	Length:	926	Species:	Mus musculus
Sequence 2:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster

Alignment Length:	1009	Identity:	418/1009 - (41%)
Similarity:	576/1009 - (57%)	Gaps:	147/1009 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MTARFRL-PAGRTYNVRAS--ELARDR---QHTEVVCNILLLDNTVQAFRVNKHDQGQVLLDIVF 59
            |..|||| ...||:.:|..  |||||:   |..:.| .:|.||:....||:.|..:|..|||.||
  Fly     1 MFERFRLNNLTRTFRLRGGGPELARDKKTPQRQQCV-TVLFLDDITHTFRIEKRAKGSELLDQVF 64

Mouse    60 KHLDLTERDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYN-----LNFRVKFFVSDPNKLQE 119
            ::|:|:|||||||.......|..||:|..|..:||....|..|     |.||||||||||::|||
  Fly    65 QYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQE 129

Mouse   120 EYTRYQYFLQIKQDILTGRLSCPCNTAALLASFAVQSELGDYNQSENLAGYLSDYSFIPNQPQDF 184
            |:||||::||||::||.|:|.|..||..||||:.|||||||:|..|:..||||....:.:|..:.
  Fly   130 EFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEA 194

Mouse   185 EKEIAKLHQQHVGLSPAEAEFNYLNAARTLELYGVEFHYARDQSNNEILIGVMSGGILIYKNRVR 249
            |:::.:||:.|.|..||:||:|||..|:.|||||::.|.|.|.:..|:.:||.:.|:|::::.:|
  Fly   195 ERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLR 259

Mouse   250 MNTFLWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKTLWKACVEHHTFFRLDRPL 314
            :|||.|.|:||:|||.|.||||||:|..|:.:|||||.|.:::..|.|||:|||||:||||.|
  Fly   260 VNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR-- 322

Mouse   315 PPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSLS 379
            |.:.:.|.: .:|||||.|.||||:|:||..|::....:||.|||||.|        :.:...:.
  Fly   323 PHRLSRFLN-ISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRL--------LGAAGGVG 378

Mouse   380 DDRLETQSLPSRSPPGTP--NHRNSSFTQEATRVRPSSVGHLVDHVVHMSPSEDFVSQRSPSSTQ 442
                     .|.|..|||  .|..|.........:|:..|.::.......|.::.|     :|.:
  Fly   379 ---------TSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKV-----TSKE 429

Mouse   443 ANSIVLESSPSQETP-----------------EDGQPPALPPKQSKKNSWNQIHFSNSQQDLVTH 490
            |:|:..::...|...                 |...|..:||..| ....:.|....:..|.|.|
  Fly   430 ADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYS-SGQHSPILLPTTIADAVGH 493

Mouse   491 TNESFDVPSSPEKSTPNGGIPHDNLVLIKMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADL 555
                    ..||..:        :|:.|:::.||.||:|||||||.|..:||.||:|.|.||||.
  Fly   494 --------QQPESGS--------DLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADR 542

Mouse   556 CVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCEKHSGELVLLVRPNAVYDVVEEKLESEPDF 620
            |.||:.|||:|::|||||:....|:|||..|:....:.||||:|.|||.....::   ||.||.:
  Fly   543 CTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLL---LEEEPLY 604

Mouse   621 QYIPEKAPLDSVHQD----DHSLRESMIQLAEGLITGTVLAQFDQLYRKKPGMTMSCAKLPQNIS 681
            ||:||...:.| |.:    |....:|::.|::||.:|.:|||::.:|||.|.:.::.|:.|.|..
  Fly   605 QYVPESDEIGS-HSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAP 668

Mouse   682 KNRYRDISPYDATRVLLKGN--EDYINANYINMEIPSSSIINQYIACQGPLPHTCKDFWQMTWEQ 744
            |||||||||||.|||.|..:  .|||||||:|||||..: :|:|||.||||..|..|||:|..::
  Fly   669 KNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGA-VNRYIATQGPLASTTTDFWRMVQQE 732

Mouse   745 GSSMVVMLTTQVERGRVKCHQYWPEPSESSSYG-CYQVTCHSEEGNP--AYIFRKMTLFNQEKNE 806
            .|.::|||||.:|.||.|||||||...|..... .:.|.|.||:.:.  :::||:..|  ::|:|
  Fly   733 SSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVL--KDKHE 795

Mouse   807 SRQLTQIQYTAWPDHGVPDDSSDFLDFVCHVR---------------------------DQRAG- 843
            .|.:..:||.|||||.||.|.:.||:|...||                           |:..|
  Fly   796 QRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGL 860

Mouse   844 --------------KEE----------------PIIVHCSAGIGRTGVLITMETAMCLIECNQPV 878
                          ::|                |:|||||||||||||||.|:||:.|:|..:||
  Fly   861 MRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPV 925

Mouse   879 YPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY 912
            ||||||||||||||.|:|..||||||||.|...|
  Fly   926 YPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpn4	NP_064317.2	B41	30..222	CDD:214604	97/196 (49%)
		FERM_N	33..97	CDD:286467	28/63 (44%)
		FERM_M	115..222	CDD:278785	55/106 (52%)
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010	48/93 (52%)
		FA	325..365	CDD:285894	22/39 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..412		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..474		10/61 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..511		2/18 (11%)
		PDZ_signaling	515..602	CDD:238492	46/86 (53%)
		PTPc	657..910	CDD:214550	142/315 (45%)
		PTPc	682..909	CDD:238006	132/289 (46%)
		Substrate binding. /evidence=ECO:0000250	852..858		5/5 (100%)
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	97/197 (49%)
		FERM_N	38..102	CDD:286467	28/63 (44%)
		FERM_M	125..232	CDD:278785	55/106 (52%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	48/93 (52%)
		FA	333..369	CDD:285894	20/35 (57%)
		PDZ_signaling	502..589	CDD:238492	46/86 (53%)
		Y_phosphatase	666..955	CDD:278528	133/291 (46%)
		PTPc	668..955	CDD:238006	132/289 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I3181
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2120
Inparanoid	1	1.050	644	1.000	Inparanoid score	I801
Isobase	1	0.950	-	0	Normalized mean entropy	S3284
OMA	1	1.010	-	-		QHG49050
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006212
OrthoInspector	1	1.000	-	-		otm44231
orthoMCL	1	0.900	-	-		OOG6_104957
Panther	1	1.100	-	-	O	PTHR45706
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5775
SonicParanoid	1	1.000	-	-		X1974
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810