DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31381 and MOD5

DIOPT Version :9

Sequence 1:	NP_001189283.1	Gene:	CG31381 / 192528	FlyBaseID:	FBgn0043799	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_014917.3	Gene:	MOD5 / 854448	SGDID:	S000005800	Length:	428	Species:	Saccharomyces cerevisiae

Alignment Length:	481	Identity:	147/481 - (30%)
Similarity:	235/481 - (48%)	Gaps:	91/481 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIRKVPLIVVLGSTGTGKTKLSLQLAERFGGEIISADSMQVYTHLDIATAKATKEEQSRARHHLL 65
            |.:||  ||:.|:||.||::||:|||::|.||:|::||||||..:.|.|.|...:|:....||::
Yeast    12 MSKKV--IVIAGTTGVGKSQLSIQLAQKFNGEVINSDSMQVYKDIPIITNKHPLQEREGIPHHVM 74

  Fly    66 DVATPAEPFTVTHFRNAALPIVERLLAKDTSPIVVGGTNYYIESLLWDILVDSDVKPDEGKHSGE 130
            :....:|.:....|....:..:|.:..:...|||||||:||::: |::..||:       |.|..
Yeast    75 NHVDWSEEYYSHRFETECMNAIEDIHRRGKIPIVVGGTHYYLQT-LFNKRVDT-------KSSER 131

  Fly   131 HLKDAELNALSTLE---LHQHLAKIDAGSANRIHPNNRRKIIRAIEVYQSTGQTLSQMLAEQRAQ 192
            .|...:|:.|.:.:   ::..|.|.|...|.:.|||:.|::.|.:|:|..||:..|:...||:.
Yeast   132 KLTRKQLDILESTDPDVIYNTLVKCDPDIATKYHPNDYRRVQRMLEIYYKTGKKPSETFNEQKI- 195

  Fly   193 PGGNRLGGPLRYPHIVLLWLRCQQDVLNERLDSRVDGMLAQGLLPELRQFHN--AHHATTVQAYT 255
                    .|:: ..:.|||..:.:.|.:|||.|||.||.:|.|.|::|.:.  :.:..|.:...
Yeast   196 --------TLKF-DTLFLWLYSKPEPLFQRLDDRVDDMLERGALQEIKQLYEYYSQNKFTPEQCE 251

  Fly   256 SGVLQTIGYKEFIPYLIKYDQQQDEKIEEYLKTHSYKLPGPEKLKEEGLPDGLELLRNCCEELKL 320
            :||.|.||:|||:|:|.........|:|:                             |.|.:|.
Yeast   252 NGVWQVIGFKEFLPWLTGKTDDNTVKLED-----------------------------CIERMKT 287

  Fly   321 VTRRYSKKQLKWINNRFLASKDRQVP----DLYELDTSDVSAWQVAVYKRAETI---------IE 372
            .||:|:|:|:|||       |...:|    |:|.||.:|:|.|.....:||..|         |:
Yeast   288 RTRQYAKRQVKWI-------KKMLIPDIKGDIYLLDATDLSQWDTNASQRAIAISNDFISNRPIK 345

  Fly   373 SYRNEEACEILPMAKREHPGADLDEETSHFCQICERH------FVGEYQWGLHMKSNKHKRRKEG 431
            ..|..:|.|.| ::|.|.....||:.|.:.|.:|...      .:||..|.:|:.|.:||...:
Yeast   346 QERAPKALEEL-LSKGETTMKKLDDWTHYTCNVCRNADGKNVVAIGEKYWKIHLGSRRHKSNLK- 408

  Fly   432 QRKRQRDHETMLSTDLAKKQKEEKEE 457
            :..||.|.|         |.|..|:|
Yeast   409 RNTRQADFE---------KWKINKKE 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31381	NP_001189283.1	PLN02748	1..446	CDD:215399	143/468 (31%)
		miaA	4..337	CDD:234626	107/337 (32%)
		zf-C2H2_jaz	401..426	CDD:288983	7/30 (23%)
MOD5	NP_014917.3	miaA	16..320	CDD:213512	112/359 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346716
Domainoid	1	1.000	122	1.000	Domainoid score	I1246
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7010
Inparanoid	1	1.050	197	1.000	Inparanoid score	I876
Isobase	1	0.950	-	0	Normalized mean entropy	S1796
OMA	1	1.010	-	-		QHG54912
OrthoFinder	1	1.000	-	-		FOG0003361
OrthoInspector	1	1.000	-	-		oto99201
orthoMCL	1	0.900	-	-		OOG6_100923
Panther	1	1.100	-	-	LDO	PTHR11088
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R730
SonicParanoid	1	1.000	-	-		X1130
TreeFam	0	0.000	Not matched by this tool.
	14	13.880