DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpn18 and CG42327

DIOPT Version :9

Sequence 1:	NP_035336.2	Gene:	Ptpn18 / 19253	MGIID:	108410	Length:	453	Species:	Mus musculus
Sequence 2:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	105/353 - (29%)
Similarity:	155/353 - (43%)	Gaps:	73/353 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 RHTDLVRSFLEQLEARDYREGAILAREFSDIKARSVAWKSEGVCSTKAGSRLGNTNKNRYKDVVA 67
            ||..|..|.|    ||.....:.:..||.|:.  .:..:::.|..       |..:||||.:|:.
  Fly  1092 RHNLLTASEL----ARFVERRSDVFEEFRDVP--QIIARADEVPP-------GCEDKNRYANVIP 1143

Mouse    68 YDETRVILSLLQEEGHGDYINANFIRG-IDGSQAYIATQGPLPHTLLDFWRLVWEFGVKVILMAC 131
            ..||||:|....::...:|||||::|| .|....|||.|.||..|..||||::||...:||:.|.
  Fly  1144 LPETRVVLQRQGDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQAT 1208

Mouse   132 QETENGRRKCERYW---AREQEPLKAGPFCITLT-KETTLNADITLRTLQVTFQKEFRSVHQLQY 192
            ..:|||..:|..|.   |........|.:.:||. :|......|:...|:....:|.|.:....|
  Fly  1209 DLSENGIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKRVDGEESRELTHYWY 1273

Mouse   193 MSWPDHGVPSSSDHILTMVEEARC----------------------------------------L 217
             .||:.|||:....|:.|:.|||.                                        :
  Fly  1274 -KWPEAGVPAEEAPIIAMLLEARSSLKSYSLEQANELREKSATLETSMDADGSKAEAGSTSSHEI 1337

Mouse   218 QG---------LGPGPLCVHCSAGCGRTGVLCAVDY-VRQLLLTQTIPPNFSLFQVVLEMRKQRP 272
            .|         ...|||.||||.|.||||.:.|.|. :|.|   :|...:..:.|:|..:|:.|.
  Fly  1338 NGNISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSL---ETPKRSVDIPQLVYYVRRGRA 1399

Mouse   273 AAVQTEEQYRFLYHTVAQLFSRTLQDTS 300
            :||||:|||.|:| .||.:::..:.:.|
  Fly  1400 SAVQTKEQYEFIY-KVASMYAAKITNLS 1426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpn18	NP_035336.2	Y_phosphatase	56..290	CDD:278528	91/288 (32%)
		PTPc	59..290	CDD:238006	91/285 (32%)
		Substrate binding. /evidence=ECO:0000250	229..235		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..453
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	90/285 (32%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	90/285 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900